| Literature DB >> 24929828 |
Daan W Loth1, María Soler Artigas2, Sina A Gharib3, Louise V Wain2, Nora Franceschini4, Beate Koch5, Tess D Pottinger6, Albert Vernon Smith7, Qing Duan8, Chris Oldmeadow9, Mi Kyeong Lee10, David P Strachan11, Alan L James12, Jennifer E Huffman13, Veronique Vitart13, Adaikalavan Ramasamy14, Nicholas J Wareham15, Jaakko Kaprio16, Xin-Qun Wang17, Holly Trochet13, Mika Kähönen18, Claudia Flexeder19, Eva Albrecht20, Lorna M Lopez21, Kim de Jong22, Bharat Thyagarajan23, Alexessander Couto Alves24, Stefan Enroth25, Ernst Omenaas26, Peter K Joshi27, Tove Fall28, Ana Viñuela29, Lenore J Launer30, Laura R Loehr31, Myriam Fornage32, Guo Li33, Jemma B Wilk34, Wenbo Tang35, Ani Manichaikul36, Lies Lahousse37, Tamara B Harris30, Kari E North38, Alicja R Rudnicka11, Jennie Hui39, Xiangjun Gu32, Thomas Lumley40, Alan F Wright13, Nicholas D Hastie13, Susan Campbell13, Rajesh Kumar41, Isabelle Pin42, Robert A Scott15, Kirsi H Pietiläinen43, Ida Surakka44, Yongmei Liu45, Elizabeth G Holliday9, Holger Schulz19, Joachim Heinrich46, Gail Davies47, Judith M Vonk22, Mary Wojczynski48, Anneli Pouta49, Asa Johansson50, Sarah H Wild27, Erik Ingelsson51, Fernando Rivadeneira52, Henry Völzke53, Pirro G Hysi29, Gudny Eiriksdottir54, Alanna C Morrison55, Jerome I Rotter56, Wei Gao57, Dirkje S Postma58, Wendy B White59, Stephen S Rich60, Albert Hofman61, Thor Aspelund62, David Couper63, Lewis J Smith41, Bruce M Psaty64, Kurt Lohman65, Esteban G Burchard66, André G Uitterlinden67, Melissa Garcia30, Bonnie R Joubert68, Wendy L McArdle69, A Bill Musk70, Nadia Hansel71, Susan R Heckbert72, Lina Zgaga73, Joyce B J van Meurs52, Pau Navarro13, Igor Rudan27, Yeon-Mok Oh74, Susan Redline75, Deborah L Jarvis76, Jing Hua Zhao15, Taina Rantanen77, George T O'Connor78, Samuli Ripatti79, Rodney J Scott9, Stefan Karrasch80, Harald Grallert81, Nathan C Gaddis82, John M Starr83, Cisca Wijmenga84, Ryan L Minster85, David J Lederer86, Juha Pekkanen87, Ulf Gyllensten25, Harry Campbell27, Andrew P Morris88, Sven Gläser89, Christopher J Hammond29, Kristin M Burkart90, John Beilby39, Stephen B Kritchevsky91, Vilmundur Gudnason62, Dana B Hancock92, O Dale Williams93, Ozren Polasek94, Tatijana Zemunik95, Ivana Kolcic94, Marcy F Petrini96, Matthias Wjst97, Woo Jin Kim98, David J Porteous99, Generation Scotland100, Blair H Smith101, Anne Viljanen77, Markku Heliövaara102, John R Attia9, Ian Sayers103, Regina Hampel104, Christian Gieger20, Ian J Deary21, H Marike Boezen22, Anne Newman105, Marjo-Riitta Jarvelin106, James F Wilson27, Lars Lind107, Bruno H Stricker108, Alexander Teumer109, Timothy D Spector29, Erik Melén110, Marjolein J Peters52, Leslie A Lange111, R Graham Barr86, Ken R Bracke112, Fien M Verhamme112, Joohon Sung113, Pieter S Hiemstra114, Patricia A Cassano115, Akshay Sood116, Caroline Hayward117, Josée Dupuis118, Ian P Hall119, Guy G Brusselle120, Martin D Tobin2, Stephanie J London121.
Abstract
Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.Entities:
Mesh：
Year: 2014 PMID： 24929828 PMCID： PMC4140093 DOI： 10.1038/ng.3011
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330