Sang-Geon Cho1, Ju Han Kim2, Jae Young Cho2, Hyeon Sik Kim3, Hee-Seung Bom3. 1. Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju, South Korea. 2. Department of Cardiology, Chonnam National University Hospital, Gwangju, South Korea. 3. Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, 322 Seoyang-ro Hwasun-eup, Hwasun-gun, Jeonnam Korea 519-763.
Abstract
PURPOSE: The purpose of this study is to compare the myocardial blood flow (MBF) and flow reserve (MFR) between proximal and mid-to-distal lesions of the left anterior descending artery (pLAD and mdLAD, respectively) using N-13 ammonia positron emission tomography/computed tomography (PET/CT). METHODS: Subjects were 11 patients (six men and five women, mean age 64.5 years) with known coronary artery disease (CAD) involving LAD studied by N-13 ammonia PET/CT. They were divided into two groups by the location of stenotic lesions, i.e. pLAD versus mdLAD. Global and regional MBF and MFR were measured and compared. Characteristics of perfusion defects including the number of involved segments, basal area involvement, location, size, and shape were also compared between the two groups. RESULTS: The regional MFR in mid-anterior segment was significantly lower in pLAD group (1.80 ± 0.35 vs 2.76 ± 1.13 for pLAD and mdLAD groups, respectively, p = 0.034), while global MFR was not different (2.10 ± 1.10 vs 2.34 ± 0.84). Both stress and rest MBF in LAD territories were not different in both groups. The size of the perfusion defects were significantly larger in pLAD group (44.0 ± 11.5 % vs 21.1 ± 15.8 %, p = 0.041). Other characteristics such as location, basal area involvement, and shape were not significantly different between two groups. CONCLUSIONS: The proximal lesion makes lower MFR in the mid-anterior segment and larger perfusion defect in the LAD territory but comparable MBF compared with mdLAD lesion.
PURPOSE: The purpose of this study is to compare the myocardial blood flow (MBF) and flow reserve (MFR) between proximal and mid-to-distal lesions of the left anterior descending artery (pLAD and mdLAD, respectively) using N-13 ammonia positron emission tomography/computed tomography (PET/CT). METHODS: Subjects were 11 patients (six men and five women, mean age 64.5 years) with known coronary artery disease (CAD) involving LAD studied by N-13 ammonia PET/CT. They were divided into two groups by the location of stenotic lesions, i.e. pLAD versus mdLAD. Global and regional MBF and MFR were measured and compared. Characteristics of perfusion defects including the number of involved segments, basal area involvement, location, size, and shape were also compared between the two groups. RESULTS: The regional MFR in mid-anterior segment was significantly lower in pLAD group (1.80 ± 0.35 vs 2.76 ± 1.13 for pLAD and mdLAD groups, respectively, p = 0.034), while global MFR was not different (2.10 ± 1.10 vs 2.34 ± 0.84). Both stress and rest MBF in LAD territories were not different in both groups. The size of the perfusion defects were significantly larger in pLAD group (44.0 ± 11.5 % vs 21.1 ± 15.8 %, p = 0.041). Other characteristics such as location, basal area involvement, and shape were not significantly different between two groups. CONCLUSIONS: The proximal lesion makes lower MFR in the mid-anterior segment and larger perfusion defect in the LAD territory but comparable MBF compared with mdLAD lesion.
Authors: P J Scanlon; D P Faxon; A M Audet; B Carabello; G J Dehmer; K A Eagle; R D Legako; D F Leon; J A Murray; S E Nissen; C J Pepine; R M Watson; J L Ritchie; R J Gibbons; M D Cheitlin; T J Gardner; A Garson; R O Russell; T J Ryan; S C Smith Journal: J Am Coll Cardiol Date: 1999-05 Impact factor: 24.094
Authors: Michael Fiechter; Jelena R Ghadri; Cathérine Gebhard; Tobias A Fuchs; Aju P Pazhenkottil; Rene N Nkoulou; Bernhard A Herzog; Christophe A Wyss; Oliver Gaemperli; Philipp A Kaufmann Journal: J Nucl Med Date: 2012-06-29 Impact factor: 10.057
Authors: George S K Fung; W Paul Segars; Taek-Soo Lee; Takahiro Higuchi; Alexander I Veress; Grant T Gullberg; Benjamin M W Tsui Journal: IEEE Nucl Sci Symp Conf Rec (1997) Date: 2010 Oct-Nov
Authors: J Schwitter; D Nanz; S Kneifel; K Bertschinger; M Büchi; P R Knüsel; B Marincek; T F Lüscher; G K von Schulthess Journal: Circulation Date: 2001-05-08 Impact factor: 29.690
Authors: Leonardo De Luca; Francesco Bovenzi; Domenico Rubini; Artor Niccoli-Asabella; Giuseppe Rubini; Italo De Luca Journal: J Nucl Med Date: 2004-04 Impact factor: 10.057
Authors: Bernhard A Herzog; Lars Husmann; Ines Valenta; Oliver Gaemperli; Patrick T Siegrist; Fabian M Tay; Nina Burkhard; Christophe A Wyss; Philipp A Kaufmann Journal: J Am Coll Cardiol Date: 2009-07-07 Impact factor: 24.094