Literature DB >> 24825474

The Hippo signaling pathway in stem cell biology and cancer.

Jung-Soon Mo1, Hyun Woo Park1, Kun-Liang Guan2.   

Abstract

The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue homeostasis and organ size control by regulating tissue-specific stem cells. Moreover, this pathway plays a prominent role in tissue repair and regeneration. Dysregulation of the Hippo pathway is associated with cancer development. Recent studies have revealed a complex network of upstream inputs, including cell density, mechanical sensation, and G-protein-coupled receptor (GPCR) signaling, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway in stem cell biology and its potential implications in tissue homeostasis and cancer.
© 2014 The Authors.

Entities:  

Keywords:  Hippo pathway; YAP; cancer; regeneration; stem cell

Mesh：

Substances：

Year:  2014        PMID： 24825474      PMCID： PMC4197875          DOI： 10.15252/embr.201438638

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  154 in total

1.  TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.

Authors:  A Vassilev; K J Kaneko; H Shu; Y Zhao; M L DePamphilis
Journal:  Genes Dev       Date:  2001-05-15       Impact factor: 11.361

Review 2.  Myocyte death, growth, and regeneration in cardiac hypertrophy and failure.

Authors:  Bernardo Nadal-Ginard; Jan Kajstura; Annarosa Leri; Piero Anversa
Journal:  Circ Res       Date:  2003-02-07       Impact factor: 17.367

3.  "Stemness": transcriptional profiling of embryonic and adult stem cells.

Authors:  Miguel Ramalho-Santos; Soonsang Yoon; Yumi Matsuzaki; Richard C Mulligan; Douglas A Melton
Journal:  Science       Date:  2002-09-12       Impact factor: 47.728

4.  TAZ as a novel enhancer of MyoD-mediated myogenic differentiation.

Authors:  Hana Jeong; Sujung Bae; Su Yeon An; Mi Ran Byun; Jun-Ha Hwang; Michael B Yaffe; Jeong-Ho Hong; Eun Sook Hwang
Journal:  FASEB J       Date:  2010-05-13       Impact factor: 5.191

5.  A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway.

Authors:  Javier Menéndez; Ainhoa Pérez-Garijo; Manuel Calleja; Ginés Morata
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-02       Impact factor: 11.205

6.  Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila.

Authors:  Madhuri Kango-Singh; Riitta Nolo; Chunyao Tao; Patrik Verstreken; P Robin Hiesinger; Hugo J Bellen; Georg Halder
Journal:  Development       Date:  2002-12       Impact factor: 6.868

7.  The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila.

Authors:  Chiao-Lin Chen; Kathleen M Gajewski; Fisun Hamaratoglu; Wouter Bossuyt; Leticia Sansores-Garcia; Chunyao Tao; Georg Halder
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-23       Impact factor: 11.205

8.  salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.

Authors:  Nicolas Tapon; Kieran F Harvey; Daphne W Bell; Doke C R Wahrer; Taryn A Schiripo; Daniel A Haber; Iswar K Hariharan
Journal:  Cell       Date:  2002-08-23       Impact factor: 41.582

9.  Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.

Authors:  Shimako Yamamoto; Guiping Yang; Daniela Zablocki; Jing Liu; Chull Hong; Song-Jung Kim; Sandra Soler; Mari Odashima; Jill Thaisz; Ghassan Yehia; Carlos A Molina; Atsuko Yatani; Dorothy E Vatner; Stephen F Vatner; Junichi Sadoshima
Journal:  J Clin Invest       Date:  2003-05       Impact factor: 14.808

10.  The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

Authors:  B M McCartney; R M Kulikauskas; D R LaJeunesse; R G Fehon
Journal:  Development       Date:  2000-03       Impact factor: 6.868
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  268 in total

1.  Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest.

Authors:  Lauren J Manderfield; Haig Aghajanian; Kurt A Engleka; Lillian Y Lim; Feiyan Liu; Rajan Jain; Li Li; Eric N Olson; Jonathan A Epstein
Journal:  Development       Date:  2015-08-07       Impact factor: 6.868

2.  Alternative Wnt Signaling Activates YAP/TAZ.

Authors:  Hyun Woo Park; Young Chul Kim; Bo Yu; Toshiro Moroishi; Jung-Soon Mo; Steven W Plouffe; Zhipeng Meng; Kimberly C Lin; Fa-Xing Yu; Caroline M Alexander; Cun-Yu Wang; Kun-Liang Guan
Journal:  Cell       Date:  2015-08-13       Impact factor: 41.582

3.  YAP promotes epithelial mesenchymal transition by upregulating Slug expression in human colorectal cancer cells.

Authors:  Dan Cheng; Lan Jin; Yunhe Chen; Xueyan Xi; Yang Guo
Journal:  Int J Clin Exp Pathol       Date:  2020-04-01

4.  Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells.

Authors:  Upal Basu-Roy; N Sumru Bayin; Kirk Rattanakorn; Eugenia Han; Dimitris G Placantonakis; Alka Mansukhani; Claudio Basilico
Journal:  Nat Commun       Date:  2015-04-02       Impact factor: 14.919

5.  Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ.

Authors:  Victoria Llado; Yuki Nakanishi; Angeles Duran; Miguel Reina-Campos; Phillip M Shelton; Juan F Linares; Tomoko Yajima; Alex Campos; Pedro Aza-Blanc; Michael Leitges; Maria T Diaz-Meco; Jorge Moscat
Journal:  Cell Rep       Date:  2015-02-05       Impact factor: 9.423

6.  AMOT130 linking F-actin to YAP is involved in intervertebral disc degeneration.

Authors:  Cong Zhang; Feng Wang; Zhiyang Xie; Lu Chen; Arjun Sinkemani; Haomin Yu; Xiaotao Wu
Journal:  Cell Prolif       Date:  2018-07-24       Impact factor: 6.831

7.  Targeting YAP Degradation by a Novel 1,2,4-Oxadiazole Derivative via Restoration of the Function of the Hippo Pathway.

Authors:  Eman M E Dokla; Chun-Sheng Fang; Po-Chen Chu; Chih-Shiang Chang; Khaled A M Abouzid; Ching S Chen
Journal:  ACS Med Chem Lett       Date:  2020-03-05       Impact factor: 4.345

8.  A role for the transducer of the Hippo pathway, TAZ, in the development of aggressive types of endometrial cancer.

Authors:  Laura Romero-Pérez; Pablo Garcia-Sanz; Alba Mota; Susanna Leskelä; Marta Hergueta-Redondo; Juan Díaz-Martín; M Angeles López-García; M Angeles Castilla; Angel Martínez-Ramírez; Robert A Soslow; Xavier Matias-Guiu; Gema Moreno-Bueno; Jose Palacios
Journal:  Mod Pathol       Date:  2015-09-18       Impact factor: 7.842

Review 9.  Transcriptional networks in the human epididymis.

Authors:  J A Browne; S-H Leir; S Yin; A Harris
Journal:  Andrology       Date:  2019-05-02       Impact factor: 3.842

10.  Monopolar spindle-one-binder protein 2 regulates the activity of large tumor suppressor/yes-associated protein to inhibit the motility of SMMC-7721 hepatocellular carcinoma cells.

Authors:  Weicheng Zhang; Jingyuan Shen; Fengming Gu; Ying Zhang; Wenjuan Wu; Jiachun Weng; Yuexia Liao; Zijing Deng; Qing Yuan; Lu Zheng; Yu Zhang; Weigan Shen
Journal:  Oncol Lett       Date:  2018-02-05       Impact factor: 2.967
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