PURPOSE: To evaluate and compare the diagnostic value of T1 , T2 * relaxation times and off-resonance saturation ratios (OSR) in healthy controls and patients with different clinical and morphological stages of Achilles tendinopathy. MATERIAL AND METHODS: Forty-two healthy Achilles tendons and 34 tendons of 17 patients with symptomatic and asymptomatic tendinopathy were investigated clinically with conventional magnetic resonance imaging (MRI) sequences on a 3T whole-body MR scanner and a dynamic ultrasound examination. In addition, T1 and T2 * relaxation times were assessed using an ultrashort echo time (UTE) imaging sequence with flip angle and echo time variation. For the calculation of OSR values a Gaussian off-resonance saturation pulse (frequency offset: 750-5000 Hz) was used. The diagnostic value of the derived MR values was assessed and compared using receiver operating characteristic (ROC) curves. RESULTS: ROC curves demonstrate the highest overall test performance for OSR values at 2000 Hz off-resonance in differentiating slightly (OSR-2000 [AUC: 0.930] > T2 * [AUC: 0.884] > T1 [AUC: 0.737]) and more severe pathologically altered tendon areas (OSR-2000 [AUC: 0.964] > T2 * [AUC: 0.917] > T1 [AUC: 0.819]) from healthy ones. CONCLUSION: OSR values at a frequency offset of 2000 Hz demonstrated a better sensitivity and specificity for detecting mild and severe stages of tendinopathy compared to T2 * and particularly when compared to T1 relaxation times.
PURPOSE: To evaluate and compare the diagnostic value of T1 , T2 * relaxation times and off-resonance saturation ratios (OSR) in healthy controls and patients with different clinical and morphological stages of Achilles tendinopathy. MATERIAL AND METHODS: Forty-two healthy Achilles tendons and 34 tendons of 17 patients with symptomatic and asymptomatic tendinopathy were investigated clinically with conventional magnetic resonance imaging (MRI) sequences on a 3T whole-body MR scanner and a dynamic ultrasound examination. In addition, T1 and T2 * relaxation times were assessed using an ultrashort echo time (UTE) imaging sequence with flip angle and echo time variation. For the calculation of OSR values a Gaussian off-resonance saturation pulse (frequency offset: 750-5000 Hz) was used. The diagnostic value of the derived MR values was assessed and compared using receiver operating characteristic (ROC) curves. RESULTS: ROC curves demonstrate the highest overall test performance for OSR values at 2000 Hz off-resonance in differentiating slightly (OSR-2000 [AUC: 0.930] > T2 * [AUC: 0.884] > T1 [AUC: 0.737]) and more severe pathologically altered tendon areas (OSR-2000 [AUC: 0.964] > T2 * [AUC: 0.917] > T1 [AUC: 0.819]) from healthy ones. CONCLUSION: OSR values at a frequency offset of 2000 Hz demonstrated a better sensitivity and specificity for detecting mild and severe stages of tendinopathy compared to T2 * and particularly when compared to T1 relaxation times.
Authors: Hyungseok Jang; Annette von Drygalski; Jonathan Wong; Jenny Y Zhou; Peter Aguero; Xing Lu; Xin Cheng; Scott T Ball; Yajun Ma; Eric Y Chang; Jiang Du Journal: Magn Reson Med Date: 2020-07-14 Impact factor: 4.668
Authors: Hyungseok Jang; Alan B McMillan; Yajun Ma; Saeed Jerban; Eric Y Chang; Jiang Du; Richard Kijowski Journal: NMR Biomed Date: 2020-08-05 Impact factor: 4.044
Authors: Eric Y Chang; Won C Bae; Hongda Shao; Reni Biswas; Shihong Li; Jun Chen; Shantanu Patil; Robert Healey; Darryl D D'Lima; Christine B Chung; Jiang Du Journal: NMR Biomed Date: 2015-05-18 Impact factor: 4.044
Authors: Lena Marie Wilms; Karl Ludger Radke; David Latz; Thomas Andreas Thiel; Miriam Frenken; Benedikt Kamp; Timm Joachim Filler; Armin Michael Nagel; Anja Müller-Lutz; Daniel Benjamin Abrar; Sven Nebelung Journal: Quant Imaging Med Surg Date: 2022-08