Literature DB >> 29314494

Dysregulation of Rab5-mediated endocytic pathways in Alzheimer's disease.

Wei Xu1,2, Fang Fang1,2, Jianqing Ding1, Chengbiao Wu2.   

Abstract

Increasing evidence has pointed to that dysregulation of the endo-lysosomal system is an early cellular phenotype of pathogenesis for Alzheimer's disease (AD). Rab5, a small GTPase, plays a critical role in mediating these processes. Abnormal overactivation of Rab5 has been observed in post-mortem brain samples of Alzheimer's patients as well as brain samples of mouse models of AD. Recent genome-wide association studies of AD have identified RIN3 (Ras and Rab interactor 3) as a novel risk factor for the disease. RIN3 that functions as a guanine nucleotide exchange factor for Rab5 may serve as an important activator for Rab5 in AD pathogenesis. In this review, we present recent research highlights on the possible roles of dysregulation of Rab5-mediated endocytic pathways in contributing to early pathogenesis of AD.
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  Alzheimer's disease; Rab5; atrophy; axonal dysfunction; axonal transport; endocytosis; neurodegeneration

Mesh：

Substances：

Year:  2018        PMID： 29314494      PMCID： PMC5869093          DOI： 10.1111/tra.12547

Source DB:  PubMed          Journal:  Traffic        ISSN： 1398-9219            Impact factor:   6.215


  141 in total

1.  Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.

Authors:  Anne M Cataldo; Suzana Petanceska; Nicole B Terio; Corrinne M Peterhoff; Robert Durham; Marc Mercken; Pankaj D Mehta; Joseph Buxbaum; Vahram Haroutunian; Ralph A Nixon
Journal:  Neurobiol Aging       Date:  2004 Nov-Dec       Impact factor: 4.673

2.  Semagacestat for treatment of Alzheimer's disease.

Authors:  Rachelle S Doody; Paul S Aisen; Takeshi Iwatsubo
Journal:  N Engl J Med       Date:  2013-10-24       Impact factor: 91.245

3.  Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial.

Authors:  Serge Gauthier; Howard H Feldman; Lon S Schneider; Gordon K Wilcock; Giovanni B Frisoni; Jiri H Hardlund; Hans J Moebius; Peter Bentham; Karin A Kook; Damon J Wischik; Bjoern O Schelter; Charles S Davis; Roger T Staff; Luc Bracoud; Kohkan Shamsi; John M D Storey; Charles R Harrington; Claude M Wischik
Journal:  Lancet       Date:  2016-11-16       Impact factor: 79.321

4.  Rab5, an early acting endosomal GTPase, supports in vitro endosome fusion without GTP hydrolysis.

Authors:  M A Barbieri; G Li; M I Colombo; P D Stahl
Journal:  J Biol Chem       Date:  1994-07-22       Impact factor: 5.157

5.  Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells.

Authors:  C Haass; E H Koo; D B Teplow; D J Selkoe
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

6.  App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.

Authors:  Anne M Cataldo; Suzana Petanceska; Corrinne M Peterhoff; Nicole B Terio; Charles J Epstein; Angela Villar; Elaine J Carlson; Matthias Staufenbiel; Ralph A Nixon
Journal:  J Neurosci       Date:  2003-07-30       Impact factor: 6.167

7.  Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.

Authors:  Ayae Kinoshita; Hiroaki Fukumoto; Tejal Shah; Christa M Whelan; Michael C Irizarry; Bradley T Hyman
Journal:  J Cell Sci       Date:  2003-06-26       Impact factor: 5.285

8.  One at a time, live tracking of NGF axonal transport using quantum dots.

Authors:  Bianxiao Cui; Chengbiao Wu; Liang Chen; Alfredo Ramirez; Elaine L Bearer; Wei-Ping Li; William C Mobley; Steven Chu
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-14       Impact factor: 11.205

Review 9.  The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease.

