Literature DB >> 24900652

The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions.

B Barry Touré1, Karen Miller-Moslin1, Naeem Yusuff1, Lawrence Perez1, Michael Doré1, Carol Joud1, Walter Michael1, Lucian DiPietro1, Simon van der Plas1, Michael McEwan1, Francois Lenoir1, Madelene Hoe1, Rajesh Karki1, Clayton Springer1, John Sullivan1, Kymberly Levine1, Catherine Fiorilla1, Xiaoling Xie1, Raviraj Kulathila1, Kara Herlihy1, Dale Porter1, Michael Visser1.   

Abstract

Overexpression of the antiapoptotic members of the Bcl-2 family of proteins is commonly associated with cancer cell survival and resistance to chemotherapeutics. Here, we describe the structure-based optimization of a series of N-heteroaryl sulfonamides that demonstrate potent mechanism-based cell death. The role of the acidic nature of the sulfonamide moiety as it relates to potency, solubility, and clearance is examined. This has led to the discovery of novel heterocyclic replacements for the acylsulfonamide core of ABT-737 and ABT-263.

Entities:  

Keywords:  B cell lymphoma; Bcl-2 family; apoptosis; cancer; protein−protein interaction

Year:  2013        PMID： 24900652      PMCID： PMC4027142          DOI： 10.1021/ml300321d

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


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