Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Mining for therapeutic gold.

Literature DB >> 21629277

Mining for therapeutic gold.

Abstract

A comprehensive and collaborative strategy to enable the investigation of new uses of approved and abandoned drug compounds could advance translational research.

Mesh：

Substances：

Year: 2011 PMID： 21629277 PMCID： PMC5101935 DOI： 10.1038/nrd3461

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

2 in total

Review 1. How to improve R&D productivity: the pharmaceutical industry's grand challenge.

Authors: Steven M Paul; Daniel S Mytelka; Christopher T Dunwiddie; Charles C Persinger; Bernard H Munos; Stacy R Lindborg; Aaron L Schacht
Journal: Nat Rev Drug Discov Date: 2010-02-19 Impact factor: 84.694

2. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics.

Authors: Ruili Huang; Noel Southall; Yuhong Wang; Adam Yasgar; Paul Shinn; Ajit Jadhav; Dac-Trung Nguyen; Christopher P Austin
Journal: Sci Transl Med Date: 2011-04-27 Impact factor: 17.956

2 in total

36 in total

Review 1. Pioneering government-sponsored drug repositioning collaborations: progress and learning.

Authors: Donald E Frail; Madeleine Brady; K Jane Escott; Alison Holt; Hitesh J Sanganee; Menelas N Pangalos; Chris Watkins; Craig D Wegner
Journal: Nat Rev Drug Discov Date: 2015-11-20 Impact factor: 84.694

2. Innovation in therapeutics development at the NCATS.

Authors: Christine M Colvis; Christopher P Austin
Journal: Neuropsychopharmacology Date: 2014-01 Impact factor: 7.853

3. Reengineering translational science: the time is right.

Authors: Francis S Collins
Journal: Sci Transl Med Date: 2011-07-06 Impact factor: 17.956

4. Drug Repurposing from an Academic Perspective.

Authors: Tudor I Oprea; Julie E Bauman; Cristian G Bologa; Tione Buranda; Alexandre Chigaev; Bruce S Edwards; Jonathan W Jarvik; Hattie D Gresham; Mark K Haynes; Brian Hjelle; Robert Hromas; Laurie Hudson; Debra A Mackenzie; Carolyn Y Muller; John C Reed; Peter C Simons; Yelena Smagley; Juan Strouse; Zurab Surviladze; Todd Thompson; Oleg Ursu; Anna Waller; Angela Wandinger-Ness; Stuart S Winter; Yang Wu; Susan M Young; Richard S Larson; Cheryl Willman; Larry A Sklar
Journal: Drug Discov Today Ther Strateg Date: 2011

5. Drug repurposing: far beyond new targets for old drugs.

Authors: T I Oprea; J Mestres
Journal: AAPS J Date: 2012-07-24 Impact factor: 4.009

6. A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C.

Authors: Christopher Koh; Preeti Dubey; Ma Ai Thanda Han; Peter J Walter; H Martin Garraffo; Pallavi Surana; Noel T Southall; Nathaniel Borochov; Susan L Uprichard; Scott J Cotler; Ohad Etzion; Theo Heller; Harel Dahari; T Jake Liang
Journal: Antiviral Res Date: 2019-01-31 Impact factor: 5.970

10. Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership.

Authors: Scott J Weir; Louis J DeGennaro; Christopher P Austin
Journal: Cancer Res Date: 2012-01-13 Impact factor: 12.701