Literature DB >> 30108879

Biscarbene gold(i) complexes: structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability.

Claudia Schmidt1, Bianka Karge2, Rainer Misgeld3, Aram Prokop3, Mark Brönstrup2, Ingo Ott1.   

Abstract

A series of gold(i) complexes with two N-heterocyclic carbene ligands (biscarbene gold complexes) were prepared and evaluated for their effects against cancer cells and pathogenic bacteria. Proliferation inhibition was observed in cancer cells and in Gram-positive bacteria, whereas Gram-negative bacteria were less sensitive towards the compounds. The protein binding and cellular uptake were quantified and the combined results indicated a strong correlation between cellular bioavailability and antiproliferative effects. The biscarbene gold complexes inhibited bacterial and mammalian TrxRs with low to moderate potency. However, based on the obtained structure-activity-relationships and the high cellular accumulation levels, TrxR inhibition can be considered as a relevant contributor to the cellular pharmacology of biscarbene gold(i) complexes.

Entities:  

Year:  2017        PMID： 30108879      PMCID： PMC6072206          DOI： 10.1039/c7md00269f

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  35 in total

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2.  Inhibition Mechanism of Urease by Au(III) Compounds Unveiled by X-ray Diffraction Analysis.

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3.  Crystal structures of the gold NHC complex bis-(4-bromo-1,3-di-ethyl-imidazol-2-yl-idene)gold(I) iodide and its 1:1 adduct with trans-bis-(4-bromo-1,3-diethyl-imidazol-2-yl-idene)di-iodido-gold(III) iodide.

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7.  Antibacterial Thiamine inspired silver (I) and gold (I) N-heterocyclic carbene compounds.

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