Literature DB >> 26276632

Alternative Wnt Signaling Activates YAP/TAZ.

Hyun Woo Park1, Young Chul Kim2, Bo Yu3, Toshiro Moroishi1, Jung-Soon Mo1, Steven W Plouffe1, Zhipeng Meng1, Kimberly C Lin1, Fa-Xing Yu4, Caroline M Alexander5, Cun-Yu Wang3, Kun-Liang Guan6.   

Abstract

The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer. Here, we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3a induce YAP/TAZ activation independent of canonical Wnt/β-catenin signaling. Mechanistically, we delineate the "alternative Wnt-YAP/TAZ signaling axis" that consists of Wnt-FZD/ROR-Gα12/13-Rho GTPases-Lats1/2 to promote YAP/TAZ activation and TEAD-mediated transcription. YAP/TAZ mediate the biological functions of alternative Wnt signaling, including gene expression, osteogenic differentiation, cell migration, and antagonism of Wnt/β-catenin signaling. Together, our work establishes YAP/TAZ as critical mediators of alternative Wnt signaling.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26276632      PMCID： PMC4538707          DOI： 10.1016/j.cell.2015.07.013

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  67 in total

1.  New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening.

Authors:  Michael B Major; Brian S Roberts; Jason D Berndt; Shane Marine; Jamie Anastas; Namjin Chung; Marc Ferrer; XianHua Yi; Cristi L Stoick-Cooper; Priska D von Haller; Lorna Kategaya; Andy Chien; Stephane Angers; Michael MacCoss; Michele A Cleary; William T Arthur; Randall T Moon
Journal:  Sci Signal       Date:  2008-11-11       Impact factor: 8.192

2.  Wnt5b stimulates adipogenesis by activating PPARgamma, and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5a.

Authors:  F H J van Tienen; H Laeremans; C J H van der Kallen; H J M Smeets
Journal:  Biochem Biophys Res Commun       Date:  2009-07-03       Impact factor: 3.575

Review 3.  Wnt/beta-catenin signaling: components, mechanisms, and diseases.

Authors:  Bryan T MacDonald; Keiko Tamai; Xi He
Journal:  Dev Cell       Date:  2009-07       Impact factor: 12.270

4.  Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis.

Authors:  Bin Zhao; Li Li; Lloyd Wang; Cun-Yu Wang; Jindan Yu; Kun-Liang Guan
Journal:  Genes Dev       Date:  2012-01-01       Impact factor: 11.361

5.  Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.

Authors:  Yi Liu-Chittenden; Bo Huang; Joong Sup Shim; Qian Chen; Se-Jin Lee; Robert A Anders; Jun O Liu; Duojia Pan
Journal:  Genes Dev       Date:  2012-06-07       Impact factor: 11.361

6.  Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP.

Authors:  Eric Miller; Jiayi Yang; Michael DeRan; Chunlei Wu; Andrew I Su; Ghislain M C Bonamy; Jun Liu; Eric C Peters; Xu Wu
Journal:  Chem Biol       Date:  2012-08-09

7.  IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.

Authors:  Weidong Zhu; Ichiro Shiojima; Yuzuru Ito; Zhi Li; Hiroyuki Ikeda; Masashi Yoshida; Atsuhiko T Naito; Jun-ichiro Nishi; Hiroo Ueno; Akihiro Umezawa; Tohru Minamino; Toshio Nagai; Akira Kikuchi; Makoto Asashima; Issei Komuro
Journal:  Nature       Date:  2008-06-04       Impact factor: 49.962

8.  Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation.

Authors:  M R Byun; J-H Hwang; A R Kim; K M Kim; E S Hwang; M B Yaffe; J-H Hong
Journal:  Cell Death Differ       Date:  2014-02-07       Impact factor: 15.828

9.  Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.

Authors:  Fa-Xing Yu; Bin Zhao; Nattapon Panupinthu; Jenna L Jewell; Ian Lian; Lloyd H Wang; Jiagang Zhao; Haixin Yuan; Karen Tumaneng; Hairi Li; Xiang-Dong Fu; Gordon B Mills; Kun-Liang Guan
Journal:  Cell       Date:  2012-08-02       Impact factor: 41.582

