Literature DB >> 24893728

[Current practice in coagulation and transfusion therapy in multiple trauma patients: A German nation-wide online survey].

A Wafaisade1, H Wyen2, M Mutschler3, S Lendemans4, B Bouillon3, S Flohe5, T Paffrath3, M Maegele3, T Tjardes3, C Probst3.   

Abstract

BACKGROUND: In recent years, the treatment of trauma-associated coagulopathy and bleeding has advanced enormously. The aim of this study was to assess the current practice of coagulation and transfusion management in Germany. PATIENTS AND METHODS: From October 2011 until January 2012 we conducted a survey via online-questionnaire that was sent per E-Mail to all members of the German Society for Trauma Surgery. It comprised 12 questions with respect to current treatment of coagulopathy and haemorrhage in trauma patients.
RESULTS: The response rate was 145/3006 (5 %). The respondents had following specialties: 77.2 % trauma surgery 15.9 % anesthesiology, 6.9 % others. 64 % of respondents were employed by a Level 1 trauma centre, wheras 17 % worked in a local level 3 centre. The majority (94 %) claimed to treat hypothermia regularly. Only about half of the participants reported to follow a massive transfusion protocol in their institution. The potential components of these protocols were reported in varying rates, being it well-established components (e.g. FFP 78 %; Fibrinogen 75 %) or therapies with poor evidence in multiple trauma (Desmopressin 39 %, rFVIIa 47 %). Calcium was provided by only 48 % of respondents although generally recommended in all guidelines.
CONCLUSION: The current study suggests that in Germany strategies and principles regarding management of trauma-associated coagulopathy are standardized only poorly. Level 1 centres appear to apply a more advanced approach, however to much variability exists with respect to the components of the transfusion protocols. The low response rate indicates that most German trauma surgeons consider coagulation and hemorrhage as "expert-topics" beyond their field of duty.

Entities:  

Keywords:  Bleeding; Coagulation; Multiple trauma; Survey; Transfusion

Mesh:

Year:  2015        PMID: 24893728     DOI: 10.1007/s00113-014-2596-1

Source DB:  PubMed          Journal:  Unfallchirurg        ISSN: 0177-5537            Impact factor:   1.000


  25 in total

1.  Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients.

Authors:  Marc Maegele; Rolf Lefering; Nedim Yucel; Thorsten Tjardes; Dieter Rixen; Thomas Paffrath; Christian Simanski; Edmund Neugebauer; Bertil Bouillon
Journal:  Injury       Date:  2007-01-09       Impact factor: 2.586

2.  Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage.

Authors:  Carl J Hauser; Kenneth Boffard; Richard Dutton; Gordon R Bernard; Martin A Croce; John B Holcomb; Ari Leppaniemi; Michael Parr; Jean-Louis Vincent; Bartholomew J Tortella; Jeannett Dimsits; Bertil Bouillon
Journal:  J Trauma       Date:  2010-09

Review 3.  Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations.

Authors:  David S Kauvar; Rolf Lefering; Charles E Wade
Journal:  J Trauma       Date:  2006-06

4.  High plasma to red blood cell ratios are associated with lower mortality rates in patients receiving multiple transfusion (4≤red blood cell units<10) during acute trauma resuscitation.

Authors:  Arasch Wafaisade; Marc Maegele; Rolf Lefering; Maximilian Braun; Sigune Peiniger; Edmund Neugebauer; Bertil Bouillon
Journal:  J Trauma       Date:  2011-01

5.  The impact of fresh frozen plasma vs coagulation factor concentrates on morbidity and mortality in trauma-associated haemorrhage and massive transfusion.

Authors:  Ulrike Nienaber; Petra Innerhofer; Isabella Westermann; Herbert Schöchl; Rene Attal; Robert Breitkopf; Marc Maegele
Journal:  Injury       Date:  2011-03-09       Impact factor: 2.586

6.  Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate.

Authors:  Herbert Schöchl; Ulrike Nienaber; Georg Hofer; Wolfgang Voelckel; Csilla Jambor; Gisela Scharbert; Sibylle Kozek-Langenecker; Cristina Solomon
Journal:  Crit Care       Date:  2010-04-07       Impact factor: 9.097

Review 7.  Management of bleeding and coagulopathy following major trauma: an updated European guideline.

