Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ribonucleotides in DNA: origins, repair and consequences.

Literature DB >> 24794402

Ribonucleotides in DNA: origins, repair and consequences.

Abstract

While primordial life is thought to have been RNA-based (Cech, Cold Spring Harbor Perspect. Biol. 4 (2012) a006742), all living organisms store genetic information in DNA, which is chemically more stable. Distinctions between the RNA and DNA worlds and our views of "DNA" synthesis continue to evolve as new details emerge on the incorporation, repair and biological effects of ribonucleotides in DNA genomes of organisms from bacteria through humans. Published by Elsevier B.V.

Entities: Chemical Disease Gene Mutation Species

Keywords: DNA polymerase; DNA repair; DNA replication; Genome instability; Ribonucleotides

Mesh：

Substances：

Year: 2014 PMID： 24794402 PMCID： PMC4065383 DOI： 10.1016/j.dnarep.2014.03.029

Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856

104 in total

1. A single 2'-hydroxyl group converts B-DNA to A-DNA. Crystal structure of the DNA-RNA chimeric decamer duplex d(CCGGC)r(G)d(CCGG) with a novel intermolecular G-C base-paired quadruplet.

Authors: C Ban; B Ramakrishnan; M Sundaralingam
Journal: J Mol Biol Date: 1994-02-11 Impact factor: 5.469

2. The presence of RNA in a double helix inhibits its interaction with histone protein.

Authors: K Dunn; J D Griffith
Journal: Nucleic Acids Res Date: 1980-02-11 Impact factor: 16.971

3. Substrate specificity of human RNase H1 and its role in excision repair of ribose residues misincorporated in DNA.

Authors: P S Eder; R Y Walder; J A Walder
Journal: Biochimie Date: 1993 Impact factor: 4.079

4. Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations.

Authors: A Aguilera; H L Klein
Journal: Genetics Date: 1988-08 Impact factor: 4.562

Review 5. Physiological concentrations of purines and pyrimidines.

Authors: T W Traut
Journal: Mol Cell Biochem Date: 1994-11-09 Impact factor: 3.396

6. Conformational influence of the ribose 2'-hydroxyl group: crystal structures of DNA-RNA chimeric duplexes.

Authors: M Egli; N Usman; A Rich
Journal: Biochemistry Date: 1993-04-06 Impact factor: 3.162

7. Structural influence of RNA incorporation in DNA: quantitative nuclear magnetic resonance refinement of d(CG)r(CG)d(CG) and d(CG)r(C)d(TAGCG).

Authors: T N Jaishree; G A van der Marel; J H van Boom; A H Wang
Journal: Biochemistry Date: 1993-05-11 Impact factor: 3.162

8. Formation of ribonucleotides in DNA modified by oxidative damage in vitro and in vivo. Characterization by 32P-postlabeling.

Authors: K Randerath; R Reddy; T F Danna; W P Watson; A E Crane; E Randerath
Journal: Mutat Res Date: 1992-09 Impact factor: 2.433

Ribonucleotides in DNA: origins, repair and consequences.

1. A single 2'-hydroxyl group converts B-DNA to A-DNA. Crystal structure of the DNA-RNA chimeric decamer duplex d(CCGGC)r(G)d(CCGG) with a novel intermolecular G-C base-paired quadruplet.

2. The presence of RNA in a double helix inhibits its interaction with histone protein.

3. Substrate specificity of human RNase H1 and its role in excision repair of ribose residues misincorporated in DNA.

4. Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations.

Review 5. Physiological concentrations of purines and pyrimidines.

6. Conformational influence of the ribose 2'-hydroxyl group: crystal structures of DNA-RNA chimeric duplexes.

7. Structural influence of RNA incorporation in DNA: quantitative nuclear magnetic resonance refinement of d(CG)r(CG)d(CG) and d(CG)r(C)d(TAGCG).

8. Formation of ribonucleotides in DNA modified by oxidative damage in vitro and in vivo. Characterization by 32P-postlabeling.

9. Saccharomyces cerevisiae tRNA ligase. Purification of the protein and isolation of the structural gene.

10. Ribonucleotide-induced helical alteration in DNA prevents nucleosome formation.

1. Stimulation of Chromosomal Rearrangements by Ribonucleotides.

2. Effects of neutral salts and pH on the activity and stability of human RNase H2.

3. Impact of template backbone heterogeneity on RNA polymerase II transcription.

4. RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair.

Review 5. New insights and challenges in mismatch repair: getting over the chromatin hurdle.

Review 6. Base excision repair capacity in informing healthspan.

Review 7. Nucleotide excision repair in humans.

8. Measuring ribonucleotide incorporation into DNA in vitro and in vivo.

9. Why are Hoogsteen base pairs energetically disfavored in A-RNA compared to B-DNA?

10. Analysis of Ribonucleotide Removal from DNA by Human Nucleotide Excision Repair.