Literature DB >> 24935090

Auranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains.

Yozane Hokai1, Boruch Jurkowicz2, Jacob Fernández-Gallardo3, Nuruddinkodja Zakirkhodjaev2, Mercedes Sanaú4, Theodore R Muth2, María Contel5.   

Abstract

A series of new heterometallic gold(I) thiolates containing ferrocenyl-phoshines were synthesized. Their antimicrobial properties were studied and compared to that of FDA-approved drug, auranofin (Ridaura), prescribed for the treatment of rheumatoid arthritis. MIC in the order of one digit micromolar were found for most of the compounds against Gram-positive bacteria Staphylococcus aureus and CA MRSA strains US300 and US400. Remarkably, auranofin inhibited S. aureus, US300 and US400 in the order of 150-300 nM. This is the first time that the potent inhibitory effect of auranofin on MRSA strains has been described. The effects of a selected heterometallic compound and auranofin were also studied in a non-tumorigenic human embryonic kidney cell line (HEK-293).
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Antimicrobial; Auranofin; Heterometallic gold–thiolates; MRSA

Mesh：

Substances：

Year:  2014        PMID： 24935090      PMCID： PMC4139291          DOI： 10.1016/j.jinorgbio.2014.05.008

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


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