Literature DB >> 27268469

Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.

Nathan P Wiederhold1,2, Thomas F Patterson2,3, Anand Srinivasan4,5, Ashok K Chaturvedi5,6, Annette W Fothergill1, Floyd L Wormley5,6, Anand K Ramasubramanian4,5, José L Lopez-Ribot5,6.   

Abstract

Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important fungi.

Entities:  

Keywords:  antifungal susceptibility; auranofin; repurposing; spectrum of action

Mesh：

Substances：

Year:  2016        PMID： 27268469      PMCID： PMC5354159          DOI： 10.1080/21505594.2016.1196301

Source DB:  PubMed          Journal:  Virulence        ISSN： 2150-5594            Impact factor:   5.882


  19 in total

Review 1.  Antifungal agents: mechanisms of action.

Authors:  Frank C Odds; Alistair J P Brown; Neil A R Gow
Journal:  Trends Microbiol       Date:  2003-06       Impact factor: 17.079

Review 2.  An insight into the antifungal pipeline: selected new molecules and beyond.

Authors:  Luis Ostrosky-Zeichner; Arturo Casadevall; John N Galgiani; Frank C Odds; John H Rex
Journal:  Nat Rev Drug Discov       Date:  2010-08-20       Impact factor: 84.694

Review 3.  Antifungal therapy with an emphasis on biofilms.

Authors:  Christopher G Pierce; Anand Srinivasan; Priya Uppuluri; Anand K Ramasubramanian; José L López-Ribot
Journal:  Curr Opin Pharmacol       Date:  2013-09-04       Impact factor: 5.547

4.  Auranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains.

Authors:  Yozane Hokai; Boruch Jurkowicz; Jacob Fernández-Gallardo; Nuruddinkodja Zakirkhodjaev; Mercedes Sanaú; Theodore R Muth; María Contel
Journal:  J Inorg Biochem       Date:  2014-05-28       Impact factor: 4.155

5.  New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications.

Authors:  Anna Rosa Sannella; Angela Casini; Chiara Gabbiani; Luigi Messori; Anna Rita Bilia; Francesco Franco Vincieri; Giancarlo Majori; Carlo Severini
Journal:  FEBS Lett       Date:  2008-02-21       Impact factor: 4.124

6.  Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects.

Authors:  Francesco Angelucci; Ahmed A Sayed; David L Williams; Giovanna Boumis; Maurizio Brunori; Daniela Dimastrogiovanni; Adriana E Miele; Frida Pauly; Andrea Bellelli
Journal:  J Biol Chem       Date:  2009-08-26       Impact factor: 5.157

7.  High-throughput screening of a collection of known pharmacologically active small compounds for identification of Candida albicans biofilm inhibitors.

Authors:  Samuel A Siles; Anand Srinivasan; Christopher G Pierce; José L Lopez-Ribot; Anand K Ramasubramanian
Journal:  Antimicrob Agents Chemother       Date:  2013-05-20       Impact factor: 5.191

8.  A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia.

Authors:  Noa Tejman-Yarden; Yukiko Miyamoto; David Leitsch; Jennifer Santini; Anjan Debnath; Jiri Gut; James H McKerrow; Sharon L Reed; Lars Eckmann
Journal:  Antimicrob Agents Chemother       Date:  2013-02-12       Impact factor: 5.191

9.  Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin.

Authors:  Beth Burgwyn Fuchs; Rajmohan RajaMuthiah; Ana Carolina Remondi Souza; Soraya Eatemadpour; Rodnei Dennis Rossoni; Daniel Assis Santos; Juliana C Junqueira; Louis B Rice; Eleftherios Mylonakis
Journal:  Future Med Chem       Date:  2016-01-25       Impact factor: 3.808

10.  A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.

Authors:  Anjan Debnath; Derek Parsonage; Rosa M Andrade; Chen He; Eduardo R Cobo; Ken Hirata; Steven Chen; Guillermina García-Rivera; Esther Orozco; Máximo B Martínez; Shamila S Gunatilleke; Amy M Barrios; Michelle R Arkin; Leslie B Poole; James H McKerrow; Sharon L Reed
Journal:  Nat Med       Date:  2012-06       Impact factor: 53.440
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  26 in total

1.  Identification of Off-Patent Drugs That Show Synergism with Amphotericin B or That Present Antifungal Action against Cryptococcus neoformans and Candida spp.

Authors:  Suélen Andreia Rossi; Haroldo Cesar de Oliveira; Daniel Agreda-Mellon; José Lucio; Maria José Soares Mendes-Giannini; Jesús Pablo García-Cambero; Oscar Zaragoza
Journal:  Antimicrob Agents Chemother       Date:  2020-03-24       Impact factor: 5.191

Review 2.  Screening Repurposing Libraries for Identification of Drugs with Novel Antifungal Activity.

Authors:  Gina Wall; Jose L Lopez-Ribot
Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191

3.  The unmet clinical need of novel antifungal drugs.

Authors:  Damian J Krysan
Journal:  Virulence       Date:  2017-02-17       Impact factor: 5.882

4.  Screening the Pathogen Box for Identification of Candida albicans Biofilm Inhibitors.

Authors:  Taissa Vila; Jose L Lopez-Ribot
Journal:  Antimicrob Agents Chemother       Date:  2016-12-27       Impact factor: 5.191

5.  Repurposing of Ribavirin as an Adjunct Therapy against Invasive Candida Strains in an In Vitro Study.

Authors:  Hanane Yousfi; Carole Cassagne; Stéphane Ranque; Jean-Marc Rolain; Fadi Bittar
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

Review 6.  Emerging and future strategies in the management of recalcitrant Candida auris.

Authors:  Nihal Bandara; Lakshman Samaranayake
Journal:  Med Mycol       Date:  2022-03-17       Impact factor: 4.076

7.  Synthesis and Structure-Activity Relationship Study of Antimicrobial Auranofin against ESKAPE Pathogens.

Authors:  Bin Wu; Xiaojian Yang; Mingdi Yan
Journal:  J Med Chem       Date:  2019-08-21       Impact factor: 7.446

8.  Current and promising pharmacotherapeutic options for candidiasis.

Authors:  Liliana Scorzoni; Beth Burgwyn Fuchs; Juliana Campos Junqueira; Eleftherios Mylonakis
Journal:  Expert Opin Pharmacother       Date:  2021-02-04       Impact factor: 3.889

Review 9.  One Century of Study: What We Learned about Paracoccidioides and How This Pathogen Contributed to Advances in Antifungal Therapy.

Authors:  Erika Seki Kioshima; Patrícia de Souza Bonfim de Mendonça; Marcus de Melo Teixeira; Isis Regina Grenier Capoci; André Amaral; Franciele Abigail Vilugron Rodrigues-Vendramini; Bruna Lauton Simões; Ana Karina Rodrigues Abadio; Larissa Fernandes Matos; Maria Sueli Soares Felipe
Journal:  J Fungi (Basel)       Date:  2021-02-02

Review 10.  Drug Repurposing in Medical Mycology: Identification of Compounds as Potential Antifungals to Overcome the Emergence of Multidrug-Resistant Fungi.

Authors:  Lucie Peyclit; Hanane Yousfi; Jean-Marc Rolain; Fadi Bittar
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-20
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