Literature DB >> 24916387

C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47.

Nicolas Fossat1, Karin Tourle2, Tania Radziewic2, Kristen Barratt2, Doreen Liebhold2, Joshua B Studdert2, Melinda Power2, Vanessa Jones2, David A F Loebel3, Patrick P L Tam3.   

Abstract

Cytidine (C) to Uridine (U) RNA editing is a post-transcriptional modification that is accomplished by the deaminase APOBEC1 and its partnership with the RNA-binding protein A1CF. We identify and characterise here a novel RNA-binding protein, RBM47, that interacts with APOBEC1 and A1CF and is expressed in tissues where C to U RNA editing occurs. RBM47 can substitute for A1CF and is necessary and sufficient for APOBEC1-mediated editing in vitro. Editing is further impaired in Rbm47-deficient mutant mice. These findings suggest that RBM47 and APOBEC1 constitute the basic machinery for C to U RNA editing.
© 2014 The Authors.

Entities:  

Keywords:  APOBEC1; Apolipoprotein b; RBM47; RNA editing; intestine

Mesh：

Substances：

Year:  2014        PMID： 24916387      PMCID： PMC4197048          DOI： 10.15252/embr.201438450

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  21 in total

1.  Protein composition of catalytically active human telomerase from immortal cells.

Authors:  Scott B Cohen; Mark E Graham; George O Lovrecz; Nicolai Bache; Phillip J Robinson; Roger R Reddel
Journal:  Science       Date:  2007-03-30       Impact factor: 47.728

Review 2.  Diagnosis and treatment of apolipoprotein B dyslipoproteinemias.

Authors:  Allan Sniderman; Patrick Couture; Jacqueline de Graaf
Journal:  Nat Rev Endocrinol       Date:  2010-04-27       Impact factor: 43.330

Review 3.  APOBEC-1-mediated RNA editing.

Authors:  Valerie Blanc; Nicholas O Davidson
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2010 Sep-Oct

4.  Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality.

Authors:  Valerie Blanc; Jeffrey O Henderson; Elizabeth P Newberry; Susan Kennedy; Jianyang Luo; Nicholas O Davidson
Journal:  Mol Cell Biol       Date:  2005-08       Impact factor: 4.272

5.  ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components.

Authors:  Zhigang Chen; Thomas L Eggerman; Amy P Patterson
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2006-08-17       Impact factor: 4.052

6.  The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase.

Authors:  N Navaratnam; J R Morrison; S Bhattacharya; D Patel; T Funahashi; F Giannoni; B B Teng; N O Davidson; J Scott
Journal:  J Biol Chem       Date:  1993-10-05       Impact factor: 5.157

7.  Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of Apobec-1.

Authors:  M Nakamuta; B H Chang; E Zsigmond; K Kobayashi; H Lei; B Y Ishida; K Oka; E Li; L Chan
Journal:  J Biol Chem       Date:  1996-10-18       Impact factor: 5.157

8.  Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48.

Authors:  K Hirano; S G Young; R V Farese; J Ng; E Sande; C Warburton; L M Powell-Braxton; N O Davidson
Journal:  J Biol Chem       Date:  1996-04-26       Impact factor: 5.157

9.  Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3' UTRs.

Authors:  Brad R Rosenberg; Claire E Hamilton; Michael M Mwangi; Scott Dewell; F Nina Papavasiliou
Journal:  Nat Struct Mol Biol       Date:  2011-01-23       Impact factor: 15.369

10.  iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution.

Authors:  Julian König; Kathi Zarnack; Gregor Rot; Tomaz Curk; Melis Kayikci; Blaz Zupan; Daniel J Turner; Nicholas M Luscombe; Jernej Ule
Journal:  Nat Struct Mol Biol       Date:  2010-07-04       Impact factor: 15.369
View more
  44 in total

1.  Genetic Architectures of Quantitative Variation in RNA Editing Pathways.

Authors:  Tongjun Gu; Daniel M Gatti; Anuj Srivastava; Elizabeth M Snyder; Narayanan Raghupathy; Petr Simecek; Karen L Svenson; Ivan Dotu; Jeffrey H Chuang; Mark P Keller; Alan D Attie; Robert E Braun; Gary A Churchill
Journal:  Genetics       Date:  2015-11-27       Impact factor: 4.562

2.  Functional requirements of AID's higher order structures and their interaction with RNA-binding proteins.

Authors:  Samiran Mondal; Nasim A Begum; Wenjun Hu; Tasuku Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-29       Impact factor: 11.205

3.  Re-editing the paradigm of Cytidine (C) to Uridine (U) RNA editing.

Authors:  Nicolas Fossat; Patrick P L Tam
Journal:  RNA Biol       Date:  2014       Impact factor: 4.652

4.  Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase.

Authors:  Wenjun Hu; Nasim A Begum; Samiran Mondal; Andre Stanlie; Tasuku Honjo
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-20       Impact factor: 11.205

5.  Comparison of RNA Editing Activity of APOBEC1-A1CF and APOBEC1-RBM47 Complexes Reconstituted in HEK293T Cells.

Authors:  Aaron D Wolfe; Don B Arnold; Xiaojiang S Chen
Journal:  J Mol Biol       Date:  2019-03-04       Impact factor: 5.469

6.  RBM47-regulated alternative splicing of TJP1 promotes actin stress fiber assembly during epithelial-to-mesenchymal transition.

Authors:  Yong-Eun Kim; Minho Won; Sung-Gwon Lee; Chungoo Park; Chang-Hwa Song; Kee K Kim
Journal:  Oncogene       Date:  2019-07-29       Impact factor: 9.867

Review 7.  RNA binding motif 47 (RBM47): emerging roles in vertebrate development, RNA editing and cancer.

Authors:  Pavan Kumar Mysuru Shivalingappa; Vaishali Sharma; Anjali Shiras; Sharmila A Bapat
Journal:  Mol Cell Biochem       Date:  2021-09-09       Impact factor: 3.396

8.  Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology.

Authors:  Daniel C Cole; Youngcheul Chung; Khatuna Gagnidze; Kaitlyn H Hajdarovic; Violeta Rayon-Estrada; Dewi Harjanto; Benedetta Bigio; Judit Gal-Toth; Teresa A Milner; Bruce S McEwen; F Nina Papavasiliou; Karen Bulloch
Journal:  Proc Natl Acad Sci U S A       Date:  2017-11-22       Impact factor: 11.205

Review 9.  The APOBEC Protein Family: United by Structure, Divergent in Function.

Authors:  Jason D Salter; Ryan P Bennett; Harold C Smith
Journal:  Trends Biochem Sci       Date:  2016-06-06       Impact factor: 13.807

10.  Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition.

Authors:  Yueqin Yang; Juw Won Park; Thomas W Bebee; Claude C Warzecha; Yang Guo; Xuequn Shang; Yi Xing; Russ P Carstens
Journal:  Mol Cell Biol       Date:  2016-05-16       Impact factor: 4.272
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.