Literature DB >> 24905160

Stem cells go soft: pliant substrate surfaces enhance motor neuron differentiation.

Ning Wang1.   

Abstract

Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24905160      PMCID： PMC4109975          DOI： 10.1016/j.stem.2014.05.007

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

1.  Matrix elasticity directs stem cell lineage specification.

Authors:  Adam J Engler; Shamik Sen; H Lee Sweeney; Dennis E Discher
Journal:  Cell       Date:  2006-08-25       Impact factor: 41.582

2.  Mechanical regulation of cell function with geometrically modulated elastomeric substrates.

Authors:  Jianping Fu; Yang-Kao Wang; Michael T Yang; Ravi A Desai; Xiang Yu; Zhijun Liu; Christopher S Chen
Journal:  Nat Methods       Date:  2010-08-01       Impact factor: 28.547

3.  High-efficiency motor neuron differentiation from human pluripotent stem cells and the function of Islet-1.

Authors:  Qiuhao Qu; Dong Li; Kathleen R Louis; Xiangzhen Li; Hong Yang; Qinyu Sun; Shane R Crandall; Stephanie Tsang; Jiaxi Zhou; Charles L Cox; Jianjun Cheng; Fei Wang
Journal:  Nat Commun       Date:  2014-03-13       Impact factor: 14.919

4.  Role of YAP/TAZ in mechanotransduction.

Authors:  Sirio Dupont; Leonardo Morsut; Mariaceleste Aragona; Elena Enzo; Stefano Giulitti; Michelangelo Cordenonsi; Francesca Zanconato; Jimmy Le Digabel; Mattia Forcato; Silvio Bicciato; Nicola Elvassore; Stefano Piccolo
Journal:  Nature       Date:  2011-06-08       Impact factor: 49.962

5.  Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes.

Authors:  Mark E Hester; Matthew J Murtha; SungWon Song; Meghan Rao; Carlos J Miranda; Kathrin Meyer; Jinbin Tian; Gabriella Boulting; David V Schaffer; Michael X Zhu; Samuel L Pfaff; Fred H Gage; Brian K Kaspar
Journal:  Mol Ther       Date:  2011-07-19       Impact factor: 11.454

6.  TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.

Authors:  Xaralabos Varelas; Rui Sakuma; Payman Samavarchi-Tehrani; Raheem Peerani; Balaji M Rao; Joanna Dembowy; Michael B Yaffe; Peter W Zandstra; Jeffrey L Wrana
Journal:  Nat Cell Biol       Date:  2008-06-22       Impact factor: 28.824

Review 7.  Growth factors, matrices, and forces combine and control stem cells.

Authors:  Dennis E Discher; David J Mooney; Peter W Zandstra
Journal:  Science       Date:  2009-06-26       Impact factor: 47.728

8.  Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells.

Authors:  Farhan Chowdhury; Sungsoo Na; Dong Li; Yeh-Chuin Poh; Tetsuya S Tanaka; Fei Wang; Ning Wang
Journal:  Nat Mater       Date:  2009-10-18       Impact factor: 43.841

9.  Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells.

Authors:  Yubing Sun; Koh Meng Aw Yong; Luis G Villa-Diaz; Xiaoli Zhang; Weiqiang Chen; Renee Philson; Shinuo Weng; Haoxing Xu; Paul H Krebsbach; Jianping Fu
Journal:  Nat Mater       Date:  2014-04-13       Impact factor: 43.841

10.  Generation of organized germ layers from a single mouse embryonic stem cell.

Authors:  Yeh-Chuin Poh; Junwei Chen; Ying Hong; Haiying Yi; Shuang Zhang; Junjian Chen; Douglas C Wu; Lili Wang; Qiong Jia; Rishi Singh; Wenting Yao; Youhua Tan; Arash Tajik; Tetsuya S Tanaka; Ning Wang
Journal:  Nat Commun       Date:  2014-05-30       Impact factor: 14.919
  10 in total
  1 in total

1.  Superparamagnetic Iron Oxide Nanoparticle-Mediated Forces Enhance the Migration of Schwann Cells Across the Astrocyte-Schwann Cell Boundary In vitro.

Authors:  Liangliang Huang; Bing Xia; Zhongyang Liu; Quanliang Cao; Jinghui Huang; Zhuojing Luo
Journal:  Front Cell Neurosci       Date:  2017-03-28       Impact factor: 5.505
  1 in total

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