| Literature DB >> 24952961 |
Carol L Thompson1, Lydia Ng1, Vilas Menon1, Salvador Martinez2, Chang-Kyu Lee1, Katie Glattfelder1, Susan M Sunkin1, Alex Henry1, Christopher Lau1, Chinh Dang1, Raquel Garcia-Lopez3, Almudena Martinez-Ferre3, Ana Pombero3, John L R Rubenstein4, Wayne B Wakeman1, John Hohmann1, Nick Dee1, Andrew J Sodt1, Rob Young1, Kimberly Smith1, Thuc-Nghi Nguyen1, Jolene Kidney1, Leonard Kuan1, Andreas Jeromin1, Ajamete Kaykas1, Jeremy Miller1, Damon Page1, Geri Orta1, Amy Bernard1, Zackery Riley1, Simon Smith1, Paul Wohnoutka1, Michael J Hawrylycz5, Luis Puelles6, Allan R Jones1.
Abstract
To provide a temporal framework for the genoarchitecture of brain development, we generated in situ hybridization data for embryonic and postnatal mouse brain at seven developmental stages for ∼2,100 genes, which were processed with an automated informatics pipeline and manually annotated. This resource comprises 434,946 images, seven reference atlases, an ontogenetic ontology, and tools to explore coexpression of genes across neurodevelopment. Gene sets coinciding with developmental phenomena were identified. A temporal shift in the principles governing the molecular organization of the brain was detected, with transient neuromeric, plate-based organization of the brain present at E11.5 and E13.5. Finally, these data provided a transcription factor code that discriminates brain structures and identifies the developmental age of a tissue, providing a foundation for eventual genetic manipulation or tracking of specific brain structures over development. The resource is available as the Allen Developing Mouse Brain Atlas (http://developingmouse.brain-map.org).Entities:
Mesh：
Year: 2014 PMID： 24952961 PMCID： PMC4319559 DOI： 10.1016/j.neuron.2014.05.033
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173