Literature DB >> 24900708

New Peptide-based antimicrobials for tackling drug resistance in bacteria: single-cell fluorescence imaging.

Jean-Marie Pagès1, Slavka Kascàkovà2, Laure Maigre1, Anas Allam3, Mickael Alimi3, Jacqueline Chevalier1, Erwan Galardon3, Matthieu Réfrégiers2, Isabelle Artaud3.   

Abstract

New peptide molecules with metal binding abilities proved to be active against multidrug resistant clinical isolates. One of them labeled with a dansylated lysine has been imaged inside single-multidrug resistant bacteria cells by deep ultraviolet fluorescence, showing a heterogeneous subcellular localization. The fluorescence intensity is clearly related to the accumulation of the drug inside the bacteria, being dependent both on its concentration and on the incubation time with cells.

Entities:  

Keywords:  Multidrug resistant; amphipatic peptide; fluorescence imaging; metal binding group; microspectrofluorimetry

Year:  2013        PMID： 24900708      PMCID： PMC4027424          DOI： 10.1021/ml400073g

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  13 in total

1.  The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes.

Authors:  Elizabeth Pradel; Jean-Marie Pagès
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

2.  The pharmacophore of short cationic antibacterial peptides.

Authors:  Morten B Strøm; Bengt Erik Haug; Merete L Skar; Wenche Stensen; Trine Stiberg; John S Svendsen
Journal:  J Med Chem       Date:  2003-04-24       Impact factor: 7.446

3.  Synchrotron UV fluorescence microscopy uncovers new probes in cells and tissues.

Authors:  Frederic Jamme; Sandrine Villette; Alexandre Giuliani; Valerie Rouam; Frank Wien; Bruno Lagarde; Matthieu Réfrégiers
Journal:  Microsc Microanal       Date:  2010-08-25       Impact factor: 4.127

Review 4.  Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold.

Authors:  Brandon Findlay; George G Zhanel; Frank Schweizer
Journal:  Antimicrob Agents Chemother       Date:  2010-08-09       Impact factor: 5.191

5.  Inducement and reversal of tetracycline resistance in Escherichia coli K-12 and expression of proton gradient-dependent multidrug efflux pump genes.

Authors:  Miguel Viveiros; Ana Jesus; Mafalda Brito; Clara Leandro; Marta Martins; Diane Ordway; Ana Maria Molnar; Joseph Molnar; Leonard Amaral
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

6.  Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement.

Authors:  Ian Chopra; Christopher Schofield; Martin Everett; Alex O'Neill; Keith Miller; Mark Wilcox; Jean-Marie Frère; Mike Dawson; Lloyd Czaplewski; Uros Urleb; Patrice Courvalin
Journal:  Lancet Infect Dis       Date:  2008-02       Impact factor: 25.071

Review 7.  The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria.

Authors:  Jean-Marie Pagès; Chloë E James; Mathias Winterhalter
Journal:  Nat Rev Microbiol       Date:  2008-11-10       Impact factor: 60.633

Review 8.  Coordination chemistry of bacterial metal transport and sensing.

Authors:  Zhen Ma; Faith E Jacobsen; David P Giedroc
Journal:  Chem Rev       Date:  2009-10       Impact factor: 60.622

Review 9.  Describing the mechanism of antimicrobial peptide action with the interfacial activity model.

Authors:  William C Wimley
Journal:  ACS Chem Biol       Date:  2010-10-15       Impact factor: 5.100

10.  Antibiotic transport in resistant bacteria: synchrotron UV fluorescence microscopy to determine antibiotic accumulation with single cell resolution.

Authors:  Slávka Kaščáková; Laure Maigre; Jacqueline Chevalier; Matthieu Réfrégiers; Jean-Marie Pagès
Journal:  PLoS One       Date:  2012-06-12       Impact factor: 3.240
View more
  3 in total

1.  Spectrofluorimetric quantification of antibiotic drug concentration in bacterial cells for the characterization of translocation across bacterial membranes.

Authors:  Julia Vergalli; Estelle Dumont; Jelena Pajović; Bertrand Cinquin; Laure Maigre; Muriel Masi; Matthieu Réfrégiers; Jean-Marie Pagés
Journal:  Nat Protoc       Date:  2018-05-17       Impact factor: 13.491

2.  Optical Biosensing of Bacteria and Bacterial Communities.

Authors:  Jiayun Hu; Paul W Bohn
Journal:  J Anal Test       Date:  2017-02-06

3.  Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux.

Authors:  M Rhia L Stone; Muriel Masi; Wanida Phetsang; Jean-Marie Pagès; Matthew A Cooper; Mark A T Blaskovich
Journal:  Medchemcomm       Date:  2019-05-17       Impact factor: 3.597
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.