Literature DB >> 19637174

The challenge of atropisomerism in drug discovery.

Jonathan Clayden1, Wesley J Moran, Paul J Edwards, Steven R LaPlante.   

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Year:  2009        PMID： 19637174     DOI： 10.1002/anie.200901719

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  64 in total

1.  Electronically Rich N-Substituted Tetrahydroisoquinoline 3-Carboxylic Acid Esters: Concise Synthesis and Conformational Studies.

Authors:  Rami A Al-Horani; Umesh R Desai
Journal:  Tetrahedron       Date:  2012-01-10       Impact factor: 2.457

2.  Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.

Authors:  Kristin Jansen Labby; Fengtian Xue; James M Kraus; Haitao Ji; Jan Mataka; Huiying Li; Pavel Martásek; Linda J Roman; Thomas L Poulos; Richard B Silverman
Journal:  Bioorg Med Chem       Date:  2012-02-07       Impact factor: 3.641

3.  Dynamic kinetic resolution of biaryl atropisomers via peptide-catalyzed asymmetric bromination.

Authors:  Jeffrey L Gustafson; Daniel Lim; Scott J Miller
Journal:  Science       Date:  2010-06-04       Impact factor: 47.728

4.  Asymmetric total synthesis of the epoxykinamycin FL-120 B'.

Authors:  Stephen S Scully; John A Porco
Journal:  Angew Chem Int Ed Engl       Date:  2011-08-30       Impact factor: 15.336

5.  Leveraging Atropisomerism to Obtain a Selective Inhibitor of RET Kinase with Secondary Activities toward EGFR Mutants.

Authors:  Sean T Toenjes; Valeria Garcia; Sean M Maddox; Gregory A Dawson; Maria A Ortiz; F Javier Piedrafita; Jeffrey L Gustafson
Journal:  ACS Chem Biol       Date:  2019-08-29       Impact factor: 5.100

6.  Effects of rigidity on the selectivity of protein kinase inhibitors.

Authors:  Amir Assadieskandar; Caiqun Yu; Pierre Maisonneuve; Xu Liu; Ying-Chu Chen; G K Surya Prakash; Igor Kurinov; Frank Sicheri; Chao Zhang
Journal:  Eur J Med Chem       Date:  2018-01-31       Impact factor: 6.514

7.  Symmetry in Cascade Chirality-Transfer Processes: A Catalytic Atroposelective Direct Arylation Approach to BINOL Derivatives.

Authors:  Jin-Zheng Wang; Jin Zhou; Chang Xu; Hongbin Sun; László Kürti; Qing-Long Xu
Journal:  J Am Chem Soc       Date:  2016-04-14       Impact factor: 15.419

8.  Towards a Catalytic Atroposelective Synthesis of Diaryl Ethers via C(sp 2)-H Alkylation Using Nitroalkanes.

Authors:  Andrew N Dinh; Ryan R Noorbehesht; Sean T Toenjes; Amy C Jackson; Mirza A Saputra; Sean M Maddox; Jeffrey L Gustafson
Journal:  Synlett       Date:  2018-07-31       Impact factor: 2.454

9.  A Stereodynamic Redox-Interconversion Network of Vicinal Tertiary and Quaternary Carbon Stereocenters in Hydroquinone-Quinone Hybrid Dihydrobenzofurans.

Authors:  Golo Storch; Byoungmoo Kim; Brandon Q Mercado; Scott J Miller
Journal:  Angew Chem Int Ed Engl       Date:  2018-10-18       Impact factor: 15.336

10.  Measurement of atropisomer racemization kinetics using segmented flow technology.

Authors:  Jennifer E Davoren; Mark W Bundesmann; Qi T Yan; Elizabeth M Collantes; Scot Mente; Deane M Nason; David L Gray
Journal:  ACS Med Chem Lett       Date:  2012-03-12       Impact factor: 4.345
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