Authors:  Donat R Spahn; Bertil Bouillon; Vladimir Cerny; Timothy J Coats; Jacques Duranteau; Enrique Fernández-Mondéjar; Daniela Filipescu; Beverley J Hunt; Radko Komadina; Giuseppe Nardi; Edmund Neugebauer; Yves Ozier; Louis Riddez; Arthur Schultz; Jean-Louis Vincent; Rolf Rossaint
Journal:  Crit Care       Date:  2013-04-19       Impact factor: 9.097

8.  The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital.

Authors:  Matthew A Borgman; Philip C Spinella; Jeremy G Perkins; Kurt W Grathwohl; Thomas Repine; Alec C Beekley; James Sebesta; Donald Jenkins; Charles E Wade; John B Holcomb
Journal:  J Trauma       Date:  2007-10

9.  The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital.

Authors:  Harry K Stinger; Philip C Spinella; Jeremy G Perkins; Kurt W Grathwohl; Jose Salinas; Wenjun Z Martini; John R Hess; Michael A Dubick; Clayton D Simon; Alec C Beekley; Steven E Wolf; Charles E Wade; John B Holcomb
Journal:  J Trauma       Date:  2008-02

10.  The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks.

Authors:  John B Holcomb; Deborah J del Junco; Erin E Fox; Charles E Wade; Mitchell J Cohen; Martin A Schreiber; Louis H Alarcon; Yu Bai; Karen J Brasel; Eileen M Bulger; Bryan A Cotton; Nena Matijevic; Peter Muskat; John G Myers; Herb A Phelan; Christopher E White; Jiajie Zhang; Mohammad H Rahbar
Journal:  JAMA Surg       Date:  2013-02       Impact factor: 14.766

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  7 in total

1.  Infrastructure and clinical practice for the detection and management of trauma-associated haemorrhage and coagulopathy.

Authors:  A Driessen; N Schäfer; V Albrecht; M Schenk; M Fröhlich; E K Stürmer; M Maegele
Journal:  Eur J Trauma Emerg Surg       Date:  2014-10-25       Impact factor: 3.693

2.  The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition.

Authors:  Donat R Spahn; Bertil Bouillon; Vladimir Cerny; Jacques Duranteau; Daniela Filipescu; Beverley J Hunt; Radko Komadina; Marc Maegele; Giuseppe Nardi; Louis Riddez; Charles-Marc Samama; Jean-Louis Vincent; Rolf Rossaint
Journal:  Crit Care       Date:  2019-03-27       Impact factor: 9.097

3.  Practice management of acute trauma haemorrhage and haemostatic disorders across German trauma centres.

Authors:  V Albrecht; N Schäfer; E K Stürmer; A Driessen; L Betsche; M Schenk; M Maegele
Journal:  Eur J Trauma Emerg Surg       Date:  2015-11-30       Impact factor: 3.693

Review 4.  [Hemoglobin-oriented and coagulation factor-based algorithm : Effect on transfusion needs and standardized mortality rate in massively transfused trauma patients].

Authors:  P Hilbert-Carius; G Hofmann; R Stuttmann
Journal:  Anaesthesist       Date:  2015-10-09       Impact factor: 1.041

5.  Diversity in clinical management and protocols for the treatment of major bleeding trauma patients across European level I Trauma Centres.

Authors:  Nadine Schäfer; Arne Driessen; Matthias Fröhlich; Ewa K Stürmer; Marc Maegele
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2015-10-01       Impact factor: 2.953

6.  Effect and clinical value of coagulation test on adverse reactions of blood transfusion in patients with major bleeding in ectopic pregnancy.

Authors:  Fanjiu Kong; Yingbo Li; Xiaoxin Liu
Journal:  Exp Ther Med       Date:  2018-09-27       Impact factor: 2.447

7.  Terrorist incidents: strategic treatment objectives, tactical diagnostic procedures and the estimated need of blood and clotting products.

Authors:  Axel Franke; Dan Bieler; Benedikt Friemert; Patrick Hoth; Hans-Christoph Pape; Gerhard Achatz
Journal:  Eur J Trauma Emerg Surg       Date:  2020-07-16       Impact factor: 3.693

  7 in total

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