Literature DB >> 6885058

The C4 beta-chain: evidence for a genetically determined polymorphism.

G Mauff, M Steuer, M Weck, K Bender.   

Abstract

Using sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) five different beta-chain patterns of denaturated human C4 were observed: C4 beta H, beta H greater than L, beta H = L, beta H less than L, and beta L. In 32 families with 174 offspring the segregation of C4 beta-chain types followed that of the other major histocompatibility complex (MHC) markers. It is concluded that the C4 beta-chain patterns represent a genetically determined polymorphism, coded within the known C4A and B gene region.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6885058     DOI： 10.1007/bf00327123

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  9 in total

1.  Cell-free synthesis of the fourth component of guinea pig complement (C4): identification of a precursor of serum C4 (pro-C4).

Authors:  R E Hall; H R Colten
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

2.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

3.  Two HLA-linked loci controlling the fourth component of human complement.

Authors:  G J O'Neill; S Y Yang; B Dupont
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

4.  Localisation of Chido and Rodgers determinants to the C4d fragment of human C4.

Authors:  C A Tilley; D G Romans; M C Crookston
Journal:  Nature       Date:  1978-12-14       Impact factor: 49.962

5.  Molecular characterization of the Ss and Slp (C4) proteins of the mouse H-2 complex: subunit composition, chain size polymorphism, and an intracellular (PRO-Ss) precursor.

Authors:  M H Roos; J P Atkinson; D C Shreffler
Journal:  J Immunol       Date:  1978-09       Impact factor: 5.422

6.  Statement on the nomenclature of human C4 allotypes.

Authors:  G Mauff; C A Alper; Z Awdeh; J R Batchelor; J Bertrams; G Bruun-Petersen; R L Dawkins; P Démant; J Edwards; H Grosse-Wilde; G Hauptmann; P Klouda; L Lamm; E Mollenhauer; C Nerl; B Olaisen; G O'Neill; C Rittner; M H Roos; V Skanes; P Teisberg; L Wells
Journal:  Immunobiology       Date:  1983-03       Impact factor: 3.144

7.  Electrophoretic polymorphism of human C4 is due to charge differences in the alpha chain, presumably in the C4d fragment.

Authors:  B Mevåg; B Olaisen; P Teisberg
Journal:  Scand J Immunol       Date:  1981-09       Impact factor: 3.487

8.  A molecular basis for the two locus model of human complement component C4.

Authors:  M H Roos; E Mollenhauer; P Démant; C Rittner
Journal:  Nature       Date:  1982-08-26       Impact factor: 49.962

9.  Inherited structural polymorphism of the fourth component of human complement.

Authors:  Z L Awdeh; C A Alper
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205
  9 in total
  12 in total

1.  An epitope on C4 beta light (L) chains detected by human anti-Rg; its relationship with beta chain polymorphism and MHC associations.

Authors:  T Robson; R N Heard; C M Giles
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

2.  Structure and polymorphism of the feline complement component C4.

Authors:  A I de Kroon; G Doxiadis; I Doxiadis; E J Hensen
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

3.  C3 and Bf complement types in chronic renal failure.

Authors:  S S Papiha; R S Rodger
Journal:  Hum Genet       Date:  1986-03       Impact factor: 4.132

4.  Haplotype study on C4 polymorphism in Japanese. Associations with MHC alleles, complotypes, and HLA-complement haplotypes.

Authors:  K Tokunaga; K Omoto; T Akaza; N Akiyama; H Amemiya; S Naito; T Sasazuki; H Satoh; T Juji
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

5.  The study of a French family with two duplicated C4A haplotypes.

Authors:  C M Giles; B Uring-Lambert; W Boksch; M Braun; J Goetz; R Neumann; G Mauff; G Hauptmann
Journal:  Hum Genet       Date:  1987-12       Impact factor: 4.132

6.  Genetics of human C4 polymorphism: detection and segregation of rare and duplicated haplotypes.

Authors:  C Rittner; C M Giles; M H Roos; P Démant; E Mollenhauer
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

7.  Human C4 polymorphism: pedigree analysis of qualitative, quantitative, and functional parameters as a basis for phenotype interpretations.

Authors:  G Mauff; K Bender; C M Giles; S Goldmann; W Opferkuch; B Wachauf
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

8.  MHC-linked class III genes. Analysis of C4 gene frequencies, complotypes and associations with distinct HLA haplotypes in German Caucasians.

Authors:  D J Schendel; G J O'Neill; R Wank
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

9.  The molecular structure of different polymorphic forms of canine C3 and C4.

Authors:  P H Kay; R L Dawkins; J W Penhale
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

10.  C4 polymorphism in the dog: molecular heterogeneity of the C4 alpha and C4 gamma subunit chains.

Authors:  G J O'Neill; M Lang; C Nerl; H J Deeg
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.