M Harries1, A Taylor2, L Holmberg3, O Agbaje3, H Garmo3, S Kabilan3, A Purushotham4. 1. Department of Medical Oncology, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom. Electronic address: mark.harries@gstt.nhs.uk. 2. Centre for Observational Research, Amgen Limited, 1 Uxbridge Business Park, Sanderson Road, Uxbridge UB8 1DH, United Kingdom. 3. King's College London School of Medicine, Division of Cancer Studies, Cancer Epidemiology Unit, Research Oncology, 3rd Floor Bermondsey Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom. 4. King's College London School of Medicine, Division of Cancer Studies, Research Oncology, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom.
Abstract
BACKGROUND: Bone is the most common metastatic site associated with breast cancer. Using a database of women with breast cancer treated at Guy's Hospital, London 1976-2006 and followed until end 2010, we determined incidence of and survival after bone metastases. METHODS: We calculated cumulative incidence of bone metastases considering death without prior bone metastases as a competing risk. Risk of bone metastases was modelled through Cox-regression. Survival after bone metastases diagnosis was calculated using Kaplan-Meier methodology. RESULTS: Of the 7064 women, 589 (22%) developed bone metastases during 8.4 years (mean). Incidence of bone metastases was significantly higher in younger women, tumour size >5 cm, higher tumour grade, lobular carcinoma and ≥ four positive nodes, but was not affected by hormone receptor status. Median survival after bone metastases diagnosis was 2.3 years in women with bone-only metastases compared with <1 year in women with visceral and bone metastases. There was a trend for decreased survival for patients who developed visceral metastases early, and proportionately fewer patients in this group. INTERPRETATION: Incidence of bone metastases has decreased but bone metastases remain a highly relevant clinical problem due to the large number of patients being diagnosed with breast cancer.
BACKGROUND: Bone is the most common metastatic site associated with breast cancer. Using a database of women with breast cancer treated at Guy's Hospital, London 1976-2006 and followed until end 2010, we determined incidence of and survival after bone metastases. METHODS: We calculated cumulative incidence of bone metastases considering death without prior bone metastases as a competing risk. Risk of bone metastases was modelled through Cox-regression. Survival after bone metastases diagnosis was calculated using Kaplan-Meier methodology. RESULTS: Of the 7064 women, 589 (22%) developed bone metastases during 8.4 years (mean). Incidence of bone metastases was significantly higher in younger women, tumour size >5 cm, higher tumour grade, lobular carcinoma and ≥ four positive nodes, but was not affected by hormone receptor status. Median survival after bone metastases diagnosis was 2.3 years in women with bone-only metastases compared with <1 year in women with visceral and bone metastases. There was a trend for decreased survival for patients who developed visceral metastases early, and proportionately fewer patients in this group. INTERPRETATION: Incidence of bone metastases has decreased but bone metastases remain a highly relevant clinical problem due to the large number of patients being diagnosed with breast cancer.
Authors: Willemijne A M E Schrijver; Petra van der Groep; Laurien Dc Hoefnagel; Natalie D Ter Hoeve; Ton Peeters; Cathy B Moelans; Paul J van Diest Journal: Mod Pathol Date: 2016-08-26 Impact factor: 7.842
Authors: Lanell M Peterson; Janet O'Sullivan; Qian Vicky Wu; Alena Novakova-Jiresova; Isaac Jenkins; Jean H Lee; Andrew Shields; Susan Montgomery; Hannah M Linden; Julie Gralow; Vijayakrishna K Gadi; Mark Muzi; Paul Kinahan; David Mankoff; Jennifer M Specht Journal: J Nucl Med Date: 2018-05-10 Impact factor: 10.057