| Literature DB >> 31267315 |
Polyxeni Stamati1, Vasileios Siokas1, Athina-Maria Aloizou1, Emmanouil Karampinis1, Stylianos Arseniou1, Valerii N Rakitskii2, Aristidis Tsatsakis3, Demetrios A Spandidos4, Illana Gozes5, Panayiotis D Mitsias6, Dimitrios P Bogdanos7,8, Georgios M Hadjigeorgiou1,9, Efthimios Dardiotis10.
Abstract
Α number of genetic variants have been associated with Alzheimer's disease (AD) susceptibility. Sec1 family domain-containing protein 1 (SCFD1) gene polymorphism rs10139154 has recently been implicated in the risk of developing amyotrophic lateral sclerosis (ALS). Similarities in the pathogenetic cascade of both diseases have also been described. The present study was designed to evaluate the possible contribution of SCFD1 rs10139154 to AD. A total of 327 patients with AD and an equal number of healthy controls were included in the study and genotyped for rs10139154. With logistic regression analyses, rs10139154 was examined for the association with the risk of developing AD. In the recessive mode, SCFD1 rs10139154 was associated with a decreased risk of developing AD (odds ratio (OR) (95% confidence interval (CI)) = 0.63 (0.40-0.97), p = 0.036). The current study provides preliminary evidence of the involvement of SCFD1 rs10139154 in the risk of developing AD.Entities:
Keywords: AD; Genetics; Polymorphism; SCFD1; SNPs
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Year: 2019 PMID： 31267315 DOI： 10.1007/s12031-019-01363-3
Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444