Literature DB >> 24900571

Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation.

Johan D Oslob1, Russell J Johnson1, Haiying Cai1, Shirley Q Feng1, Lily Hu1, Yuko Kosaka1, Julie Lai1, Mohanram Sivaraja1, Samnang Tep1, Hanbiao Yang1, Cristiana A Zaharia1, Marc J Evanchik1, Robert S McDowell1.   

Abstract

Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochemical activities. The most potent analogue (compound 19) also inhibits rat FASN and inhibits de novo palmitate synthesis in vitro (cell-based) as well as in vivo.

Entities:  

Keywords:  FASN; HCV; antiviral; in vivo; inhibitor; reversible; structure−activity relationship; target modulation

Year:  2012        PMID： 24900571      PMCID： PMC4027139          DOI： 10.1021/ml300335r

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


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