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Literature DB >> 24875738

A centrosomal route for cancer genome instability.

Guillermo de Cárcer¹, Marcos Malumbres¹.

Abstract

Despite the widespread occurrence of aneuploidy in cancer cells, the molecular causes for chromosomal instability are not well established. Cyclin B2 is now shown to control a pathway - involving the centrosomal kinases aurora A and Plk1 and the tumour suppressor p53 - the alteration of which causes defective centrosome separation, aneuploidy and tumour development.

Entities: Disease Gene

Mesh：

Substances：

Year: 2014 PMID： 24875738 DOI： 10.1038/ncb2978

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

Review 1. A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy.

Authors: Ignacio Pérez de Castro; Guillermo de Cárcer; Marcos Malumbres
Journal: Carcinogenesis Date: 2007-01-27 Impact factor: 4.944

2. Oncogene-induced mitotic stress: p53 and pRb get mad too.

Authors: Marcos Malumbres
Journal: Cancer Cell Date: 2011-06-14 Impact factor: 31.743

3. Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction.

Authors: Balca R Mardin; Fikret G Agircan; Cornelia Lange; Elmar Schiebel
Journal: Curr Biol Date: 2011-06-30 Impact factor: 10.834

4. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.

Authors: Rocío Sotillo; Eva Hernando; Elena Díaz-Rodríguez; Julie Teruya-Feldstein; Carlos Cordón-Cardo; Scott W Lowe; Robert Benezra
Journal: Cancer Cell Date: 2006-12-28 Impact factor: 31.743

5. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

Authors: Scott L Carter; Aron C Eklund; Isaac S Kohane; Lyndsay N Harris; Zoltan Szallasi
Journal: Nat Genet Date: 2006-08-20 Impact factor: 38.330

6. Mutual inhibition of separase and Cdk1 by two-step complex formation.

Authors: Ingo H Gorr; Dominik Boos; Olaf Stemmann
Journal: Mol Cell Date: 2005-07-01 Impact factor: 17.970

Review 7. Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

Authors: Juan-Manuel Schvartzman; Rocio Sotillo; Robert Benezra
Journal: Nat Rev Cancer Date: 2010-02 Impact factor: 60.716

8. Overexpression of Separase induces aneuploidy and mammary tumorigenesis.

Authors: Nenggang Zhang; Gouquing Ge; Rene Meyer; Sumita Sethi; Dipanjan Basu; Subhashree Pradhan; Yi-Jue Zhao; Xiao-Nan Li; Wei-Wen Cai; Adel K El-Naggar; Veerabhadran Baladandayuthapani; Frances S Kittrell; Pulivarthi H Rao; Daniel Medina; Debananda Pati
Journal: Proc Natl Acad Sci U S A Date: 2008-08-26 Impact factor: 11.205

Review 9. The spindle-assembly checkpoint in space and time.

Authors: Andrea Musacchio; Edward D Salmon
Journal: Nat Rev Mol Cell Biol Date: 2007-04-11 Impact factor: 94.444

10. Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice.

Authors: Malini Mukherjee; Gouqing Ge; Nenggang Zhang; Eryong Huang; Lanelle V Nakamura; Marissa Minor; Viacheslav Fofanov; Pullivarthi H Rao; Alan Herron; Debananda Pati
Journal: PLoS One Date: 2011-07-25 Impact factor: 3.240

19 in total

1. Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A.

Authors: Akiko Kobayashi; Chieko Hashizume; Takayuki Dowaki; Richard W Wong
Journal: Cell Cycle Date: 2015 Impact factor: 4.534

Review 2. Issues in interpreting the in vivo activity of Aurora-A.

Authors: Elena Shagisultanova; Roland L Dunbrack; Erica A Golemis
Journal: Expert Opin Ther Targets Date: 2014-11-11 Impact factor: 6.902

Review 3. p53 in survival, death and metabolic health: a lifeguard with a licence to kill.

Authors: Flore Kruiswijk; Christiaan F Labuschagne; Karen H Vousden
Journal: Nat Rev Mol Cell Biol Date: 2015-07 Impact factor: 94.444

Review 4. Hallmarks of Cancer Applied to Oral and Oropharyngeal Carcinogenesis: A Scoping Review of the Evidence Gaps Found in Published Systematic Reviews.

Authors: Miguel Ángel González-Moles; Saman Warnakulasuriya; María López-Ansio; Pablo Ramos-García
Journal: Cancers (Basel) Date: 2022-08-08 Impact factor: 6.575

5. Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer.

Authors: Yukiko Yasuda; Akiko Sakai; Sachio Ito; Kaori Sasai; Akisada Ishizaki; Yoshiya Okano; Seito Kawahara; Yoshimi Jitsumori; Hiromasa Yamamoto; Nagahide Matsubara; Kenji Shimizu; Hiroshi Katayama
Journal: Biomed Rep Date: 2020-08-27

Review 6. Fanconi anaemia and cancer: an intricate relationship.

Authors: Grzegorz Nalepa; D Wade Clapp
Journal: Nat Rev Cancer Date: 2018-01-29 Impact factor: 60.716

Review 7. Revisiting tumour aneuploidy - the place of ploidy assessment in the molecular era.

Authors: Håvard E Danielsen; Manohar Pradhan; Marco Novelli
Journal: Nat Rev Clin Oncol Date: 2015-11-24 Impact factor: 66.675

8. Increased Genetic Instability and Accelerated Progression of Colitis-Associated Colorectal Cancer through Intestinal Epithelium-specific Deletion of Klf4.

Authors: Vincent W Yang; Yang Liu; Julie Kim; Kenneth R Shroyer; Agnieszka B Bialkowska
Journal: Mol Cancer Res Date: 2018-08-14 Impact factor: 5.852

Review 9. Role of NEK2A in human cancer and its therapeutic potentials.

Authors: Jiliang Xia; Reinaldo Franqui Machin; Zhimin Gu; Fenghuang Zhan
Journal: Biomed Res Int Date: 2015-02-01 Impact factor: 3.411

10. PCR-Based Simple Subgrouping Is Validated for Classification of Gliomas and Defines Negative Prognostic Copy Number Aberrations in IDH Mutant Gliomas.

Authors: Shunsuke Nakae; Hikaru Sasaki; Saeko Hayashi; Natsuki Hattori; Masanobu Kumon; Yuya Nishiyama; Kazuhide Adachi; Shinya Nagahisa; Takuro Hayashi; Joji Inamasu; Masato Abe; Mitsuhiro Hasegawa; Yuichi Hirose
Journal: PLoS One Date: 2015-11-11 Impact factor: 3.752