Literature DB >> 21344906

Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry.

Minoru Ishikawa1, Yuichi Hashimoto.   

Abstract

Mesh：

Substances：

Year:  2011        PMID： 21344906     DOI： 10.1021/jm101356p

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


× No keyword cloud information.
  88 in total

Review 1.  Improving the prediction of the brain disposition for orally administered drugs using BDDCS.

Authors:  Fabio Broccatelli; Caroline A Larregieu; Gabriele Cruciani; Tudor I Oprea; Leslie Z Benet
Journal:  Adv Drug Deliv Rev       Date:  2011-12-21       Impact factor: 15.470

Review 2.  The influence of the 'organizational factor' on compound quality in drug discovery.

Authors:  Paul D Leeson; Stephen A St-Gallay
Journal:  Nat Rev Drug Discov       Date:  2011-09-30       Impact factor: 84.694

3.  Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors.

Authors:  Yingjun Li; Kalyan Kumar Pasunooti; Hanjing Peng; Ruo-Jing Li; Wei Q Shi; Wukun Liu; Zhiqiang Cheng; Sarah A Head; Jun O Liu
Journal:  ACS Med Chem Lett       Date:  2020-04-08       Impact factor: 4.345

4.  Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development.

Authors:  Kelly A Bachovchin; Amrita Sharma; Seema Bag; Dana M Klug; Katherine M Schneider; Baljinder Singh; Hitesh B Jalani; Melissa J Buskes; Naimee Mehta; Scott Tanghe; Jeremiah D Momper; Richard J Sciotti; Ana Rodriguez; Kojo Mensa-Wilmot; Michael P Pollastri; Lori Ferrins
Journal:  J Med Chem       Date:  2019-01-10       Impact factor: 7.446

5.  Spirocyclic and Bicyclic 8-Nitrobenzothiazinones for Tuberculosis with Improved Physicochemical and Pharmacokinetic Properties.

Authors:  Gang Zhang; Michael Howe; Courtney C Aldrich
Journal:  ACS Med Chem Lett       Date:  2019-02-23       Impact factor: 4.345

6.  Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.

Authors:  Na Liu; Bingjie Qin; Lian-Qi Sun; Fei Yu; Lu Lu; Shibo Jiang; Kuo-Hsiung Lee; Lan Xie
Journal:  Bioorg Med Chem Lett       Date:  2014-07-11       Impact factor: 2.823

7.  An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility.

Authors:  Erin M Skoda; Joshua R Sacher; Mustafa Z Kazancioglu; Jaideep Saha; Peter Wipf
Journal:  ACS Med Chem Lett       Date:  2014-06-27       Impact factor: 4.345

8.  3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction.

Authors:  Revital Yefidoff-Freedman; Ting Chen; Rupam Sahoo; Limo Chen; Gerhard Wagner; Jose A Halperin; Bertal H Aktas; Michael Chorev
Journal:  Chembiochem       Date:  2014-01-23       Impact factor: 3.164

9.  Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents.

Authors:  Haijun Chen; Zhengduo Yang; Chunyong Ding; Lili Chu; Yusong Zhang; Kristin Terry; Huiling Liu; Qiang Shen; Jia Zhou
Journal:  ACS Med Chem Lett       Date:  2013-01-15       Impact factor: 4.345

10.  Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility.

Authors:  Stephen S Scully; Alicia J Tang; Morten Lundh; Carrie M Mosher; Kedar M Perkins; Bridget K Wagner
Journal:  J Med Chem       Date:  2013-05-13       Impact factor: 7.446
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.