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Literature DB >> 2478460

An epitope on C4 beta light (L) chains detected by human anti-Rg; its relationship with beta chain polymorphism and MHC associations.

Abstract

Two out of ten Rg-specific antisera tested contain a third antibody specific for the beta chain of C4. Analysis of the beta chains of 66 unrelated individuals by sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed that the epitope detected is located exclusively on the light (L) beta chain. A strong, but incomplete, association between the beta chain epitope and the expression of the Rg:2 determinant on the alpha chain of the same protein was also observed. While H (heavy) and L beta chains were not associated with a particular C4 isotype, previously unrecorded associations of beta chain polymorphism with the DR locus have been established.

Entities: Chemical Gene Species

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Year: 1989 PMID： 2478460 DOI： 10.1007/bf02425274

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

32 in total

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Authors: C M Giles
Journal: Vox Sang Date: 1985 Impact factor: 2.144

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Journal: Hum Immunol Date: 1984-10 Impact factor: 2.850

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Journal: Proc Natl Acad Sci U S A Date: 1981-09 Impact factor: 11.205

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Authors: C M Giles; J R Batchelor; I A Dodi; A H Fielder; C Rittner; G Mauff; K Bender; C Levene; G M Schreuder; L J Wells
Journal: J Immunogenet Date: 1984 Oct-Dec

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Journal: Hum Genet Date: 1983 Impact factor: 4.132

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Journal: Proc Natl Acad Sci U S A Date: 1985-01 Impact factor: 11.205

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Journal: Nature Date: 1982-08-26 Impact factor: 49.962

9. An estimate on the frequency of duplicated haplotypes and silent alleles of human C4 protein polymorphism. I. Investigations in healthy Caucasoid families.

Authors: M Steuer; G Mauff; C Adam; M P Baur; K Bender; J Goetz; S F Goldmann; G Hauptmann; M Neugebauer; M M Tongio
Journal: Tissue Antigens Date: 1989-05

3. Great genotypic and phenotypic diversities associated with copy-number variations of complement C4 and RP-C4-CYP21-TNX (RCCX) modules: a comparison of Asian-Indian and European American populations.

Authors: Kapil Saxena; Kathryn J Kitzmiller; Yee Ling Wu; Bi Zhou; Nazreen Esack; Leena Hiremath; Erwin K Chung; Yan Yang; C Yung Yu
Journal: Mol Immunol Date: 2009-01-09 Impact factor: 4.407

3 in total