Literature DB >> 24855509

Age-related Deterioration of Hematopoietic Stem Cells.

Mi Jung Kim1, Min Hwan Kim2, Seung Ah Kim2, Jae Suk Chang3.   

Abstract

Aging is the process of system deterioration over time in the whole body. Stem cells are self-renewing and therefore have been considered exempt from the aging process. Earlier studies by Hayflick showed that there is an intrinsic limit to the number of divisions that mammalian somatic cells can undergo, and cycling kinetics and ontogeny-related studies strongly suggest that even the most primitive stem cell functions exhibit a certain degree of aging. Despite these findings, studies on the effects of aging on stem cell functions are inconclusive. Here we review the age-related properties of hematopoietic stem cells in terms of intrinsic and extrinsic alterations, proliferative potential, signaling molecules, telomere and telomerase, senescence and cancer issues, regenerative potential and other indications of stem cell aging are discussed in detail.

Entities:  

Keywords:  Aging; Hematopoietic stem cells; Phenotype shift; Proliferative potential

Year:  2008        PMID： 24855509      PMCID： PMC4021776          DOI： 10.15283/ijsc.2008.1.1.55

Source DB:  PubMed          Journal:  Int J Stem Cells        ISSN： 2005-3606            Impact factor:   2.500


  57 in total

1.  "Stemness": transcriptional profiling of embryonic and adult stem cells.

Authors:  Miguel Ramalho-Santos; Soonsang Yoon; Yumi Matsuzaki; Richard C Mulligan; Douglas A Melton
Journal:  Science       Date:  2002-09-12       Impact factor: 47.728

Review 2.  The journey of developing hematopoietic stem cells.

Authors:  Hanna K A Mikkola; Stuart H Orkin
Journal:  Development       Date:  2006-10       Impact factor: 6.868

3.  Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells.

Authors:  M Engelhardt; R Kumar; J Albanell; R Pettengell; W Han; M A Moore
Journal:  Blood       Date:  1997-07-01       Impact factor: 22.113

Review 4.  Stems cells and the pathways to aging and cancer.

Authors:  Derrick J Rossi; Catriona H M Jamieson; Irving L Weissman
Journal:  Cell       Date:  2008-02-22       Impact factor: 41.582

5.  Ontogeny of the haemopoietic system: yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo.

Authors:  M A Moore; D Metcalf
Journal:  Br J Haematol       Date:  1970-03       Impact factor: 6.998

6.  p53 mutant mice that display early ageing-associated phenotypes.

Authors:  Stuart D Tyner; Sundaresan Venkatachalam; Jene Choi; Stephen Jones; Nader Ghebranious; Herbert Igelmann; Xiongbin Lu; Gabrielle Soron; Benjamin Cooper; Cory Brayton; Sang Hee Park; Timothy Thompson; Gerard Karsenty; Allan Bradley; Lawrence A Donehower
Journal:  Nature       Date:  2002-01-03       Impact factor: 49.962

7.  Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells.

Authors:  Wolf C Prall; Akos Czibere; Marcus Jäger; Dimitrios Spentzos; Towia A Libermann; Norbert Gattermann; Rainer Haas; Manuel Aivado
Journal:  Mech Ageing Dev       Date:  2007-07-04       Impact factor: 5.432

8.  Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

Authors:  H Vaziri; W Dragowska; R C Allsopp; T E Thomas; C B Harley; P M Lansdorp
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-11       Impact factor: 11.205

Review 9.  ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia.

Authors:  M H G P Raaijmakers
Journal:  Leukemia       Date:  2007-07-26       Impact factor: 11.528

10.  Major age-related changes of mouse hematopoietic stem/progenitor cells.

Authors:  Mijung Kim; Hee-Bom Moon; Gerald J Spangrude
Journal:  Ann N Y Acad Sci       Date:  2003-05       Impact factor: 5.691
View more
  11 in total

Review 1.  Clinical application of stem cells for therapeutic angiogenesis in patients with peripheral arterial disease.

Authors:  Kyung-Bok Lee; Dong-Ik Kim
Journal:  Int J Stem Cells       Date:  2009-05       Impact factor: 2.500

Review 2.  Hematopoietic stem and progenitor cell signaling in the niche.

Authors:  Stephanie N Hurwitz; Seul K Jung; Peter Kurre
Journal:  Leukemia       Date:  2020-10-19       Impact factor: 11.528

3.  In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.

Authors:  Maximilian Richter; Kamola Saydaminova; Roma Yumul; Rohini Krishnan; Jing Liu; Eniko-Eva Nagy; Manvendra Singh; Zsuzsanna Izsvák; Roberto Cattaneo; Wolfgang Uckert; Donna Palmer; Philip Ng; Kevin G Haworth; Hans-Peter Kiem; Anja Ehrhardt; Thalia Papayannopoulou; André Lieber
Journal:  Blood       Date:  2016-08-23       Impact factor: 22.113

Review 4.  Epigenetic function of activation-induced cytidine deaminase and its link to lymphomagenesis.

Authors:  Pilar M Dominguez; Rita Shaknovich
Journal:  Front Immunol       Date:  2014-12-18       Impact factor: 7.561

5.  Quantitative 3D Telomeric Imaging of Buccal Cells Reveals Alzheimer's Disease-Specific Signatures.

Authors:  Angeles Garcia; Shubha Mathur; Maria Carmela Kalaw; Elizabeth McAvoy; James Anderson; Angela Luedke; Justine Itorralba; Sabine Mai
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

Review 6.  Autologous Transplantation for Older Adults with AML.

Authors:  Beatrice U Mueller; Katja Seipel; Ulrike Bacher; Thomas Pabst
Journal:  Cancers (Basel)       Date:  2018-09-19       Impact factor: 6.639

Review 7.  Divide and conquer: two stem cell populations in squamous epithelia, reserves and the active duty forces.

Authors:  Spencer Dunaway; Alexandra Rothaus; Yuhang Zhang; Ana Luisa Kadekaro; Thomas Andl; Claudia D Andl
Journal:  Int J Oral Sci       Date:  2019-08-27       Impact factor: 6.344

8.  Reduction of Proliferating Olfactory Cells and Low Expression of Extracellular Matrix Genes Are Hallmarks of the Aged Olfactory Mucosa.

Authors:  Rumi Ueha; Shigeyuki Shichino; Satoshi Ueha; Kenji Kondo; Shu Kikuta; Hironobu Nishijima; Kouji Matsushima; Tatsuya Yamasoba
Journal:  Front Aging Neurosci       Date:  2018-03-27       Impact factor: 5.750

9.  A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support.

Authors:  Amar Desai; Yongyou Zhang; Youngsoo Park; Dawn M Dawson; Gretchen A Larusch; Lakshmi Kasturi; David Wald; Joseph M Ready; Stanton L Gerson; Sanford D Markowitz
Journal:  Haematologica       Date:  2018-02-22       Impact factor: 9.941

Review 10.  Hematopoietic Stem Cells and Their Roles in Tissue Regeneration.

Authors:  Ji Yoon Lee; Seok-Ho Hong
Journal:  Int J Stem Cells       Date:  2020-03-30       Impact factor: 2.500
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.