Literature DB >> 24780272

A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor.

Jevgenij A Raskatov1, James W Puckett1, Peter B Dervan2.   

Abstract

In an effort to quantitate Py-Im polyamide concentrations in vivo, we synthesized the C-14 radioactively labeled compounds 1-3, and investigated their tumor localization in a subcutaneous xenograft model of prostate cancer (LNCaP). Tumor concentrations were compared with representative host tissues, and exhibited a certain degree of preferential localization to the xenograft. Compound accumulation upon repeated administration was measured. Py-Im polyamide 1 was found to accumulate in LNCaP tumors at concentrations similar to the IC50 value for this compound in cell culture experiments.
Copyright © 2014. Published by Elsevier Ltd.

Entities:  

Keywords:  Accumulation; C-14 radiolabeling; Chemotherapy; DNA binding; Small molecule

Mesh：

Substances：

Year:  2014        PMID： 24780272      PMCID： PMC4134956          DOI： 10.1016/j.bmc.2014.04.010

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


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