| Literature DB >> 15036211 |
Jun Hatakeyama1, Ryoichiro Kageyama.
Abstract
Retinal development is controlled antagonistically by multiple basic helix-loop-helix (bHLH) transcriptional activators and repressors. bHLH repressors suppress bHLH activators and promote maintenance of progenitors and generation of glial cells. In contrast, bHLH activators override activities of bHLH repressors and promote neuronal differentiation. However, bHLH activators alone are not sufficient but homeodomain factors are additionally required for neuronal subtype specification. It is likely that homeodomain factors regulate the layer specificity but not the neuronal fate while bHLH activators determine the neuronal fate within the homedomain factor-specified layers. Thus, combinations of proper bHLH and homeodomain factors are required for neuronal subtype specification.Mesh：
Substances：
Year: 2004 PMID： 15036211 DOI： 10.1016/j.semcdb.2003.09.005
Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727