BACKGROUND: Hepatocellular adenoma (HCA) is a rare benign liver epithelial tumour that can require surgery. This retrospective study reports a 23-year experience of open and laparoscopic resections for HCA. METHODS: Patients with a histological diagnosis of HCA were included in this analysis. Surgical resection was performed in all symptomatic patients and in those with lesions measuring >5 cm. RESULTS: Between 1989 and 2012, 62 patients, 59 of whom were female, underwent surgery for HCA (26 by open surgery and 36 by laparoscopic surgery). Overall, 96.6% of female patients had a history of contraceptive use; 54.8% of patients presented with abdominal pain and 11.2% with haemorrhage; the remaining patients were asymptomatic. Patients who underwent laparoscopy had smaller lesions (mean ± standard deviation diameter: 68.3 ± 35.2 mm versus 91.9 ± 42.5 mm; P = 0.022). Operatively, laparoscopic and open liver resection did not differ except in the number of pedicle clamps, which was significantly lower in the laparoscopic group (27.8% versus 57.7% of patients; P = 0.008). Postoperative variables did not differ between the groups. Mortality was nil. Two surgical specimens were classified as HCA/borderline hepatocellular carcinoma. At the 3-year follow-up, all patients were alive with no recurrence of HCA. CONCLUSIONS: Open and laparoscopic liver resections are both safe and feasible approaches for the surgical management of HCA. However, laparoscopic liver resections may be limited by lesion size and location and require advanced surgical skills.
BACKGROUND:Hepatocellular adenoma (HCA) is a rare benign liver epithelial tumour that can require surgery. This retrospective study reports a 23-year experience of open and laparoscopic resections for HCA. METHODS:Patients with a histological diagnosis of HCA were included in this analysis. Surgical resection was performed in all symptomatic patients and in those with lesions measuring >5 cm. RESULTS: Between 1989 and 2012, 62 patients, 59 of whom were female, underwent surgery for HCA (26 by open surgery and 36 by laparoscopic surgery). Overall, 96.6% of female patients had a history of contraceptive use; 54.8% of patients presented with abdominal pain and 11.2% with haemorrhage; the remaining patients were asymptomatic. Patients who underwent laparoscopy had smaller lesions (mean ± standard deviation diameter: 68.3 ± 35.2 mm versus 91.9 ± 42.5 mm; P = 0.022). Operatively, laparoscopic and open liver resection did not differ except in the number of pedicle clamps, which was significantly lower in the laparoscopic group (27.8% versus 57.7% of patients; P = 0.008). Postoperative variables did not differ between the groups. Mortality was nil. Two surgical specimens were classified as HCA/borderline hepatocellular carcinoma. At the 3-year follow-up, all patients were alive with no recurrence of HCA. CONCLUSIONS: Open and laparoscopic liver resections are both safe and feasible approaches for the surgical management of HCA. However, laparoscopic liver resections may be limited by lesion size and location and require advanced surgical skills.
Authors: P Bioulac-Sage; C Balabaud; P Bedossa; J Y Scoazec; L Chiche; A P Dhillon; L Ferrell; V Paradis; T Roskams; V Vilgrain; I R Wanless; J Zucman-Rossi Journal: J Hepatol Date: 2007-01-02 Impact factor: 25.083
Authors: S M van Aalten; T Terkivatan; R A de Man; D J van der Windt; N F M Kok; R Dwarkasing; J N M Ijzermans Journal: Dig Surg Date: 2010-04-01 Impact factor: 2.588
Authors: Julien Calderaro; Philippe Labrune; Guillaume Morcrette; Sandra Rebouissou; Dominique Franco; Sophie Prévot; Alberto Quaglia; Pierre Bedossa; Louis Libbrecht; Luigi Terracciano; G Peter A Smit; Paulette Bioulac-Sage; Jessica Zucman-Rossi Journal: J Hepatol Date: 2012-10-06 Impact factor: 25.083
Authors: Giovanni Vennarecci; Roberto Santoro; Mario Antonini; Cecilia Ceribelli; Andrea Laurenzi; Enrico Moroni; Mirco Burocchi; Pasquale Lepiane; Giuseppe Maria Ettorre Journal: World J Hepatol Date: 2013-03-27
Authors: Joseph F Buell; Daniel Cherqui; David A Geller; Nicholas O'Rourke; David Iannitti; Ibrahim Dagher; Alan J Koffron; Mark Thomas; Brice Gayet; Ho Seong Han; Go Wakabayashi; Giulio Belli; Hironori Kaneko; Chen-Guo Ker; Olivier Scatton; Alexis Laurent; Eddie K Abdalla; Prosanto Chaudhury; Erik Dutson; Clark Gamblin; Michael D'Angelica; David Nagorney; Giuliano Testa; Daniel Labow; Derrik Manas; Ronnie T Poon; Heidi Nelson; Robert Martin; Bryan Clary; Wright C Pinson; John Martinie; Jean-Nicolas Vauthey; Robert Goldstein; Sasan Roayaie; David Barlet; Joseph Espat; Michael Abecassis; Myrddin Rees; Yuman Fong; Kelly M McMasters; Christoph Broelsch; Ron Busuttil; Jacques Belghiti; Steven Strasberg; Ravi S Chari Journal: Ann Surg Date: 2009-11 Impact factor: 12.969
Authors: Riccardo Memeo; Vito de Blasi; René Adam; Diane Goéré; Daniel Azoulay; Ahmet Ayav; Emilie Gregoire; Reza Kianmanesh; Francis Navarro; Antonio Sa Cunha; Patrick Pessaux Journal: HPB (Oxford) Date: 2016-07-05 Impact factor: 3.647
Authors: Nicola de'Angelis; Benjamin Menahem; Philippe Compagnon; Jean Claude Merle; Francesco Brunetti; Alain Luciani; Daniel Cherqui; Alexis Laurent Journal: Surg Endosc Date: 2017-04-04 Impact factor: 4.584