Literature DB >> 24910580

Correcting systemic deficiencies in our scientific infrastructure.

Mohan Doss1.   

Abstract

Scientific method is inherently self-correcting. When different hypotheses are proposed, their study would result in the rejection of the invalid ones. If the study of a competing hypothesis is prevented because of the faith in an unverified one, scientific progress is stalled. This has happened in the study of low dose radiation. Though radiation hormesis was hypothesized to reduce cancers in 1980, it could not be studied in humans because of the faith in the unverified linear no-threshold model hypothesis, likely resulting in over 15 million preventable cancer deaths worldwide during the past two decades, since evidence has accumulated supporting the validity of the phenomenon of radiation hormesis. Since our society has been guided by scientific advisory committees that ostensibly follow the scientific method, the long duration of such large casualties is indicative of systemic deficiencies in the infrastructure that has evolved in our society for the application of science. Some of these deficiencies have been identified in a few elements of the scientific infrastructure, and remedial steps suggested. Identifying and correcting such deficiencies may prevent similar tolls in the future.

Entities:  

Keywords:  LNT Model; Radiation Hormesis; Scientific Infrastructure; Scientific Method

Year:  2013        PMID: 24910580      PMCID: PMC4036394          DOI: 10.2203/dose-response.13-046.Doss

Source DB:  PubMed          Journal:  Dose Response        ISSN: 1559-3258            Impact factor:   2.658


  69 in total

1.  The 2007 Recommendations of the International Commission on Radiological Protection. ICRP publication 103.

Authors: 
Journal:  Ann ICRP       Date:  2007

2.  Micro RNA responses to chronic or acute exposures to low dose ionizing radiation.

Authors:  M Ahmad Chaudhry; Romaica A Omaruddin; Bridget Kreger; Sonia M de Toledo; Edouard I Azzam
Journal:  Mol Biol Rep       Date:  2012-02-25       Impact factor: 2.316

Review 3.  Energy and human health.

Authors:  Kirk R Smith; Howard Frumkin; Kalpana Balakrishnan; Colin D Butler; Zoë A Chafe; Ian Fairlie; Patrick Kinney; Tord Kjellstrom; Denise L Mauzerall; Thomas E McKone; Anthony J McMichael; Mycle Schneider
Journal:  Annu Rev Public Health       Date:  2013-01-16       Impact factor: 21.981

4.  The importance of adaptive response in cancer prevention and therapy.

Authors:  Mohan Doss
Journal:  Med Phys       Date:  2013-03       Impact factor: 4.071

5.  In vivo γ-irradiation low dose threshold for suppression of DNA double strand breaks below the spontaneous level in mouse blood and spleen cells.

Authors:  Andreyan N Osipov; Galina Buleeva; Ekaterina Arkhangelskaya; Dmitry Klokov
Journal:  Mutat Res       Date:  2013-05-08       Impact factor: 2.433

6.  Experimental study of alleviation of hypertension, diabetes and pain by radon inhalation.

Authors:  K Yamaoka; Y Komoto
Journal:  Physiol Chem Phys Med NMR       Date:  1996

7.  Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries.

Authors:  E Cardis; M Vrijheid; M Blettner; E Gilbert; M Hakama; C Hill; G Howe; J Kaldor; C R Muirhead; M Schubauer-Berigan; T Yoshimura; F Bermann; G Cowper; J Fix; C Hacker; B Heinmiller; M Marshall; I Thierry-Chef; D Utterback; Y-O Ahn; E Amoros; P Ashmore; A Auvinen; J-M Bae; J Bernar Solano; A Biau; E Combalot; P Deboodt; A Diez Sacristan; M Eklof; H Engels; G Engholm; G Gulis; R Habib; K Holan; H Hyvonen; A Kerekes; J Kurtinaitis; H Malker; M Martuzzi; A Mastauskas; A Monnet; M Moser; M S Pearce; D B Richardson; F Rodriguez-Artalejo; A Rogel; H Tardy; M Telle-Lamberton; I Turai; M Usel; K Veress
Journal:  BMJ       Date:  2005-06-29

8.  Adaptive immunity maintains occult cancer in an equilibrium state.

Authors:  Catherine M Koebel; William Vermi; Jeremy B Swann; Nadeen Zerafa; Scott J Rodig; Lloyd J Old; Mark J Smyth; Robert D Schreiber
Journal:  Nature       Date:  2007-11-18       Impact factor: 49.962

9.  Lung cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with lung cancer mortality in the Atomic Bomb survivors study.

Authors:  G R Howe
Journal:  Radiat Res       Date:  1995-06       Impact factor: 2.841

10.  Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians.

Authors:  John D Mathews; Anna V Forsythe; Zoe Brady; Martin W Butler; Stacy K Goergen; Graham B Byrnes; Graham G Giles; Anthony B Wallace; Philip R Anderson; Tenniel A Guiver; Paul McGale; Timothy M Cain; James G Dowty; Adrian C Bickerstaffe; Sarah C Darby
Journal:  BMJ       Date:  2013-05-21
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