Literature DB >> 2483994

Inducible ribosomal RNA methylation in Streptomyces lividans, conferring resistance to lincomycin.

G Jenkins1, M Zalacain, E Cundliffe.   

Abstract

Streptomyces lividans TK21 possesses inducible ribosomal RNA methylase activity that confers high-level resistance to lincomycin and lower levels of resistance to certain macrolides. The methylase gene (designated lrm) is inducible by erythromycin and other macrolides and also by celesticetin (a lincosamide) but not by lincomycin. The lrm enzyme monomethylates the N6-amino group of adenosine at position 2058 within 23S-like ribosomal RNA.

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Year:  1989        PMID： 2483994     DOI： 10.1099/00221287-135-12-3281

Source DB:  PubMed          Journal:  J Gen Microbiol        ISSN： 0022-1287


  8 in total

Review 1.  Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.

Authors:  M C Roberts; J Sutcliffe; P Courvalin; L B Jensen; J Rood; H Seppala
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

2.  Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.

Authors:  Mingfu Liu; Stephen Douthwaite
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-04       Impact factor: 11.205

3.  Zwittermicin A resistance gene from Bacillus cereus.

Authors:  J L Milner; E A Stohl; J Handelsman
Journal:  J Bacteriol       Date:  1996-07       Impact factor: 3.490

4.  Glycosylation of macrolide antibiotics in extracts of Streptomyces lividans.

Authors:  E Cundliffe
Journal:  Antimicrob Agents Chemother       Date:  1992-02       Impact factor: 5.191

5.  The macrolide-lincosamide-streptogramin B resistance phenotypes characterized by using a specifically deleted, antibiotic-sensitive strain of Streptomyces lividans.

Authors:  J L Pernodet; S Fish; M H Blondelet-Rouault; E Cundliffe
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

6.  Transformation of Streptomyces lincolnensis protoplasts with plasmid vectors.

Authors:  Z Jandová; P Tichý
Journal:  Folia Microbiol (Praha)       Date:  1992       Impact factor: 2.099

7.  Cloning of a lincosamide resistance determinant from Streptomyces caelestis, the producer of celesticetin, and characterization of the resistance mechanism.

Authors:  M J Calcutt; E Cundliffe
Journal:  J Bacteriol       Date:  1990-08       Impact factor: 3.490

8.  The WblC/WhiB7 Transcription Factor Controls Intrinsic Resistance to Translation-Targeting Antibiotics by Altering Ribosome Composition.

Authors:  Ju-Hyung Lee; Ji-Sun Yoo; Yeonbum Kim; Jong-Seo Kim; Eun-Jin Lee; Jung-Hye Roe
Journal:  mBio       Date:  2020-04-14       Impact factor: 7.867
  8 in total

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