Jin Young Ahn1, Je Eun Song1, Min Hyung Kim1, Heun Choi1, Jae Kyung Kim1, Hea Won Ann1, Jung Ho Kim1, Yongduk Jeon1, Su Jin Jeong1, Sun Bean Kim1, Nam Su Ku2, Sang Hoon Han2, Young Goo Song2, Dongeun Yong3, Kyungwon Lee3, June Myung Kim2, Jun Yong Choi4. 1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. 2. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea; AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea. 3. Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea. 4. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea; AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea. Electronic address: seran@yuhs.ac.
Abstract
BACKGROUND: Carbapenem resistance among gram-negative bacilli is an emerging threat worldwide. The objective of this study was to identify risk factors for the acquisition of carbapenem-resistant Escherichia coli (CRE). METHODS: We conducted a matched case-control study comprising 57 cases of acquisition of CRE and 114 controls (1:2 matched) selected from patients with a culture of carbapenem-susceptible E coli between January 2006 and December 2010 at a 2000-bed tertiary care center in South Korea. RESULTS: On univariate analysis, previous use of carbapenem (P < .01), fluoroquinolone (P < .01), and glycopeptide (P < .01), as well as length of hospital stay (P < .05), were significantly associated with CRE acquisition. On multivariate analysis, previous use of carbapenem (odds ratio [OR], 4.56; 95% confidence interval [CI] 1.44-14.46; P = .01) and previous use of fluoroquinolone (OR, 2.81; 95% CI, 1.14-6.99; P = .03) were independent risk factors. CONCLUSIONS: At this institute, the antibiotic selective pressure of carbapenems and fluoroquinolones was shown to be an important risk factor for the acquisition of CRE.
BACKGROUND:Carbapenem resistance among gram-negative bacilli is an emerging threat worldwide. The objective of this study was to identify risk factors for the acquisition of carbapenem-resistant Escherichia coli (CRE). METHODS: We conducted a matched case-control study comprising 57 cases of acquisition of CRE and 114 controls (1:2 matched) selected from patients with a culture of carbapenem-susceptible E coli between January 2006 and December 2010 at a 2000-bed tertiary care center in South Korea. RESULTS: On univariate analysis, previous use of carbapenem (P < .01), fluoroquinolone (P < .01), and glycopeptide (P < .01), as well as length of hospital stay (P < .05), were significantly associated with CRE acquisition. On multivariate analysis, previous use of carbapenem (odds ratio [OR], 4.56; 95% confidence interval [CI] 1.44-14.46; P = .01) and previous use of fluoroquinolone (OR, 2.81; 95% CI, 1.14-6.99; P = .03) were independent risk factors. CONCLUSIONS: At this institute, the antibiotic selective pressure of carbapenems and fluoroquinolones was shown to be an important risk factor for the acquisition of CRE.
Authors: Q Wang; Y Zhang; X Yao; H Xian; Y Liu; H Li; H Chen; X Wang; R Wang; C Zhao; B Cao; H Wang Journal: Eur J Clin Microbiol Infect Dis Date: 2016-07-11 Impact factor: 3.267
Authors: Benoit Pilmis; Vincent Jullien; Alexis Tabah; Jean-Ralph Zahar; Christian Brun-Buisson Journal: Ann Intensive Care Date: 2017-11-10 Impact factor: 6.925
Authors: Hyo Jin Lee; Jae Ki Choi; Sung Yeon Cho; Si Hyun Kim; Sun Hee Park; Su Mi Choi; Dong Gun Lee; Jung Hyun Choi; Jin Hong Yoo Journal: Infect Chemother Date: 2016-09-08