Literature DB >> 24900492

Drug repurposing and the medicinal chemist.

Jeffrey Aubé1.   

Abstract

Drug repurposing is an approach to finding new uses for older drugs and has been gaining popularity in recent years. The role of traditional medicinal chemistry in the context of these efforts is considered.

Year:  2012        PMID： 24900492      PMCID： PMC4025634          DOI： 10.1021/ml300114c

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  6 in total

Review 1.  Drug repositioning: identifying and developing new uses for existing drugs.

Authors:  Ted T Ashburn; Karl B Thor
Journal:  Nat Rev Drug Discov       Date:  2004-08       Impact factor: 84.694

Review 2.  Finding new tricks for old drugs: an efficient route for public-sector drug discovery.

Authors:  Kerry A O'Connor; Bryan L Roth
Journal:  Nat Rev Drug Discov       Date:  2005-12       Impact factor: 84.694

Review 3.  Application of combinatorial chemistry science on modern drug discovery.

Authors:  J Phillip Kennedy; Lyndsey Williams; Thomas M Bridges; R Nathan Daniels; David Weaver; Craig W Lindsley
Journal:  J Comb Chem       Date:  2008-01-26

4.  Mining for therapeutic gold.

Authors:  Francis S Collins
Journal:  Nat Rev Drug Discov       Date:  2011-06       Impact factor: 84.694

5.  Drug Repurposing from an Academic Perspective.

Authors:  Tudor I Oprea; Julie E Bauman; Cristian G Bologa; Tione Buranda; Alexandre Chigaev; Bruce S Edwards; Jonathan W Jarvik; Hattie D Gresham; Mark K Haynes; Brian Hjelle; Robert Hromas; Laurie Hudson; Debra A Mackenzie; Carolyn Y Muller; John C Reed; Peter C Simons; Yelena Smagley; Juan Strouse; Zurab Surviladze; Todd Thompson; Oleg Ursu; Anna Waller; Angela Wandinger-Ness; Stuart S Winter; Yang Wu; Susan M Young; Richard S Larson; Cheryl Willman; Larry A Sklar
Journal:  Drug Discov Today Ther Strateg       Date:  2011

6.  The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics.

Authors:  Ruili Huang; Noel Southall; Yuhong Wang; Adam Yasgar; Paul Shinn; Ajit Jadhav; Dac-Trung Nguyen; Christopher P Austin
Journal:  Sci Transl Med       Date:  2011-04-27       Impact factor: 17.956
  6 in total
  13 in total

Review 1.  Effect of Metformin and Statin Use on Survival in Pancreatic Cancer Patients: a Systematic Literature Review and Meta-analysis.

Authors:  Judith M Graber; Shou-En Lu; Yong Lin; Grace Lu-Yao; Xiang-Lin Tan
Journal:  Curr Med Chem       Date:  2018       Impact factor: 4.530

2.  Screening-based translation of public research encounters painful problems.

Authors:  Jonathan B Baell
Journal:  ACS Med Chem Lett       Date:  2015-02-09       Impact factor: 4.345

Review 3.  Shifting from the single to the multitarget paradigm in drug discovery.

Authors:  José L Medina-Franco; Marc A Giulianotti; Gregory S Welmaker; Richard A Houghten
Journal:  Drug Discov Today       Date:  2013-01-20       Impact factor: 7.851

4.  Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.

Authors:  Jessamyn I Perlmutter; Lauren T Forbes; Damian J Krysan; Katherine Ebsworth-Mojica; Jennifer M Colquhoun; Jenna L Wang; Paul M Dunman; Daniel P Flaherty
Journal:  J Med Chem       Date:  2014-10-06       Impact factor: 7.446

5.  Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction.

Authors:  Tanja Štular; Samo Lešnik; Kaja Rožman; Julia Schink; Mitja Zdouc; An Ghysels; Feng Liu; Courtney C Aldrich; V Joachim Haupt; Sebastian Salentin; Simone Daminelli; Michael Schroeder; Thierry Langer; Stanislav Gobec; Dušanka Janežič; Janez Konc
Journal:  J Med Chem       Date:  2016-12-12       Impact factor: 7.446

6.  Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.

Authors:  Bryan T Mott; Ran He; Xiaochun Chen; Jennifer M Fox; Curt I Civin; Ravit Arav-Boger; Gary H Posner
Journal:  Bioorg Med Chem       Date:  2013-04-22       Impact factor: 3.641

Review 7.  Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art.

Authors:  Rebecca L Charlton; Bartira Rossi-Bergmann; Paul W Denny; Patrick G Steel
Journal:  Parasitology       Date:  2017-08-14       Impact factor: 3.234

Review 8.  Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects.

Authors:  Stephen Patterson; Susan Wyllie
Journal:  Trends Parasitol       Date:  2014-04-26

9.  The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis.

Authors:  Stephen Patterson; Susan Wyllie; Suzanne Norval; Laste Stojanovski; Frederick Rc Simeons; Jennifer L Auer; Maria Osuna-Cabello; Kevin D Read; Alan H Fairlamb
Journal:  Elife       Date:  2016-05-24       Impact factor: 8.140

10.  Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Salmonella enterica Serovar Typhi.

Authors:  Shama Mujawar; Derek Gatherer; Chandrajit Lahiri
Journal:  Front Cell Infect Microbiol       Date:  2018-11-14       Impact factor: 5.293
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