Literature DB >> 7363875

Site of action of metals on the aminolevulinic acid dehydratase of human erythrocytes.

A Trevisan, G P Gori, A Zangirolami, C Benevento, A Rosa, P Chiesura.   

Abstract

The site of action of four metals (copper, lead, nickel and zinc) on the aminolevulinic acid dehydratase of human erythrocytes was studied. Data obtained after denaturation of allosteric sites with heat treatment and after simultaneous incubation with two metals suggest the following conclusions: copper acts on the catalytic site, whereas lead, nickel and zinc act on the allosteric sites; zinc and nickel act on the same allosteric (metallic) site; zinc and lead only partially act on the same metallic site; nickel and lead act on different allosteric sites.

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Year:  1980        PMID： 7363875     DOI： 10.1159/000459212

Source DB:  PubMed          Journal:  Enzyme        ISSN： 0013-9432


  5 in total

1.  Postulated mode of action of lead on aminolevulinic acid dehydratase in chronic exposure.

Authors:  A Trevisan; V Chinello; A Buzzo; G P Gori
Journal:  Int Arch Occup Environ Health       Date:  1981       Impact factor: 3.015

2.  Interaction of metals from group 10 (Ni, Pd, and Pt) and 11 (Cu, Ag, and Au) with human blood δ-ALA-D: in vitro and in silico studies.

Authors:  Cláudia Vargas Klimaczewski; Pablo Andrei Nogara; Nilda Vargas Barbosa; João Batista Teixeira da Rocha
Journal:  Environ Sci Pollut Res Int       Date:  2018-09-01       Impact factor: 4.223

3.  Purification and properties of 5-aminolaevulinate dehydratase from human erythrocytes.

Authors:  P N Gibbs; A G Chaudhry; P M Jordan
Journal:  Biochem J       Date:  1985-08-15       Impact factor: 3.857

4.  Delta aminolevulinic acid dehydratase amounts in lead-exposed subjects: description of a method correlated with the immunoturbidimetric assay.

Authors:  N Despaux-Pagès; E Comoy; C Bohuon; C Boudène
Journal:  Int Arch Occup Environ Health       Date:  1986       Impact factor: 3.015

5.  Effect on blood, liver, and kidney variables of age and of dosing rats with lead acetate orally or via the drinking water.

Authors:  G O Korsrud; J B Meldrum
Journal:  Biol Trace Elem Res       Date:  1988 Sep-Dec       Impact factor: 3.738
  5 in total

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