PURPOSE: The objective of this study is to compare the chromosomal distribution of early miscarriages with or without embryonic poles. MATERIALS AND METHODS: It was a retrospective study of 223 women who underwent dilation and curettage (D&C) between 1995 and 2013 for early miscarriages. The presence or absence of a fetal pole was evaluated by abdominal or transvaginal ultrasound. Cytogenetic tests of products of conception following culture were determined in both groups. RESULTS: Of the 223 early miscarriages, 143 had embryos and 80 did not. The abnormality rate differed significantly (61.5 % vs. 46.3 %, p < 0.05), with trisomy 18, 21 and 45X found only in miscarriages with embryos. There were no significant differences between groups in rates of triploidy, tetraploidy, mosaicism, structure and double abnormality. The female abortus rate was higher in miscarriages with or without embryonic poles, as well as in groups with normal and abnormal karyotypes. CONCLUSIONS: Chromosome distribution differs in miscarriages with or without embryonic poles. The ultrasound findings might offer different direction to determine the causes of early miscarriages. The higher female abortus rate may be associated with early selection.
PURPOSE: The objective of this study is to compare the chromosomal distribution of early miscarriages with or without embryonic poles. MATERIALS AND METHODS: It was a retrospective study of 223 women who underwent dilation and curettage (D&C) between 1995 and 2013 for early miscarriages. The presence or absence of a fetal pole was evaluated by abdominal or transvaginal ultrasound. Cytogenetic tests of products of conception following culture were determined in both groups. RESULTS: Of the 223 early miscarriages, 143 had embryos and 80 did not. The abnormality rate differed significantly (61.5 % vs. 46.3 %, p < 0.05), with trisomy 18, 21 and 45X found only in miscarriages with embryos. There were no significant differences between groups in rates of triploidy, tetraploidy, mosaicism, structure and double abnormality. The female abortus rate was higher in miscarriages with or without embryonic poles, as well as in groups with normal and abnormal karyotypes. CONCLUSIONS: Chromosome distribution differs in miscarriages with or without embryonic poles. The ultrasound findings might offer different direction to determine the causes of early miscarriages. The higher female abortus rate may be associated with early selection.
Authors: Tatyana V Nikitina; Igor N Lebedev; Natalia N Sukhanova; Elena A Sazhenova; Sergey A Nazarenko Journal: Fertil Steril Date: 2005-04 Impact factor: 7.329
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Authors: John Sebastian Sigmon; Matthew W Blanchard; Ralph S Baric; Timothy A Bell; Jennifer Brennan; Gudrun A Brockmann; A Wesley Burks; J Mauro Calabrese; Kathleen M Caron; Richard E Cheney; Dominic Ciavatta; Frank Conlon; David B Darr; James Faber; Craig Franklin; Timothy R Gershon; Lisa Gralinski; Bin Gu; Christiann H Gaines; Robert S Hagan; Ernest G Heimsath; Mark T Heise; Pablo Hock; Folami Ideraabdullah; J Charles Jennette; Tal Kafri; Anwica Kashfeen; Mike Kulis; Vivek Kumar; Colton Linnertz; Alessandra Livraghi-Butrico; K C Kent Lloyd; Cathleen Lutz; Rachel M Lynch; Terry Magnuson; Glenn K Matsushima; Rachel McMullan; Darla R Miller; Karen L Mohlke; Sheryl S Moy; Caroline E Y Murphy; Maya Najarian; Lori O'Brien; Abraham A Palmer; Benjamin D Philpot; Scott H Randell; Laura Reinholdt; Yuyu Ren; Steve Rockwood; Allison R Rogala; Avani Saraswatula; Christopher M Sassetti; Jonathan C Schisler; Sarah A Schoenrock; Ginger D Shaw; John R Shorter; Clare M Smith; Celine L St Pierre; Lisa M Tarantino; David W Threadgill; William Valdar; Barbara J Vilen; Keegan Wardwell; Jason K Whitmire; Lucy Williams; Mark J Zylka; Martin T Ferris; Leonard McMillan; Fernando Pardo Manuel de Villena Journal: Genetics Date: 2020-10-16 Impact factor: 4.402