Literature DB >> 24900665

Drug discovery in an academic setting: playing to the strengths.

Donna M Huryn1.   

Abstract

Drug discovery and medicinal chemistry initiatives in academia provide an opportunity to create a unique environment that is distinct from the traditional industrial model. Two characteristics of a university setting that are not usually associated with pharma are the ability to pursue high-risk projects and a depth of expertise, infrastructure, and capabilities in focused areas. Encouraging, supporting, and fostering drug discovery efforts that take advantage of these and other distinguishing characteristics of an academic setting can lead to novel and innovative therapies that might not be discovered otherwise.

Year:  2013        PMID: 24900665      PMCID: PMC4027497          DOI: 10.1021/ml400012g

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN: 1948-5875            Impact factor:   4.345


  5 in total

1.  US academic drug discovery.

Authors:  Stephen Frye; Marina Crosby; Teresa Edwards; Rudolph Juliano
Journal:  Nat Rev Drug Discov       Date:  2011-06       Impact factor: 84.694

2.  Observations on screening-based research and some concerning trends in the literature.

Authors:  Jonathan B Baell
Journal:  Future Med Chem       Date:  2010-10       Impact factor: 3.808

3.  Challenges for academic drug discovery.

Authors:  William L Jorgensen
Journal:  Angew Chem Int Ed Engl       Date:  2012-10-24       Impact factor: 15.336

4.  Future horizons in drug discovery research.

Authors:  Allen B Reitz
Journal:  ACS Med Chem Lett       Date:  2012-01-20       Impact factor: 4.345

5.  Growing PAINS in academic drug discovery.

Authors:  Adrian Whitty
Journal:  Future Med Chem       Date:  2011-05       Impact factor: 3.808

  5 in total
  7 in total

1.  A Medicinal Chemist's Perspective on Transitioning from Industry to Academic Drug Discovery.

Authors:  James C Barrow
Journal:  ACS Med Chem Lett       Date:  2019-04-15       Impact factor: 4.345

Review 2.  Mitigating risk in academic preclinical drug discovery.

Authors:  Jayme L Dahlin; James Inglese; Michael A Walters
Journal:  Nat Rev Drug Discov       Date:  2015-04       Impact factor: 84.694

3.  Consortia's critical role in developing medical countermeasures for re-emerging viral infections: a USA perspective.

Authors:  Maaike Everts; Mark J Suto; George R Painter; Richard J Whitley
Journal:  Future Virol       Date:  2016-02-29       Impact factor: 1.831

4.  The Resurrection of Phenotypic Drug Discovery.

Authors:  Wayne E Childers; Khaled M Elokely; Magid Abou-Gharbia
Journal:  ACS Med Chem Lett       Date:  2020-03-06       Impact factor: 4.345

Review 5.  Contributions of academic laboratories to the discovery and development of chemical biology tools.

Authors:  Donna M Huryn; Lynn O Resnick; Peter Wipf
Journal:  J Med Chem       Date:  2013-05-31       Impact factor: 7.446

6.  Academic medical product development: an emerging alliance of technology transfer organizations and the CTSA.

Authors:  Lynn M Rose; Maaike Everts; Caren Heller; Christine Burke; Nathaniel Hafer; Scott Steele
Journal:  Clin Transl Sci       Date:  2014-06-19       Impact factor: 4.689

7.  The Current Status of Drug Discovery and Development as Originated in United States Academia: The Influence of Industrial and Academic Collaboration on Drug Discovery and Development.

Authors:  Tohru Takebe; Ryoka Imai; Shunsuke Ono
Journal:  Clin Transl Sci       Date:  2018-07-30       Impact factor: 4.689

  7 in total

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