Literature DB >> 24809302

Proactive approach to lymphedema risk reduction: a prospective study.

Mei R Fu1, Deborah Axelrod, Amber A Guth, Francis Cartwright, Zeyuan Qiu, Judith D Goldberg, June Kim, Joan Scagliola, Robin Kleinman, Judith Haber.   

Abstract

BACKGROUND: Advances in cancer treatments continue to reduce the incidence of lymphedema. Yet, many breast cancer survivors still face long-term postoperative challenges as a result of developing lymphedema. The purpose of this study was to preliminarily evaluate The Optimal Lymph Flow program, a patient-centered education and behavioral program focusing on self-care strategies to enhance lymphedema risk reduction by promoting lymph flow and optimize body mass index (BMI).
METHODS: A prospective, longitudinal, quasi-experimental design with repeated-measures was used. The study outcomes included lymph volume changes by infrared perometer, and BMI by a bioimpedance device at pre-surgery baseline, 2-4 weeks after surgery, 6-month and 12-month follow-up. A total of 140 patients were recruited and participated in The Optimal Lymph Flow program; 134 patients completed the study with 4 % attrition rate.
RESULTS: Fifty-eight percent of patients had axillary node dissection and 42 % had sentinel lymph node biopsy (SLNB). The majority (97 %) of patients maintained and improved their preoperative limb volume (LV) and BMI at the study endpoint of 12 months following cancer surgery. Cumulatively, two patients with SLNB and two patients with axillary lymph node dissection had measurable lymphedema (>10 % LV change). At the 12-month follow-up, among the four patients with measurable lymphedema, two patients' LV returned to preoperative level without compression therapy but by maintaining The Optimal Lymph Flow exercises to promote daily lymph flow.
CONCLUSIONS: This educational and behavioral program is effective in enhancing lymphedema risk reduction. The study provided initial evidence for emerging change in lymphedema care from treatment-focus to proactive risk reduction.

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Year:  2014        PMID: 24809302      PMCID: PMC4163073          DOI: 10.1245/s10434-014-3761-z

Source DB:  PubMed          Journal:  Ann Surg Oncol        ISSN: 1068-9265            Impact factor:   5.344


  20 in total

Review 1.  The diagnosis and treatment of peripheral lymphedema. Consensus document of the International Society of Lymphology.

Authors: 
Journal:  Lymphology       Date:  2003-06       Impact factor: 1.286

2.  Risk factors for lymphedema in a prospective breast cancer survivorship study: the Pathways Study.

Authors:  Marilyn L Kwan; Jeanne Darbinian; Kathryn H Schmitz; Rebecca Citron; Paula Partee; Susan E Kutner; Lawrence H Kushi
Journal:  Arch Surg       Date:  2010-11

3.  A comparison of four diagnostic criteria for lymphedema in a post-breast cancer population.

Authors:  Jane M Armer; Bob R Stewart
Journal:  Lymphat Res Biol       Date:  2005       Impact factor: 2.589

Review 4.  A systematic review of the evidence for complete decongestive therapy in the treatment of lymphedema from 2004 to 2011.

Authors:  Bonnie B Lasinski; Kathryn McKillip Thrift; Decourcy Squire; Melanie K Austin; Kandis M Smith; Ausanee Wanchai; Jason M Green; Bob R Stewart; Janice N Cormier; Jane M Armer
Journal:  PM R       Date:  2012-08       Impact factor: 2.298

5.  The effect of providing information about lymphedema on the cognitive and symptom outcomes of breast cancer survivors.

Authors:  Mei R Fu; Constance M Chen; Judith Haber; Amber A Guth; Deborah Axelrod
Journal:  Ann Surg Oncol       Date:  2010-02-06       Impact factor: 5.344

Review 6.  Preventative measures for lymphedema: separating fact from fiction.

Authors:  Yeliz Cemal; Andrea Pusic; Babak J Mehrara
Journal:  J Am Coll Surg       Date:  2011-07-28       Impact factor: 6.113

Review 7.  A prospective surveillance model for rehabilitation for women with breast cancer.

Authors:  Nicole L Stout; Jill M Binkley; Kathryn H Schmitz; Kimberly Andrews; Sandra C Hayes; Kristin L Campbell; Margaret L McNeely; Peter W Soballe; Ann M Berger; Andrea L Cheville; Carol Fabian; Lynn H Gerber; Susan R Harris; Karin Johansson; Andrea L Pusic; Robert G Prosnitz; Robert A Smith
Journal:  Cancer       Date:  2012-04-15       Impact factor: 6.860

Review 8.  Lymphedema: an immunologically vulnerable site for development of neoplasms.

