Literature DB >> 18984149

The autistic neuron: troubled translation?

Raymond J Kelleher1, Mark F Bear.   

Abstract

Autism is a complex genetic disorder, but single-gene disorders with a high prevalence of autism offer insight into its pathogenesis. Recent evidence suggests that some molecular defects in autism may interfere with the mechanisms of synaptic protein synthesis. We propose that aberrant synaptic protein synthesis may represent one possible pathway leading to autistic phenotypes, including cognitive impairment and savant abilities.

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Year:  2008        PMID： 18984149     DOI： 10.1016/j.cell.2008.10.017

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  305 in total

Review 1.  Local RNA translation at the synapse and in disease.

Authors:  Liqun Liu-Yesucevitz; Gary J Bassell; Aaron D Gitler; Anne C Hart; Eric Klann; Joel D Richter; Stephen T Warren; Benjamin Wolozin
Journal:  J Neurosci       Date:  2011-11-09       Impact factor: 6.167

2.  The metabotropic glutamate receptor activates the lipid kinase PI3K in Drosophila motor neurons through the calcium/calmodulin-dependent protein kinase II and the nonreceptor tyrosine protein kinase DFak.

Authors:  Curtis Chun-Jen Lin; James B Summerville; Eric Howlett; Michael Stern
Journal:  Genetics       Date:  2011-04-21       Impact factor: 4.562

Review 3.  Oxytocin receptor and Mecp2 308/Y knockout mice exhibit altered expression of autism-related social behaviors.

Authors:  Roger L H Pobbe; Brandon L Pearson; D Caroline Blanchard; Robert J Blanchard
Journal:  Physiol Behav       Date:  2012-03-03

Review 4.  The trouble with spines in fragile X syndrome: density, maturity and plasticity.

Authors:  C X He; C Portera-Cailliau
Journal:  Neuroscience       Date:  2012-04-20       Impact factor: 3.590

5.  Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors.

Authors:  Gaga Kochlamazashvili; Oleg Senkov; Sergei Grebenyuk; Catrina Robinson; Mei-Fang Xiao; Katharina Stummeyer; Rita Gerardy-Schahn; Andreas K Engel; Larry Feig; Alexey Semyanov; Vishnu Suppiramaniam; Melitta Schachner; Alexander Dityatev
Journal:  J Neurosci       Date:  2010-03-17       Impact factor: 6.167

6.  Insulin-Like Growth Factor II Targets the mTOR Pathway to Reverse Autism-Like Phenotypes in Mice.

Authors:  Adam B Steinmetz; Sarah A Stern; Amy S Kohtz; Giannina Descalzi; Cristina M Alberini
Journal:  J Neurosci       Date:  2017-12-07       Impact factor: 6.167

7.  Protocadherin α (PCDHA) as a novel susceptibility gene for autism.

Authors:  Ayyappan Anitha; Ismail Thanseem; Kazuhiko Nakamura; Kazuo Yamada; Yoshimi Iwayama; Tomoko Toyota; Yasuhide Iwata; Katsuaki Suzuki; Toshiro Sugiyama; Masatsugu Tsujii; Takeo Yoshikawa; Norio Mori
Journal:  J Psychiatry Neurosci       Date:  2013-05       Impact factor: 6.186

8.  Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function.

Authors:  Rhonda L McFleder; Fernanda Mansur; Joel D Richter
Journal:  Cell Rep       Date:  2017-07-18       Impact factor: 9.423

9.  Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice.

Authors:  Kirsty Sawicka; Alexander Pyronneau; Miranda Chao; Michael V L Bennett; R Suzanne Zukin
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-23       Impact factor: 11.205

Review 10.  Activity-dependent neuronal signalling and autism spectrum disorder.

Authors:  Daniel H Ebert; Michael E Greenberg
Journal:  Nature       Date:  2013-01-17       Impact factor: 49.962
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