Authors:  Joseph H Lee; Sandra Barral; Christiane Reitz
Journal:  Curr Neurol Neurosci Rep       Date:  2008-09       Impact factor: 5.081

10.  SorLA is a molecular link for retromer-dependent sorting of the Amyloid precursor protein.

Authors:  Anja W Fjorback; Olav M Andersen
Journal:  Commun Integr Biol       Date:  2012-11-01
View more
  25 in total

1.  Protein interacting with Amyloid Precursor Protein tail-1 (PAT1) is involved in early endocytosis.

Authors:  Aysegul Dilsizoglu Senol; Lidia Tagliafierro; Lucie Gorisse-Hussonnois; Florian Rebeillard; Léa Huguet; David Geny; Vincent Contremoulins; Fabian Corlier; Marie-Claude Potier; Stéphanie Chasseigneaux; Michèle Darmon; Bernadette Allinquant
Journal:  Cell Mol Life Sci       Date:  2019-05-28       Impact factor: 9.261

2.  [Progress on loss-of-function hypothesis of presenilin-1 mutations in Alzheimer diseases].

Authors:  Min Yan; Xu Wang; Xihan Guo
Journal:  Zhejiang Da Xue Xue Bao Yi Xue Ban       Date:  2020-08-25

3.  lncRNA HITT inhibits metastasis by attenuating Rab5-mediated endocytosis in lung adenocarcinoma.

Authors:  Xingwen Wang; Shanliang Zheng; Fan Yang; Wenxin Zhang; Dong Zhao; Xuting Xue; Qingyu Lin; Yunfei He; Guohong Hu; Ying Hu
Journal:  Mol Ther       Date:  2022-01-08       Impact factor: 11.454

4.  Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study.

Authors:  Xuan Zhou; Lili Yu; Lijuan Wang; Jiarui Xiao; Jing Sun; Yajing Zhou; Xiaolin Xu; Wanghong Xu; Athina Spiliopoulou; Maria Timofeeva; Xiaomeng Zhang; Yazhou He; Haomin Yang; Harry Campbell; Ben Zhang; Yimin Zhu; Evropi Theodoratou; Xue Li
Journal:  Eur J Epidemiol       Date:  2022-06-16       Impact factor: 12.434

5.  The Rab5-Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal Neurons.

Authors:  Andrés González-Gutiérrez; Oscar M Lazo; Francisca C Bronfman
Journal:  J Neurosci       Date:  2020-09-14       Impact factor: 6.167

6.  NOTCH-induced rerouting of endosomal trafficking disables regulatory T cells in vasculitis.

Authors:  Ke Jin; Zhenke Wen; Bowen Wu; Hui Zhang; Jingtao Qiu; Yanan Wang; Kenneth J Warrington; Gerald J Berry; Jorg J Goronzy; Cornelia M Weyand
Journal:  J Clin Invest       Date:  2021-01-04       Impact factor: 14.808

Review 7.  Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis.

Authors:  Jiqing Cao; Margaret B Zhong; Carlos A Toro; Larry Zhang; Dongming Cai
Journal:  Neurosci Lett       Date:  2019-03-16       Impact factor: 3.046

8.  Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease.

Authors:  Anna Pensalfini; Seonil Kim; Shivakumar Subbanna; Cynthia Bleiwas; Chris N Goulbourne; Philip H Stavrides; Ying Jiang; Ju-Hyun Lee; Sandipkumar Darji; Monika Pawlik; Chunfeng Huo; James Peddy; Martin J Berg; John F Smiley; Balapal S Basavarajappa; Ralph A Nixon
Journal:  Cell Rep       Date:  2020-11-24       Impact factor: 9.423

9.  The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism.

Authors:  Thomas C Buckles; Yohei Ohashi; Shirley Tremel; Stephen H McLaughlin; Els Pardon; Jan Steyaert; Moshe T Gordon; Roger L Williams; Joseph J Falke
Journal:  Biophys J       Date:  2020-10-31       Impact factor: 4.033

Review 10.  Small GTPases of the Rab and Arf Families: Key Regulators of Intracellular Trafficking in Neurodegeneration.

Authors:  Alazne Arrazola Sastre; Miriam Luque Montoro; Hadriano M Lacerda; Francisco Llavero; José L Zugaza
Journal:  Int J Mol Sci       Date:  2021-04-23       Impact factor: 5.923
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.