Literature DB >> 2484354

Effect on blood, liver, and kidney variables of age and of dosing rats with lead acetate orally or via the drinking water.

G O Korsrud1, J B Meldrum.   

Abstract

Levels of lead in the livers and kidneys of rats increased in proportion to the dose of lead acetate that the rats were given orally or in the drinking water. The activities of delta-aminolevulinic acid dehydratase (DALAD) in blood and liver decreased when the rats were dosed with lead, whereas glutathione levels in the blood increased. The decrease in the activity of blood DALAD was the most sensitive indicator of lead toxicity. Levels of lead in the livers and kidneys decreased after 3, 7, and 14 d of lead withdrawal. The activities of blood DALAD increased after 3 d of lead withdrawal. Groups of rats that initially weighted an average of 140 g were killed at weekly intervals for 6 wk. Blood hematocrits and liver glutathione levels increased, and blood DALAD and activated DALAD from blood decreased with increasing age of the rats. Activated DALAD activities from liver increased after the first week of the study.

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Year:  1988        PMID： 2484354     DOI： 10.1007/bf02795453

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  29 in total

1.  Comparative studies on the effect of cadmium, cobalt, lead, and selenium on hepatic microsomal monooxygenase enzymes and glutathione levels in mice.

Authors:  R R Dalvi; T J Robbins
Journal:  J Environ Pathol Toxicol       Date:  1978 May-Jun

2.  Interaction of zinc and lead on delta-aminolevulinate dehydratase.

Authors:  V N Finelli; D S Klauder; M A Karaffa; H G Petering
Journal:  Biochem Biophys Res Commun       Date:  1975-07-08       Impact factor: 3.575

3.  Lead and mercury residues in kidney and liver of Canadian slaughter animals.

Authors:  M G Prior
Journal:  Can J Comp Med       Date:  1976-01

4.  European standardized method for the determination of delta-aminolevulinic acid dehydratase activity in blood.

Authors:  A Berlin; K H Schaller
Journal:  Z Klin Chem Klin Biochem       Date:  1974-08

5.  Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.

Authors:  J Sedlak; R H Lindsay
Journal:  Anal Biochem       Date:  1968-10-24       Impact factor: 3.365

6.  Lead poisoning in cattle: brain lesions and hematologic changes.

Authors:  R G Christian; L Tryphonas
Journal:  Am J Vet Res       Date:  1971-02       Impact factor: 1.156

7.  Site of action of metals on the aminolevulinic acid dehydratase of human erythrocytes.

Authors:  A Trevisan; G P Gori; A Zangirolami; C Benevento; A Rosa; P Chiesura
Journal:  Enzyme       Date:  1980

8.  Chemical and biological monitoring of chronic lead poisoning in the rat. Implications to the assessment of hazard of low-level lead.

Authors:  D C Wigfield; C L Chakrabarti; S C Wright; J A Eastwood; R Karkowska; P M Johnson
Journal:  J Appl Toxicol       Date:  1986-10       Impact factor: 3.446

9.  The effect of chronic ingestion of lead on gastrointestinal transit in rats.

Authors:  C T Walsh; E B Ryden
Journal:  Toxicol Appl Pharmacol       Date:  1984-09-30       Impact factor: 4.219

10.  Effect of diet on the response in rats to lead acetate given orally or in the drinking water.

Authors:  G O Korsrud; J B Meldrum
Journal:  Biol Trace Elem Res       Date:  1988 Sep-Dec       Impact factor: 3.738
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  2 in total

1.  Biokinetics of lead in various organs of rats using radiotracer technique.

Authors:  D Kaushal; M L Garg; M R Bansal; M P Bansal
Journal:  Biol Trace Elem Res       Date:  1996       Impact factor: 3.738

2.  Effect of diet on the response in rats to lead acetate given orally or in the drinking water.

Authors:  G O Korsrud; J B Meldrum
Journal:  Biol Trace Elem Res       Date:  1988 Sep-Dec       Impact factor: 3.738
  2 in total

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