Literature DB >> 24951455

Alzheimer's disease risk genes and mechanisms of disease pathogenesis.

Celeste M Karch1, Alison M Goate2.   

Abstract

We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in AD pathogenesis. More recent advances in understanding of the human genome-technologic advances in methods to analyze millions of polymorphisms in thousands of subjects-have revealed new genes associated with AD risk, including ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-DBR1, INPP5D, MS4A, MEF2C, NME8, PICALM, PTK2B, SLC24H4-RIN3, SORL1, and ZCWPW1. Emerging technologies to analyze the entire genome in large data sets have also revealed coding variants that increase AD risk: PLD3 and TREM2. We review the relationship between these AD risk genes and the cellular and neuropathologic features of AD. Understanding the mechanisms underlying the association of these genes with risk for disease will provide the most meaningful targets for therapeutic development to date.
Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer’s Disease; Amyloid Precursor Protein; Cholesterol Metabolism; Endocytosis; Genome-Wide Association Studies; Immune Response

Mesh：

Substances：

Year:  2014        PMID： 24951455      PMCID： PMC4234692          DOI： 10.1016/j.biopsych.2014.05.006

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN： 0006-3223            Impact factor:   13.382


  149 in total

Review 1.  Roles of ATP-binding cassette transporter A7 in cholesterol homeostasis and host defense system.

Authors:  Nobukiyo Tanaka; Sumiko Abe-Dohmae; Noriyuki Iwamoto; Shinji Yokoyama
Journal:  J Atheroscler Thromb       Date:  2010-12-14       Impact factor: 4.928

2.  Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.

Authors:  Ana Griciuc; Alberto Serrano-Pozo; Antonio R Parrado; Andrea N Lesinski; Caroline N Asselin; Kristina Mullin; Basavaraj Hooli; Se Hoon Choi; Bradley T Hyman; Rudolph E Tanzi
Journal:  Neuron       Date:  2013-04-25       Impact factor: 17.173

Review 3.  The potential role of sialoadhesin as a macrophage recognition molecule in health and disease.

Authors:  P R Crocker; A Hartnell; J Munday; D Nath
Journal:  Glycoconj J       Date:  1997-08       Impact factor: 2.916

4.  Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.

Authors:  Dongming Cai; Minghao Zhong; Runsheng Wang; William J Netzer; Dennis Shields; Hui Zheng; Sangram S Sisodia; David A Foster; Fred S Gorelick; Huaxi Xu; Paul Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-31       Impact factor: 11.205

5.  Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.

Authors:  Britta Schürmann; Birgitt Wiese; Horst Bickel; Siegfried Weyerer; Steffi G Riedel-Heller; Michael Pentzek; Cadja Bachmann; Julie Williams; Hendrik van den Bussche; Wolfgang Maier; Frank Jessen
Journal:  J Alzheimers Dis       Date:  2011       Impact factor: 4.472

6.  TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease.

Authors:  Cyril Pottier; David Wallon; Stephane Rousseau; Anne Rovelet-Lecrux; Anne-Claire Richard; Adeline Rollin-Sillaire; Thierry Frebourg; Dominique Campion; Didier Hannequin
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

7.  Characterization of apolipoprotein J-Alzheimer's A beta interaction.

Authors:  E Matsubara; B Frangione; J Ghiso
Journal:  J Biol Chem       Date:  1995-03-31       Impact factor: 5.157

Review 8.  The role of apolipoprotein E in Alzheimer's disease.

Authors:  Jungsu Kim; Jacob M Basak; David M Holtzman
Journal:  Neuron       Date:  2009-08-13       Impact factor: 17.173

9.  Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors:  Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew J Huentelman; Amanda J Myers; Michael M Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Peter St George-Hyslop; Steven E Arnold; Robert Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W Dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan I Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael A Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg
Journal:  Nat Genet       Date:  2011-04-03       Impact factor: 38.330

Review 10.  Evidence for impaired amyloid β clearance in Alzheimer's disease.

Authors:  Kristin R Wildsmith; Monica Holley; Julie C Savage; Rebecca Skerrett; Gary E Landreth
Journal:  Alzheimers Res Ther       Date:  2013-07-12       Impact factor: 6.982
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  387 in total

1.  Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss.

Authors:  Santiago V Salazar; Timothy O Cox; Suho Lee; A Harrison Brody; Annabel S Chyung; Laura T Haas; Stephen M Strittmatter
Journal:  J Neurosci       Date:  2018-12-05       Impact factor: 6.167

2.  The Alzheimer's disease risk factor CD2AP maintains blood-brain barrier integrity.

Authors:  J Nicholas Cochran; Travis Rush; Susan C Buckingham; Erik D Roberson
Journal:  Hum Mol Genet       Date:  2015-09-10       Impact factor: 6.150

Review 3.  Dysregulation of Rab5-mediated endocytic pathways in Alzheimer's disease.

Authors:  Wei Xu; Fang Fang; Jianqing Ding; Chengbiao Wu
Journal:  Traffic       Date:  2018-02-05       Impact factor: 6.215

4.  Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer's Disease Risk?

Authors:  Polyxeni Stamati; Vasileios Siokas; Athina-Maria Aloizou; Emmanouil Karampinis; Stylianos Arseniou; Valerii N Rakitskii; Aristidis Tsatsakis; Demetrios A Spandidos; Illana Gozes; Panayiotis D Mitsias; Dimitrios P Bogdanos; Georgios M Hadjigeorgiou; Efthimios Dardiotis
Journal:  J Mol Neurosci       Date:  2019-07-02       Impact factor: 3.444

5.  Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer's Disease Subjects.

Authors:  Elizabeth M Ellison; Melissa A Bradley-Whitman; Mark A Lovell
Journal:  J Mol Neurosci       Date:  2017-09-02       Impact factor: 3.444

Review 6.  A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease.

Authors:  P Hemachandra Reddy; Sahil Tonk; Subodh Kumar; Murali Vijayan; Ramesh Kandimalla; Chandra Sekhar Kuruva; Arubala P Reddy
Journal:  Biochem Biophys Res Commun       Date:  2016-08-12       Impact factor: 3.575

7.  A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study.

Authors:  Ira Driscoll; Beverly M Snively; Mark A Espeland; Sally A Shumaker; Stephen R Rapp; Joseph S Goveas; Ramon L Casanova; Jean Wactawski-Wende; JoAnn E Manson; Rebecca Rossom; Janet Brooks; Dena G Hernandez; Andrew B Singleton; Susan M Resnick
Journal:  Int J Geriatr Psychiatry       Date:  2019-03-07       Impact factor: 3.485

Review 8.  Early-onset Alzheimer Disease and Its Variants.

Authors:  Mario F Mendez
Journal:  Continuum (Minneap Minn)       Date:  2019-02

Review 9.  Inflammatory Cytokines and Alzheimer's Disease: A Review from the Perspective of Genetic Polymorphisms.

Authors:  Fan Su; Feng Bai; Zhijun Zhang
Journal:  Neurosci Bull       Date:  2016-08-27       Impact factor: 5.203

10.  RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.

Authors:  Dimitry Ofengeim; Sonia Mazzitelli; Yasushi Ito; Judy Park DeWitt; Lauren Mifflin; Chengyu Zou; Sudeshna Das; Xian Adiconis; Hongbo Chen; Hong Zhu; Michelle A Kelliher; Joshua Z Levin; Junying Yuan
Journal:  Proc Natl Acad Sci U S A       Date:  2017-09-13       Impact factor: 11.205
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