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Literature DB >> 24791224

DNA Aptamer Technology for Personalized Medicine.

Hang Xing¹, Kevin Hwang², Ji Li¹, Seyed-Fakhreddin Torabi³, Yi Lu⁴.

Abstract

This review highlights recent progress in developing DNA aptamers for personalized medicine, with more focus on in vivo studies for potential clinical applications. Examples include design of aptamers in combination with DNA nanostructures, nanomaterials, or microfluidic devices as diagnostic probes or therapeutic agents for cancers and other diseases. The use of aptamers as targeting agents in drug delivery is also covered. The advantages and future directions of such DNA aptamer-based technology for the continued development of personalized medicine are discussed.

Entities: CellLine Chemical Disease Gene Species

Keywords: DNA aptamer; cancer; diagnosis; personalized medicine; targeted delivery; therapy

Year: 2014 PMID： 24791224 PMCID： PMC4001932 DOI： 10.1016/j.coche.2014.01.007

Source DB: PubMed Journal: Curr Opin Chem Eng ISSN： 2211-3398 Impact factor: 5.163

59 in total

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Authors: A A Beaudry; G F Joyce
Journal: Science Date: 1992-07-31 Impact factor: 47.728

2. Multivalent DNA nanospheres for enhanced capture of cancer cells in microfluidic devices.

Authors: Weian Sheng; Tao Chen; Weihong Tan; Z Hugh Fan
Journal: ACS Nano Date: 2013-07-15 Impact factor: 15.881

Review 3. The application of aptamers in cancer research: an up-to-date review.

Authors: Meidi Hu; Kunhe Zhang
Journal: Future Oncol Date: 2013-03 Impact factor: 3.404

4. Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets.

Authors: Yu Xiang; Yi Lu
Journal: Nat Chem Date: 2011-07-24 Impact factor: 24.427

Review 5. DNA aptamer functionalized nanomaterials for intracellular analysis, cancer cell imaging and drug delivery.

Authors: Hang Xing; Ngo Yin Wong; Yu Xiang; Yi Lu
Journal: Curr Opin Chem Biol Date: 2012-04-26 Impact factor: 8.822

6. Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery.

Authors: Jianwei Guo; Xiaoling Gao; Lina Su; Huimin Xia; Guangzhi Gu; Zhiqing Pang; Xinguo Jiang; Lei Yao; Jun Chen; Hongzhuan Chen
Journal: Biomaterials Date: 2011-07-23 Impact factor: 12.479

7. The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells.

Authors: Sridharan Soundararajan; Weiwei Chen; Eleanor K Spicer; Nigel Courtenay-Luck; Daniel J Fernandes
Journal: Cancer Res Date: 2008-04-01 Impact factor: 12.701

8. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Authors: Arun Sreekumar; Laila M Poisson; Thekkelnaycke M Rajendiran; Amjad P Khan; Qi Cao; Jindan Yu; Bharathi Laxman; Rohit Mehra; Robert J Lonigro; Yong Li; Mukesh K Nyati; Aarif Ahsan; Shanker Kalyana-Sundaram; Bo Han; Xuhong Cao; Jaeman Byun; Gilbert S Omenn; Debashis Ghosh; Subramaniam Pennathur; Danny C Alexander; Alvin Berger; Jeffrey R Shuster; John T Wei; Sooryanarayana Varambally; Christopher Beecher; Arul M Chinnaiyan
Journal: Nature Date: 2009-02-12 Impact factor: 49.962

9. CS-SELEX generates high-affinity ssDNA aptamers as molecular probes for hepatitis C virus envelope glycoprotein E2.

Authors: Fang Chen; Yilan Hu; Dongqing Li; Haidan Chen; Xiao-Lian Zhang
Journal: PLoS One Date: 2009-12-03 Impact factor: 3.240

10. Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors.

Authors: Li Tang; Xujuan Yang; Lawrence W Dobrucki; Isthier Chaudhury; Qian Yin; Catherine Yao; Stéphane Lezmi; William G Helferich; Timothy M Fan; Jianjun Cheng
Journal: Angew Chem Int Ed Engl Date: 2012-11-07 Impact factor: 15.336

12 in total

Review 1. Recent advances in understanding oligonucleotide aptamers and their applications as therapeutic agents.

Authors: Khaled S Allemailem; Ahmad Almatroudi; Mohammed A Alsahli; Ghaiyda Talal Basfar; Faris Alrumaihi; Arshad Husain Rahmani; Amjad Ali Khan
Journal: 3 Biotech Date: 2020-11-24 Impact factor: 2.406

Review 2. Metal-Dependent DNAzymes for the Quantitative Detection of Metal Ions in Living Cells: Recent Progress, Current Challenges, and Latest Results on FRET Ratiometric Sensors.

Authors: Kevin Hwang; Quanbing Mou; Ryan J Lake; Mengyi Xiong; Brandalynn Holland; Yi Lu
Journal: Inorg Chem Date: 2019-07-31 Impact factor: 5.165

Review 3. Peptide aptamers: development and applications.

Authors: Sergey Reverdatto; David S Burz; Alexander Shekhtman
Journal: Curr Top Med Chem Date: 2015 Impact factor: 3.295

4. Oligonucleotide aptamer-drug conjugates for targeted therapy of acute myeloid leukemia.

Authors: Nianxi Zhao; Sung-Nan Pei; Jianjun Qi; Zihua Zeng; Swaminathan P Iyer; Pei Lin; Ching-Hsuan Tung; Youli Zu
Journal: Biomaterials Date: 2015-07-15 Impact factor: 12.479

Review 5. Overcoming Major Barriers to Developing Successful Sensors for Practical Applications Using Functional Nucleic Acids.

Authors: JingJing Zhang; Tian Lan; Yi Lu
Journal: Annu Rev Anal Chem (Palo Alto Calif) Date: 2022-02-25 Impact factor: 12.400

Review 6. Applications of synchrotron-based spectroscopic techniques in studying nucleic acids and nucleic acid-functionalized nanomaterials.

Authors: Peiwen Wu; Yang Yu; Claire E McGhee; Li Huey Tan; Yi Lu
Journal: Adv Mater Date: 2014-09-10 Impact factor: 30.849