OBJECTIVE: Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of prematurity. We hypothesized that, when controlled for delivery gestational age, potential prolonged exposure to inflammation/infection could be harmful to the developing fetus. STUDY DESIGN: We studied a retrospective cohort of pregnancies with PPROM at 22.0-33.9 weeks' gestation. The primary outcome was perinatal survival without major morbidity (grade III/IV intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia). Regression models assessed predictors of perinatal morbidity. RESULTS: Three hundred six women were included. PPROM occurred at a median of 29.4 weeks' gestation (interquartile range [IQR], 24.7-32.1 weeks' gestation). Median latency was 8 days (IQR, 3-15 days). Median delivery age was 31.4 weeks' gestation (IQR, 27.4-33.3 weeks' gestation). Two hundred seventy-seven infants (91%) survived; 233 infants (84% of survivors, 76% of all babies) did not have major morbidities. Gestational age (odds ratio, 0.60; 95% confidence interval, 0.53-0.68) and congenital sepsis (odds ratio, 13.2; 95% confidence interval, 3.9-44.5), but not latency, predicted perinatal morbidity in multivariate models. CONCLUSION: Latency does not appear to worsen outcomes in pregnancies that are complicated by PPROM.
OBJECTIVE: Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of prematurity. We hypothesized that, when controlled for delivery gestational age, potential prolonged exposure to inflammation/infection could be harmful to the developing fetus. STUDY DESIGN: We studied a retrospective cohort of pregnancies with PPROM at 22.0-33.9 weeks' gestation. The primary outcome was perinatal survival without major morbidity (grade III/IV intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia). Regression models assessed predictors of perinatal morbidity. RESULTS: Three hundred six women were included. PPROM occurred at a median of 29.4 weeks' gestation (interquartile range [IQR], 24.7-32.1 weeks' gestation). Median latency was 8 days (IQR, 3-15 days). Median delivery age was 31.4 weeks' gestation (IQR, 27.4-33.3 weeks' gestation). Two hundred seventy-seven infants (91%) survived; 233 infants (84% of survivors, 76% of all babies) did not have major morbidities. Gestational age (odds ratio, 0.60; 95% confidence interval, 0.53-0.68) and congenital sepsis (odds ratio, 13.2; 95% confidence interval, 3.9-44.5), but not latency, predicted perinatal morbidity in multivariate models. CONCLUSION: Latency does not appear to worsen outcomes in pregnancies that are complicated by PPROM.
Authors: Alan M Peaceman; Yinglei Lai; Dwight J Rouse; Catherine Y Spong; Brian M Mercer; Michael W Varner; John M Thorp; Susan M Ramin; Fergal D Malone; Mary J O'Sullivan; Gary D V Hankins Journal: Am J Perinatol Date: 2014-05-12 Impact factor: 1.862
Authors: Luchin F Wong; Calla M Holmgren; Robert M Silver; Michael W Varner; Tracy A Manuck Journal: Am J Obstet Gynecol Date: 2014-09-16 Impact factor: 8.661
Authors: Ernesto González-Mesa; Marta Blasco-Alonso; María José Benítez; Cristina Gómez-Muñoz; Lorena Sabonet-Morente; Manuel Gómez-Castellanos; Osmayda Ulloa; Ernesto González-Cazorla; Alberto Puertas-Prieto; Juan Mozas-Moreno; Jesús Jiménez-López; Daniel Lubián-López Journal: Medicina (Kaunas) Date: 2021-05-11 Impact factor: 2.430