Authors:  Vincenzo Ruocco; Robert A Schwartz; Eleonora Ruocco
Journal:  J Am Acad Dermatol       Date:  2002-07       Impact factor: 11.527

9.  Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: objective measurements.

Authors:  Sarah A McLaughlin; Mary J Wright; Katherine T Morris; Gladys L Giron; Michelle R Sampson; Julia P Brockway; Karen E Hurley; Elyn R Riedel; Kimberly J Van Zee
Journal:  J Clin Oncol       Date:  2008-10-06       Impact factor: 44.544

10.  Predictors of lymphedema in patients with breast cancer undergoing axillary lymph node dissection in Hong Kong.

Authors:  So Shan Mak; Winnie Yeo; Yik Mun Lee; Kwok Fai Mo; Ka Yin Tse; Sut Mun Tse; Fung Ping Ho; Wing Hong Kwan
Journal:  Nurs Res       Date:  2008 Nov-Dec       Impact factor: 2.381

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  18 in total

1.  Development of a Mobile-Based Self-care Application for Patients with Breast Cancer-Related Lymphedema in Iran.

Authors:  Maryam Ahmadi; Seyedeh Nafiseh Shahrokhi; Morteza Khavaninzadeh; Jahanpour Alipour
Journal:  Appl Clin Inform       Date:  2022-10-05       Impact factor: 2.762

Review 2.  The Effects of Exercise-Based Interventions on Fluid Overload Symptoms in Patients with Heart Failure: A Systematic Review and Meta-Analysis.

Authors:  Mei Rosemary Fu; Yuan Li; Catherine Conway; Alessandra Masone; Jinbo Fang; Christopher Lee
Journal:  Biomedicines       Date:  2022-05-11

3.  Kinect-Based In-Home Exercise System for Lymphatic Health and Lymphedema Intervention.

Authors:  An-Ti Chiang; Qi Chen; Yao Wang; Mei R Fu
Journal:  IEEE J Transl Eng Health Med       Date:  2018-10-12       Impact factor: 3.316

4.  Precision assessment of heterogeneity of lymphedema phenotype, genotypes and risk prediction.

Authors:  Mei R Fu; Yvette P Conley; Deborah Axelrod; Amber A Guth; Gary Yu; Jason Fletcher; David Zagzag
Journal:  Breast       Date:  2016-07-22       Impact factor: 4.380

5.  mHealth self-care interventions: managing symptoms following breast cancer treatment.

Authors:  Mei R Fu; Deborah Axelrod; Amber A Guth; Kavita Rampertaap; Nardin El-Shammaa; Karen Hiotis; Joan Scagliola; Gary Yu; Yao Wang
Journal:  Mhealth       Date:  2016-07-22

6.  Motion Sequence Alignment for A Kinect-Based In-Home Exercise System for Lymphatic Health and Lymphedema Intervention.

Authors:  An-Ti Chiang; Qi Chen; Yao Wang; Mei R Fu
Journal:  Annu Int Conf IEEE Eng Med Biol Soc       Date:  2018-07

7.  Real-time electronic patient evaluation of lymphedema symptoms, referral, and satisfaction: a cross-sectional study.

Authors:  Jennifer L Nahum; Mei R Fu; Joan Scagliola; Martha Rodorigo; Sandy Tobik; Amber Guth; Deborah Axelrod
Journal:  Mhealth       Date:  2021-04-20

8.  Machine learning for detection of lymphedema among breast cancer survivors.

Authors:  Mei R Fu; Yao Wang; Chenge Li; Zeyuan Qiu; Deborah Axelrod; Amber A Guth; Joan Scagliola; Yvette Conley; Bradley E Aouizerat; Jeanna M Qiu; Gary Yu; Janet H Van Cleave; Judith Haber; Ying Kuen Cheung
Journal:  Mhealth       Date:  2018-05-29

9.  Limb Volume Changes and Activities of Daily Living: A Prospective Study.

Authors:  Jae Hyung Park; John Merriman; Abraham Brody; Jason Fletcher; Gary Yu; Eunjung Ko; Alejandra Yancey; Mei R Fu
Journal:  Lymphat Res Biol       Date:  2020-11-13       Impact factor: 2.349

10.  Model-Based Patterns of Lymphedema Symptomatology: Phenotypic and Biomarker Characterization.

Authors:  Mei R Fu; Bradley E Aouizerat; Gary Yu; Yvette Conley; Deborah Axelrod; Amber A Guth; Jean-Pierre Gagner; Jeanna M Qiu; David Zagzag
Journal:  Curr Breast Cancer Rep       Date:  2020-11-24
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