OBJECTIVE: We aimed to improve Tc-99m DTPA glomerular filtration rate (GFR) scintigraphy (Gates' method) in a prospective study using Cr-51 EDTA GFR test as a gold standard. METHODS: Fifty-seven Tc-99m DTPA GFR scintigrams in 45 subjects (male/female = 33:12, age = 45.9 ± 17.6 years, 14 healthy volunteers and 31 nephrectomised patients) were compared using Cr-51 EDTA GFR tests. Using the %renal uptake of Tc-99m DTPA and Cr-51 EDTA GFR, a revised equation for GFR was established through linear regression analysis. RESULTS: The revised equation for improved GFR was GFR(mL/min) = (%renal uptake × 11.7773) - 0.7354. Gates' original GFRs (70.1 ± 20.5 mL/min/1.73 m(2)) were significantly lower than Cr-51 EDTA GFRs (97.0 ± 31.9 mL/min/1.73 m(2); P < 0.0001), but the improved GFRs (98.0 ± 26.3 mL/min/1.73 m(2)) were not different from (P = 0.7360) and had a significant correlation with (r = 0.73, P < 0.0001) the Cr-51 EDTA GFRs. The revised GFR equation effectively demonstrated perioperative GFR changes in kidneys that were operated on and the contralateral kidneys at 3 and 6 months post-partial nephrectomy (n = 25). CONCLUSIONS: GFR measurement using Tc-99m DTPA scintigraphy could be significantly improved by a revised equation derived from the comparison with Cr-51 EDTA GFR. KEY POINTS: • Measurement of glomerular filtration rate is difficult following nephrectomy. • Measurements can be significantly improved by new renal sctintigraphic methods. • This helps physicians to measure kidney function of patients following nephrectomy. • Management of renal tumour patients should become more effective.
OBJECTIVE: We aimed to improve Tc-99mDTPA glomerular filtration rate (GFR) scintigraphy (Gates' method) in a prospective study using Cr-51 EDTA GFR test as a gold standard. METHODS: Fifty-seven Tc-99mDTPA GFR scintigrams in 45 subjects (male/female = 33:12, age = 45.9 ± 17.6 years, 14 healthy volunteers and 31 nephrectomised patients) were compared using Cr-51 EDTA GFR tests. Using the %renal uptake of Tc-99mDTPA and Cr-51 EDTA GFR, a revised equation for GFR was established through linear regression analysis. RESULTS: The revised equation for improved GFR was GFR(mL/min) = (%renal uptake × 11.7773) - 0.7354. Gates' original GFRs (70.1 ± 20.5 mL/min/1.73 m(2)) were significantly lower than Cr-51 EDTA GFRs (97.0 ± 31.9 mL/min/1.73 m(2); P < 0.0001), but the improved GFRs (98.0 ± 26.3 mL/min/1.73 m(2)) were not different from (P = 0.7360) and had a significant correlation with (r = 0.73, P < 0.0001) the Cr-51 EDTA GFRs. The revised GFR equation effectively demonstrated perioperative GFR changes in kidneys that were operated on and the contralateral kidneys at 3 and 6 months post-partial nephrectomy (n = 25). CONCLUSIONS: GFR measurement using Tc-99mDTPA scintigraphy could be significantly improved by a revised equation derived from the comparison with Cr-51 EDTA GFR. KEY POINTS: • Measurement of glomerular filtration rate is difficult following nephrectomy. • Measurements can be significantly improved by new renal sctintigraphic methods. • This helps physicians to measure kidney function of patients following nephrectomy. • Management of renal tumourpatients should become more effective.
Authors: M D Blaufox; M Aurell; B Bubeck; E Fommei; A Piepsz; C Russell; A Taylor; H S Thomsen; D Volterrani Journal: J Nucl Med Date: 1996-11 Impact factor: 10.057
Authors: N G De Santo; P Anastasio; M Cirillo; D Santoro; L Spitali; L Mansi; L Celentano; D Capodicasa; E Cirillo; E Del Vecchio; C Pascale; G Capasso Journal: Nephron Date: 1999-02 Impact factor: 2.847
Authors: Gary L Myers; W Greg Miller; Josef Coresh; James Fleming; Neil Greenberg; Tom Greene; Thomas Hostetter; Andrew S Levey; Mauro Panteghini; Michael Welch; John H Eckfeldt Journal: Clin Chem Date: 2005-12-06 Impact factor: 8.327