Hye Ok Kim1, Sun-Young Chae1, Sora Baek1, Dae Hyuk Moon1. 1. Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Pungnap2-dong, Songpa-gu, Seoul, 138-736 Korea.
Abstract
PURPOSE: We evaluated the factors affecting changes in the postoperative glomerular filtration rate (GFR) after unilateral nephrectomy in living kidney donors and patients with renal disease. METHODS: We studied 141 subjects who underwent living donor nephrectomy for renal transplantation (n = 75) or unilateral nephrectomy for renal diseases (n = 66). The GFR of the individual kidney was determined by Tc-99m DTPA scintigraphy before and after nephrectomy. By performing multiple linear regression analysis, we evaluated the factors that are thought to affect changes in GFR, such as age, sex, body mass index (BMI), preoperative GFR, preoperative creatinine level, operated side, presence of diabetes mellitus (DM), presence of hypertension (HTN), and duration of follow-up. RESULTS: In both the donor nephrectomy and the disease nephrectomy groups, GFR increased significantly after nephrectomy (46.9 ± 8.4 to 58.1 ± 12.5 vs. 43.0 ± 9.6 to 48.6 ± 12.8 ml/min, p < 0.05). In the donor nephrectomy group, age was significantly associated with change in GFR (β = -0.3, p < 0.005). In the disease nephrectomy group, HTN, preoperative creatinine level, and age were significantly associated with change in GFR (β = -6.2, p < 0.005; β = -10.9, p < 0.01; β = -0.2, p < 0.01, respectively). This compensatory change in GFR was not significantly related to sex, duration of follow-up, or operated side in either group. CONCLUSIONS: The compensatory change in the GFR of the remaining kidney declined with increasing age in both living kidney donors and patients with renal disease.
PURPOSE: We evaluated the factors affecting changes in the postoperative glomerular filtration rate (GFR) after unilateral nephrectomy in living kidney donors and patients with renal disease. METHODS: We studied 141 subjects who underwent living donor nephrectomy for renal transplantation (n = 75) or unilateral nephrectomy for renal diseases (n = 66). The GFR of the individual kidney was determined by Tc-99m DTPA scintigraphy before and after nephrectomy. By performing multiple linear regression analysis, we evaluated the factors that are thought to affect changes in GFR, such as age, sex, body mass index (BMI), preoperative GFR, preoperative creatinine level, operated side, presence of diabetes mellitus (DM), presence of hypertension (HTN), and duration of follow-up. RESULTS: In both the donor nephrectomy and the disease nephrectomy groups, GFR increased significantly after nephrectomy (46.9 ± 8.4 to 58.1 ± 12.5 vs. 43.0 ± 9.6 to 48.6 ± 12.8 ml/min, p < 0.05). In the donor nephrectomy group, age was significantly associated with change in GFR (β = -0.3, p < 0.005). In the disease nephrectomy group, HTN, preoperative creatinine level, and age were significantly associated with change in GFR (β = -6.2, p < 0.005; β = -10.9, p < 0.01; β = -0.2, p < 0.01, respectively). This compensatory change in GFR was not significantly related to sex, duration of follow-up, or operated side in either group. CONCLUSIONS: The compensatory change in the GFR of the remaining kidney declined with increasing age in both living kidney donors and patients with renal disease.
Authors: Scott R Johnson; Khalid Khwaja; Martha Pavlakis; Anthony P Monaco; Douglas W Hanto Journal: Clin Transplant Date: 2005-10 Impact factor: 2.863
Authors: Anjali Bhatt Saxena; Bryan D Myers; Geraldine Derby; Kristina L Blouch; Jieshi Yan; Bing Ho; Jane C Tan Journal: Am J Physiol Renal Physiol Date: 2006-03-08