10.  The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Authors:  Jordi Barretina; Giordano Caponigro; Nicolas Stransky; Kavitha Venkatesan; Adam A Margolin; Sungjoon Kim; Christopher J Wilson; Joseph Lehár; Gregory V Kryukov; Dmitriy Sonkin; Anupama Reddy; Manway Liu; Lauren Murray; Michael F Berger; John E Monahan; Paula Morais; Jodi Meltzer; Adam Korejwa; Judit Jané-Valbuena; Felipa A Mapa; Joseph Thibault; Eva Bric-Furlong; Pichai Raman; Aaron Shipway; Ingo H Engels; Jill Cheng; Guoying K Yu; Jianjun Yu; Peter Aspesi; Melanie de Silva; Kalpana Jagtap; Michael D Jones; Li Wang; Charles Hatton; Emanuele Palescandolo; Supriya Gupta; Scott Mahan; Carrie Sougnez; Robert C Onofrio; Ted Liefeld; Laura MacConaill; Wendy Winckler; Michael Reich; Nanxin Li; Jill P Mesirov; Stacey B Gabriel; Gad Getz; Kristin Ardlie; Vivien Chan; Vic E Myer; Barbara L Weber; Jeff Porter; Markus Warmuth; Peter Finan; Jennifer L Harris; Matthew Meyerson; Todd R Golub; Michael P Morrissey; William R Sellers; Robert Schlegel; Levi A Garraway
Journal:  Nature       Date:  2012-03-28       Impact factor: 49.962
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  253 in total

Review 1.  Gone Caving: Roles of the Transcriptional Regulators YAP and TAZ in Skeletal Development.

Authors:  Christopher D Kegelman; Joseph M Collins; Madhura P Nijsure; Emily A Eastburn; Joel D Boerckel
Journal:  Curr Osteoporos Rep       Date:  2020-10       Impact factor: 5.096

2.  UBTD1 is a mechano-regulator controlling cancer aggressiveness.

Authors:  Stéphanie Torrino; François-René Roustan; Lisa Kaminski; Thomas Bertero; Sabrina Pisano; Damien Ambrosetti; Maeva Dufies; Jay P Uhler; Emmanuel Lemichez; Amel Mettouchi; Maeva Gesson; Kathiane Laurent; Cedric Gaggioli; Jean-Francois Michiels; Christophe Lamaze; Frédéric Bost; Stéphan Clavel
Journal:  EMBO Rep       Date:  2019-02-25       Impact factor: 8.807

Review 3.  Biomechanical relationships between the corneal endothelium and Descemet's membrane.

Authors:  Maryam Ali; VijayKrishna Raghunathan; Jennifer Y Li; Christopher J Murphy; Sara M Thomasy
Journal:  Exp Eye Res       Date:  2016-09-14       Impact factor: 3.467

4.  Muscle Yap Is a Regulator of Neuromuscular Junction Formation and Regeneration.

Authors:  Kai Zhao; Chengyong Shen; Yisheng Lu; Zhihui Huang; Lei Li; Christopher D Rand; Jinxiu Pan; Xiang-Dong Sun; Zhibing Tan; Hongsheng Wang; Guanglin Xing; Yu Cao; Guoqing Hu; Jiliang Zhou; Wen-Cheng Xiong; Lin Mei
Journal:  J Neurosci       Date:  2017-02-17       Impact factor: 6.167

5.  YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma.

Authors:  Bo Tu; Jun Yao; Sammy Ferri-Borgogno; Jun Zhao; Shujuan Chen; Qiuyun Wang; Liang Yan; Xin Zhou; Cihui Zhu; Seungmin Bang; Qing Chang; Christopher A Bristow; Ya'an Kang; Hongwu Zheng; Huamin Wang; Jason B Fleming; Michael Kim; Timothy P Heffernan; Giulio F Draetta; Duojia Pan; Anirban Maitra; Wantong Yao; Sonal Gupta; Haoqiang Ying
Journal:  JCI Insight       Date:  2019-11-01

6.  Wnt/Yes-Associated Protein Interactions During Neural Tissue Patterning of Human Induced Pluripotent Stem Cells.

Authors:  Julie Bejoy; Liqing Song; Yi Zhou; Yan Li
Journal:  Tissue Eng Part A       Date:  2017-08-31       Impact factor: 3.845

Review 7.  Wnt signaling in cardiovascular disease: opportunities and challenges.

Authors:  Austin Gay; Dwight A Towler
Journal:  Curr Opin Lipidol       Date:  2017-10       Impact factor: 4.776

8.  Colon cancer stem cells: Potential target for the treatment of colorectal cancer.

Authors:  Riya Gupta; Lokesh Kumar Bhatt; Thomas P Johnston; Kedar S Prabhavalkar
Journal:  Cancer Biol Ther       Date:  2019-05-03       Impact factor: 4.742

Review 9.  Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).

Authors:  Pengfei Xu; Chiara Ianes; Fabian Gärtner; Congxing Liu; Timo Burster; Vasiliy Bakulev; Najma Rachidi; Uwe Knippschild; Joachim Bischof
Journal:  Gene       Date:  2019-07-31       Impact factor: 3.688

10.  YAP and TAZ Promote Periosteal Osteoblast Precursor Expansion and Differentiation for Fracture Repair.

Authors:  Christopher D Kegelman; Madhura P Nijsure; Yasaman Moharrer; Hope B Pearson; James H Dawahare; Kelsey M Jordan; Ling Qin; Joel D Boerckel
Journal:  J Bone Miner Res       Date:  2020-10-07       Impact factor: 6.741
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