Valdeci Elias dos Santos1, Arnoldo Vasconcelos Filho2, Andrea Gadelha Ribeiro Targino3, Miguel Angel Pelagio Flores4, André Galembeck5, Arnaldo França Caldas6, Aronita Rosenblatt7. 1. University of Pernambuco, Pediatric Dentistry, Brazil. Electronic address: valdeciodonto@hotmail.com. 2. Department of Paediatric Dentistry, Faculty of Dentistry, University of Pernambuco, Brazil. Electronic address: arnoldo_filho@terra.com.br. 3. Department of Paediatric Dentistry, Faculty of Dentistry, University of Pernambuco, Brazil. Electronic address: andreadoutorado@gmail.com. 4. Federal University of Pernambuco, Department of Fundamental Chemistry Center for Strategic Technologies of Northeast , CETENE - INT/MCTI, Recife - PE, Brazil. Electronic address: mpelagio@gmail.com. 5. Federal University of Pernambuco, Department of Fundamental Chemistry Center for Strategic Technologies of Northeast , CETENE - INT/MCTI, Recife - PE, Brazil. Electronic address: andre@cetene.gov.br. 6. Federal University of Pernambuco, Brazil. Electronic address: caldasjr@aldeia.com.br. 7. Faculty of Dentistry, University of Pernambuco, Brazil. Electronic address: aronita.rosenblatt@gmail.com.
Abstract
BACKGROUND: Untreated dental caries in children remains a public health challenge in poor communities. OBJECTIVES: This prospective controlled clinical trial investigated the effectiveness of a new anti-caries agent, Nano Silver Fluoride (NSF), applied once a year to arrest caries in children. METHODS:One hundred thirty decayed primary teeth were randomly divided into two groups: NSF as the experimental agent and water as the control group. Teeth were clinically diagnosed and treated by one masked examiner and followed up at seven days and five and 12 months by another calibrated examiner who was blinded to the type of treatment. The criteria of the ICDAS II were followed to determine the activity of lesion and the diagnosis of caries. The Pearson's chi-square test was used to compare the groups during different follow-up exams. RESULTS: At seven days, 81% of teeth in the NSF group exhibited arrested caries, whereas in controls, no teeth had arrested decay (p<0.001) [PF, prevented fraction=81%]. After five months, the NSF group had 72.7% with arrested decay, and the control group had 27.4% (p<0.001) [PF=62.5%]. At 12 months, 66.7% of the lesions treated with NSF were still arrested, while the control group had 34.7% remaining arrested (p=0.003) [PF=50%]. The number need to treat (NNT) at five months was two, and at 12 months, the number was three. CLINICAL SIGNIFICANCE: The NSF formulation is effective to arrest active dentine caries and not stain teeth. CONCLUSIONS:NSF was demonstrated to be effective in arresting caries in children in poor communities.
RCT Entities:
BACKGROUND: Untreated dental caries in children remains a public health challenge in poor communities. OBJECTIVES: This prospective controlled clinical trial investigated the effectiveness of a new anti-caries agent, Nano Silver Fluoride (NSF), applied once a year to arrest caries in children. METHODS: One hundred thirty decayed primary teeth were randomly divided into two groups: NSF as the experimental agent and water as the control group. Teeth were clinically diagnosed and treated by one masked examiner and followed up at seven days and five and 12 months by another calibrated examiner who was blinded to the type of treatment. The criteria of the ICDAS II were followed to determine the activity of lesion and the diagnosis of caries. The Pearson's chi-square test was used to compare the groups during different follow-up exams. RESULTS: At seven days, 81% of teeth in the NSF group exhibited arrested caries, whereas in controls, no teeth had arrested decay (p<0.001) [PF, prevented fraction=81%]. After five months, the NSF group had 72.7% with arrested decay, and the control group had 27.4% (p<0.001) [PF=62.5%]. At 12 months, 66.7% of the lesions treated with NSF were still arrested, while the control group had 34.7% remaining arrested (p=0.003) [PF=50%]. The number need to treat (NNT) at five months was two, and at 12 months, the number was three. CLINICAL SIGNIFICANCE: The NSF formulation is effective to arrest active dentine caries and not stain teeth. CONCLUSIONS: NSF was demonstrated to be effective in arresting caries in children in poor communities.
Authors: Walid K Hamoudi; Zinah S Shakir; Raid A Ismail; Hassanien A Al-Jumaily; Shama Anees Sahib; Abdullah R Abedulwahhab Journal: J Lasers Med Sci Date: 2021-12-26
Authors: Fernando Luis Esteban Florez; Rochelle Denise Hiers; Preston Larson; Matthew Johnson; Edgar O'Rear; Adam J Rondinone; Sharukh Soli Khajotia Journal: Mater Sci Eng C Mater Biol Appl Date: 2018-09-01 Impact factor: 7.328
Authors: Irene Shuping Zhao; Iris Xiaoxue Yin; May Lei Mei; Edward Chin Man Lo; Jinyao Tang; Quanli Li; Lok Yan So; Chun Hung Chu Journal: Int J Nanomedicine Date: 2020-04-23
Authors: Iris Xiaoxue Yin; Irene Shuping Zhao; May Lei Mei; Edward Chin Man Lo; Jinyao Tang; Quanli Li; Lok Yan So; Chun Hung Chu Journal: Int J Nanomedicine Date: 2020-05-06