A Burgetova1, P Dusek2,3, M Vaneckova4, D Horakova2, C Langkammer5, J Krasensky4, L Sobisek6, P Matras4, M Masek4, Z Seidl4. 1. From the Departments of Radiology (A.B., M.V., J.K., P.M., M.M., Z.S.) andrea.burgetova@vfn.cz. 2. Neurology (P.D., D.H.), Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. 3. Institute of Neuroradiology (P.D.), University Medicine Göttingen, Göttingen, Germany. 4. From the Departments of Radiology (A.B., M.V., J.K., P.M., M.M., Z.S.). 5. Department of Neurology (C.L.), Medical University of Graz, Graz, Austria. 6. Department of Statistics and Probability (L.S.), University of Economics, Prague, Czech Republic.
Abstract
BACKGROUND AND PURPOSE: Potential differences between primary progressive and relapsing remitting multiple sclerosis are the subject of ongoing controversial discussions. The aim of this work was to determine whether and how primary-progressive and relapsing-remitting multiple sclerosis subtypes differ regarding conventional MR imaging parameters, cerebral iron deposits, and their association with clinical status. MATERIALS AND METHODS: We analyzed 24 patients with primary-progressive MS, 80 with relapsing-remitting MS, and 20 healthy controls with 1.5T MR imaging for assessment of the conventional quantitative parameters: T2 lesion load, T1 lesion load, brain parenchymal fraction, and corpus callosum volume. Quantitative susceptibility mapping was performed to estimate iron concentration in the deep gray matter. RESULTS: Decreased susceptibility within the thalamus in relapsing-remitting MS compared with primary-progressive MS was the only significant MR imaging difference between these MS subtypes. In the relapsing-remitting MS subgroup, the Expanded Disability Status Scale score was positively associated with conventional parameters reflecting white matter lesions and brain atrophy and with iron in the putamen and caudate nucleus. A positive association with putaminal iron and the Expanded Disability Status Scale score was found in primary-progressive MS. CONCLUSIONS: Susceptibility in the thalamus might provide additional support for the differentiation between primary-progressive and relapsing-remitting MS. That the Expanded Disability Status Scale score was associated with conventional MR imaging parameters and iron concentrations in several deep gray matter regions in relapsing-remitting MS, while only a weak association with putaminal iron was observed in primary-progressive MS suggests different driving forces of disability in these MS subtypes.
BACKGROUND AND PURPOSE: Potential differences between primary progressive and relapsing remitting multiple sclerosis are the subject of ongoing controversial discussions. The aim of this work was to determine whether and how primary-progressive and relapsing-remitting multiple sclerosis subtypes differ regarding conventional MR imaging parameters, cerebral iron deposits, and their association with clinical status. MATERIALS AND METHODS: We analyzed 24 patients with primary-progressive MS, 80 with relapsing-remitting MS, and 20 healthy controls with 1.5T MR imaging for assessment of the conventional quantitative parameters: T2 lesion load, T1 lesion load, brain parenchymal fraction, and corpus callosum volume. Quantitative susceptibility mapping was performed to estimate iron concentration in the deep gray matter. RESULTS: Decreased susceptibility within the thalamus in relapsing-remitting MS compared with primary-progressive MS was the only significant MR imaging difference between these MS subtypes. In the relapsing-remitting MS subgroup, the Expanded Disability Status Scale score was positively associated with conventional parameters reflecting white matter lesions and brain atrophy and with iron in the putamen and caudate nucleus. A positive association with putaminal iron and the Expanded Disability Status Scale score was found in primary-progressive MS. CONCLUSIONS: Susceptibility in the thalamus might provide additional support for the differentiation between primary-progressive and relapsing-remitting MS. That the Expanded Disability Status Scale score was associated with conventional MR imaging parameters and iron concentrations in several deep gray matter regions in relapsing-remitting MS, while only a weak association with putaminal iron was observed in primary-progressive MS suggests different driving forces of disability in these MS subtypes.
Authors: Michael Khalil; Christian Langkammer; Alexander Pichler; Daniela Pinter; Thomas Gattringer; Gerhard Bachmaier; Stefan Ropele; Siegrid Fuchs; Christian Enzinger; Franz Fazekas Journal: Neurology Date: 2015-05-15 Impact factor: 9.910
Authors: L Truyen; J H van Waesberghe; M A van Walderveen; B W van Oosten; C H Polman; O R Hommes; H J Adèr; F Barkhof Journal: Neurology Date: 1996-12 Impact factor: 9.910
Authors: Stefan Ropele; Iris D Kilsdonk; Mike P Wattjes; Christian Langkammer; Wolter L de Graaf; Jette L Frederiksen; Henrik B Larsson; Marios Yiannakas; Claudia Am Wheeler-Kingshott; Christian Enzinger; Michael Khalil; Maria A Rocca; Till Sprenger; Michael Amann; Ludwig Kappos; Massimo Filippi; Alex Rovira; Olga Ciccarelli; Frederik Barkhof; Franz Fazekas Journal: Mult Scler Date: 2014-04-30 Impact factor: 6.312
Authors: Eytan Raz; Brittany Branson; Jens H Jensen; Maxim Bester; James S Babb; Joseph Herbert; Robert I Grossman; Matilde Inglese Journal: J Neurol Date: 2014-11-22 Impact factor: 4.849
Authors: Carol Di Perri; Marco Battaglini; Maria L Stromillo; Maria L Bartolozzi; Leonello Guidi; Antonio Federico; Nicola De Stefano Journal: Arch Neurol Date: 2008-02
Authors: M Khalil; C Langkammer; S Ropele; K Petrovic; M Wallner-Blazek; M Loitfelder; M Jehna; G Bachmaier; R Schmidt; C Enzinger; S Fuchs; F Fazekas Journal: Neurology Date: 2011-10-05 Impact factor: 9.910
Authors: Tomas Kalincik; Manuela Vaneckova; Michaela Tyblova; Jan Krasensky; Zdenek Seidl; Eva Havrdova; Dana Horakova Journal: PLoS One Date: 2012-11-15 Impact factor: 3.240
Authors: G Pontillo; S Cocozza; R Lanzillo; C Russo; M D Stasi; C Paolella; E A Vola; C Criscuolo; P Borrelli; G Palma; E Tedeschi; V B Morra; A Elefante; A Brunetti Journal: AJNR Am J Neuroradiol Date: 2018-12-20 Impact factor: 3.825
Authors: Romana Burgetova; Petr Dusek; Andrea Burgetova; Adam Pudlac; Manuela Vaneckova; Dana Horakova; Jan Krasensky; Zsoka Varga; Lukas Lambert Journal: Quant Imaging Med Surg Date: 2021-09
Authors: Adam Pudlac; Andrea Burgetova; Petr Dusek; Petra Nytrova; Manuela Vaneckova; Dana Horakova; Jan Krasensky; Lukas Lambert Journal: Biomed Res Int Date: 2020-05-19 Impact factor: 3.411
Authors: Ferdinand Schweser; Jesper Hagemeier; Michael G Dwyer; Niels Bergsland; Simon Hametner; Bianca Weinstock-Guttman; Robert Zivadinov Journal: Hum Brain Mapp Date: 2020-12-30 Impact factor: 5.038
Authors: Andrea Burgetova; Petr Dusek; Tomas Uher; Manuela Vaneckova; Martin Vejrazka; Romana Burgetova; Dana Horakova; Barbora Srpova; Jan Krasensky; Lukas Lambert Journal: Diagnostics (Basel) Date: 2022-06-01