Literature DB >> 21848318

Assessing atropisomer axial chirality in drug discovery and development.

Steven R Laplante1, Lee D Fader, Keith R Fandrick, Daniel R Fandrick, Oliver Hucke, Ray Kemper, Stephen P F Miller, Paul J Edwards.   

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Year:  2011        PMID： 21848318     DOI： 10.1021/jm200584g

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  63 in total

1.  Leveraging Atropisomerism to Obtain a Selective Inhibitor of RET Kinase with Secondary Activities toward EGFR Mutants.

Authors:  Sean T Toenjes; Valeria Garcia; Sean M Maddox; Gregory A Dawson; Maria A Ortiz; F Javier Piedrafita; Jeffrey L Gustafson
Journal:  ACS Chem Biol       Date:  2019-08-29       Impact factor: 5.100

2.  Symmetry in Cascade Chirality-Transfer Processes: A Catalytic Atroposelective Direct Arylation Approach to BINOL Derivatives.

Authors:  Jin-Zheng Wang; Jin Zhou; Chang Xu; Hongbin Sun; László Kürti; Qing-Long Xu
Journal:  J Am Chem Soc       Date:  2016-04-14       Impact factor: 15.419

3.  Towards a Catalytic Atroposelective Synthesis of Diaryl Ethers via C(sp 2)-H Alkylation Using Nitroalkanes.

Authors:  Andrew N Dinh; Ryan R Noorbehesht; Sean T Toenjes; Amy C Jackson; Mirza A Saputra; Sean M Maddox; Jeffrey L Gustafson
Journal:  Synlett       Date:  2018-07-31       Impact factor: 2.454

4.  Illuminating the dark conformational space of macrocycles using dominant rotors.

Authors:  Diego B Diaz; Solomon D Appavoo; Anastasia F Bogdanchikova; Yury Lebedev; Timothy J McTiernan; Gabriel Dos Passos Gomes; Andrei K Yudin
Journal:  Nat Chem       Date:  2021-02-15       Impact factor: 24.427

5.  Measurement of atropisomer racemization kinetics using segmented flow technology.

Authors:  Jennifer E Davoren; Mark W Bundesmann; Qi T Yan; Elizabeth M Collantes; Scot Mente; Deane M Nason; David L Gray
Journal:  ACS Med Chem Lett       Date:  2012-03-12       Impact factor: 4.345

6.  Regioselective derivatizations of a tribrominated atropisomeric benzamide scaffold.

Authors:  Kimberly T Barrett; Scott J Miller
Journal:  Org Lett       Date:  2015-01-12       Impact factor: 6.005

7.  Global Substance Registration System: consistent scientific descriptions for substances related to health.

Authors:  Tyler Peryea; Noel Southall; Mitch Miller; Daniel Katzel; Niko Anderson; Jorge Neyra; Sarah Stemann; Ðắc-Trung Nguyễn; Dammika Amugoda; Archana Newatia; Ramez Ghazzaoui; Elaine Johanson; Herman Diederik; Larry Callahan; Frank Switzer
Journal:  Nucleic Acids Res       Date:  2021-01-08       Impact factor: 16.971

Review 8.  Atropisomerism in medicinal chemistry: challenges and opportunities.

Authors:  Sean T Toenjes; Jeffrey L Gustafson
Journal:  Future Med Chem       Date:  2018-01-30       Impact factor: 3.808

9.  Rotational isomers of N-methyl-N-arylacetamides and their derived enolates: implications for asymmetric Hartwig oxindole cyclizations.

Authors:  Jérémie Mandel; Xiaohong Pan; E Ben Hay; Steven J Geib; Craig S Wilcox; Dennis P Curran
Journal:  J Org Chem       Date:  2013-04-09       Impact factor: 4.354

10.  Practical Organocatalytic Synthesis of Functionalized Non-C2-Symmetrical Atropisomeric Biaryls.

Authors:  Hongyin Gao; Qing-Long Xu; Craig Keene; Muhammed Yousufuddin; Daniel H Ess; László Kürti
Journal:  Angew Chem Int Ed Engl       Date:  2015-11-23       Impact factor: 15.336
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