Alan M Peaceman1, Yinglei Lai2, Dwight J Rouse3, Catherine Y Spong, Brian M Mercer4, Michael W Varner5, John M Thorp6, Susan M Ramin7, Fergal D Malone8, Mary J O'Sullivan9, Gary D V Hankins10. 1. Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. 2. Department of Obstetrics and Gynecology, The George Washington University Biostatistics Center, Washington, District of Columbia. 3. Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham Alabama. 4. Department of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio. 5. Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah. 6. Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 7. Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, Houston, Texas. 8. Department of Obstetrics and Gynecology, Columbia University, New York, New York. 9. Department of Obstetrics and Gynecology, University of Miami, Miami, Florida. 10. Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas.
Abstract
OBJECTIVE: The objective of the article is to describe latency for patients with preterm premature membrane rupture (PPROM) between 24(0/7) and 31(6/7) weeks' gestation. STUDY DESIGN: Secondary analysis of data collected prospectively in a multicenter clinical trial of magnesium sulfate for cerebral palsy prevention. Women with PPROM and fewer than six contractions per hour at enrollment who were candidates for expectant management (n = 1,377) were included in this analysis. Length of latency was calculated in days by subtracting the time of delivery from the time of membrane rupture. RESULTS: At each week of gestation, median latency between 24 and 28 weeks was similar at approximately 9 days, but it was significantly shorter with PPROM at 29, 30, and 31 weeks (p < 0.001). In addition, the percentage of patients remaining undelivered at 7 days and 14 days was similar for PPROM between 24 and 28 weeks, but it decreased significantly after that. For each gestational age, the proportion of patients remaining pregnant declined in a fashion similar to an exponential pattern. CONCLUSION: Median latency after PPROM is similar from 24 to 28 weeks' gestation, but it shortens with PPROM at and after 29 weeks. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: The objective of the article is to describe latency for patients with preterm premature membrane rupture (PPROM) between 24(0/7) and 31(6/7) weeks' gestation. STUDY DESIGN: Secondary analysis of data collected prospectively in a multicenter clinical trial of magnesium sulfate for cerebral palsy prevention. Women with PPROM and fewer than six contractions per hour at enrollment who were candidates for expectant management (n = 1,377) were included in this analysis. Length of latency was calculated in days by subtracting the time of delivery from the time of membrane rupture. RESULTS: At each week of gestation, median latency between 24 and 28 weeks was similar at approximately 9 days, but it was significantly shorter with PPROM at 29, 30, and 31 weeks (p < 0.001). In addition, the percentage of patients remaining undelivered at 7 days and 14 days was similar for PPROM between 24 and 28 weeks, but it decreased significantly after that. For each gestational age, the proportion of patients remaining pregnant declined in a fashion similar to an exponential pattern. CONCLUSION: Median latency after PPROM is similar from 24 to 28 weeks' gestation, but it shortens with PPROM at and after 29 weeks. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: J C Carey; M A Klebanoff; J C Hauth; S L Hillier; E A Thom; J M Ernest; R P Heine; R P Nugent; M L Fischer; K J Leveno; R Wapner; M Varner Journal: N Engl J Med Date: 2000-02-24 Impact factor: 91.245
Authors: Dwight J Rouse; Deborah G Hirtz; Elizabeth Thom; Michael W Varner; Catherine Y Spong; Brian M Mercer; Jay D Iams; Ronald J Wapner; Yoram Sorokin; James M Alexander; Margaret Harper; John M Thorp; Susan M Ramin; Fergal D Malone; Marshall Carpenter; Menachem Miodovnik; Atef Moawad; Mary J O'Sullivan; Alan M Peaceman; Gary D V Hankins; Oded Langer; Steve N Caritis; James M Roberts Journal: N Engl J Med Date: 2008-08-28 Impact factor: 91.245
Authors: Richard G Brown; Julian R Marchesi; Yun S Lee; Ann Smith; Benjamin Lehne; Lindsay M Kindinger; Vasso Terzidou; Elaine Holmes; Jeremy K Nicholson; Phillip R Bennett; David A MacIntyre Journal: BMC Med Date: 2018-01-24 Impact factor: 8.775
Authors: Angela J Stephens; John R Barton; Nana-Ama Ankumah Bentum; Sean C Blackwell; Baha M Sibai Journal: Am J Perinatol Date: 2020-04-28 Impact factor: 1.862
Authors: Richard G Brown; Maya Al-Memar; Julian R Marchesi; Yun S Lee; Ann Smith; Denise Chan; Holly Lewis; Lindsay Kindinger; Vasso Terzidou; Tom Bourne; Phillip R Bennett; David A MacIntyre Journal: Transl Res Date: 2018-12-27 Impact factor: 7.012