Literature DB >> 2376570

Cloning of a lincosamide resistance determinant from Streptomyces caelestis, the producer of celesticetin, and characterization of the resistance mechanism.

M J Calcutt1, E Cundliffe.   

Abstract

Self-resistance has been investigated in Streptomyces caelestis (producer of the lincosamide antibiotic celesticetin), from which a lincosamide resistance determinant (clr) has been isolated on a 1-kilobase DNA fragment and cloned in Streptomyces lividans. The clr product is a specific methylase which produces a single residue of N6-monomethyladenine in 23S rRNA at position 2058, thereby rendering the 50S ribosmal subunit resistant to the action of lincosamides.

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Year:  1990        PMID： 2376570      PMCID： PMC213311          DOI： 10.1128/jb.172.8.4710-4714.1990

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  15 in total

1.  Inducible ribosomal RNA methylation in Streptomyces lividans, conferring resistance to lincomycin.

Authors:  G Jenkins; M Zalacain; E Cundliffe
Journal:  J Gen Microbiol       Date:  1989-12

2.  Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis.

Authors:  P A Skeggs; J Thompson; E Cundliffe
Journal:  Mol Gen Genet       Date:  1985

3.  Alteration of 23 S ribosomal RNA and erythromycin-induced resistance to lincomycin and spiramycin in Staphylococcus aureus.

Authors:  C J Lai; B Weisblum; S R Fahnestock; M Nomura
Journal:  J Mol Biol       Date:  1973-02-15       Impact factor: 5.469

Review 4.  Translational attenuation: the regulation of bacterial resistance to the macrolide-lincosamide-streptogramin B antibiotics.

Authors:  D Dubnau
Journal:  CRC Crit Rev Biochem       Date:  1984

5.  Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli.

Authors:  C D Sigmund; M Ettayebi; E A Morgan
Journal:  Nucleic Acids Res       Date:  1984-06-11       Impact factor: 16.971

Review 6.  Inducible erythromycin resistance in bacteria.

Authors:  B Weisblum
Journal:  Br Med Bull       Date:  1984-01       Impact factor: 4.291

7.  A family of r-determinants in Streptomyces spp. that specifies inducible resistance to macrolide, lincosamide, and streptogramin type B antibiotics.

Authors:  Y Fujisawa; B Weisblum
Journal:  J Bacteriol       Date:  1981-05       Impact factor: 3.490

8.  Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics.

Authors:  R Skinner; E Cundliffe; F J Schmidt
Journal:  J Biol Chem       Date:  1983-10-25       Impact factor: 5.157

9.  Coupled transcription--translation in extracts of Streptomyces lividans.

Authors:  J Thompson; S Rae; E Cundliffe
Journal:  Mol Gen Genet       Date:  1984

10.  Cloning and expression of the tyrosinase gene from Streptomyces antibioticus in Streptomyces lividans.

Authors:  E Katz; C J Thompson; D A Hopwood
Journal:  J Gen Microbiol       Date:  1983-09
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  12 in total

Review 1.  Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.

Authors:  M C Roberts; J Sutcliffe; P Courvalin; L B Jensen; J Rood; H Seppala
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

Review 2.  Avoidance of suicide in antibiotic-producing microbes.

Authors:  Eric Cundliffe; Arnold L Demain
Journal:  J Ind Microbiol Biotechnol       Date:  2010-05-06       Impact factor: 3.346

3.  Hybridization analysis and mapping of the celesticetin gene cluster revealed genes shared with lincomycin biosynthesis.

Authors:  L Cermák; J Novotná; M Ságova-Marecková; J Kopecký; L Najmanová; J Janata
Journal:  Folia Microbiol (Praha)       Date:  2007       Impact factor: 2.099

4.  Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocida.

Authors:  Benoit Desmolaize; Simon Rose; Cornelia Wilhelm; Ralf Warrass; Stephen Douthwaite
Journal:  Antimicrob Agents Chemother       Date:  2011-06-27       Impact factor: 5.191

Review 5.  Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria.

Authors:  Hiroshi Ogawara
Journal:  Molecules       Date:  2019-09-21       Impact factor: 4.411

Review 6.  Erythromycin resistance by ribosome modification.

Authors:  B Weisblum
Journal:  Antimicrob Agents Chemother       Date:  1995-03       Impact factor: 5.191

Review 7.  Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms.

Authors:  Hiroshi Ogawara
Journal:  Molecules       Date:  2018-06-18       Impact factor: 4.411

8.  Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.

Authors:  Mingfu Liu; Stephen Douthwaite
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

9.  The macrolide-lincosamide-streptogramin B resistance phenotypes characterized by using a specifically deleted, antibiotic-sensitive strain of Streptomyces lividans.

Authors:  J L Pernodet; S Fish; M H Blondelet-Rouault; E Cundliffe
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

10.  Multiplex PCR to identify macrolide resistance determinants in Mannheimia haemolytica and Pasteurella multocida.

Authors:  Simon Rose; Benoit Desmolaize; Puneet Jaju; Cornelia Wilhelm; Ralf Warrass; Stephen Douthwaite
Journal:  Antimicrob Agents Chemother       Date:  2012-05-07       Impact factor: 5.191
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