Alessandro P Delitala1,2, Angelo Scuteri1, Edoardo Fiorillo2, Valeria Orrù2, Edward G Lakatta3, David Schlessinger4, Francesco Cucca2,5. 1. Department of Medical, Surgical, and Experimental Sciences, University of Sassari, 07100 Sassari, Italy. 2. Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, 09042 Cagliari, Italy. 3. Laboratory of Cardiovascular Sciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. 4. National Institute on Aging, NIH, DHHS, Baltimore, MD 21224, USA. 5. Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Abstract
BACKGROUND: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. METHODS: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wall-lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. RESULTS: FT4 was positively and independently associated with β stiffness index (β = 0.026, p = 0.041), and had a negative association with strain (β = -0.025, p = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, p = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, p < 0.001) as well as their interaction (β = 0.271, p = 0.007). CONCLUSION: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate.
BACKGROUND: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. β-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. METHODS: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed β stiffness, strain, wall-lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. RESULTS:FT4 was positively and independently associated with β stiffness index (β = 0.026, p = 0.041), and had a negative association with strain (β = -0.025, p = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the β stiffness index (β = 0.186, p = 0.06), heart rate was positively associated with the stiffness index (β = 0.389, p < 0.001) as well as their interaction (β = 0.271, p = 0.007). CONCLUSION: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate.
Authors: Thomas T van Sloten; Sanaz Sedaghat; Stéphane Laurent; Gérard M London; Bruno Pannier; M Arfan Ikram; Maryam Kavousi; Francesco Mattace-Raso; Oscar H Franco; Pierre Boutouyrie; Coen D A Stehouwer Journal: J Am Coll Cardiol Date: 2015-11-10 Impact factor: 24.094
Authors: Eric Y Yang; Lloyd Chambless; A Richey Sharrett; Salim S Virani; Xiaoxi Liu; Zhengzheng Tang; Eric Boerwinkle; Christie M Ballantyne; Vijay Nambi Journal: Stroke Date: 2011-10-27 Impact factor: 7.914
Authors: Kennedy Cruickshank; Lisa Riste; Simon G Anderson; John S Wright; Graham Dunn; Ray G Gosling Journal: Circulation Date: 2002-10-15 Impact factor: 29.690
Authors: Wismandari Wisnu; Idrus Alwi; Nafrialdi Nafrialdi; Kuntjoro Harimurti; Tjokorda Gede D Pemayun; Sri Widia A Jusman; Dewi Irawati S Santoso; Alida R Harahap; Suhendro Suwarto; Imam Subekti Journal: Front Endocrinol (Lausanne) Date: 2021-12-20 Impact factor: 5.555